@article { , title = {Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis.}, abstract = {Context: The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations. Objective: The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations. Data Sources: Three databases were searched electronically. In addition, reference lists of relevant articles were screened. Study Selection: A total of 16 studies, comprising 2587 participants and 75 correlation coefficients were selected for inclusion in the review. Data Extraction: Data were extracted from each study using a standardized form. Results: Multilevel modeling indicated opposing relationships between BMD and adiposity: absolute adiposity correlated positively, and relative adiposity negatively, with BMD. Sex and age were the primary moderators of these relationships. Strong evidence supported a negative relationship between relative adipose mass and BMD in men (R=-0.37; 95\%CI, -0.57 to -0.12) and in those aged less than 25 years (R=-0.28; 95\%CI, -0.45 to -0.08). Conclusion: To prevent bone loss in overweight and obese populations, nutrition- and exercise-based interventions that focus on a controlled reduction of adipose mass with concomitant preservation of lean mass are recommended. Systematic Review Registration: PROSPERO no. CRD42015024313. Please note that the title given on this manuscript Does adipose tissue mass positively or negatively influence bone mass in an overweight or obese population? A systematic review and meta-analysis. differs from the published version.}, doi = {10.1093/nutrit/nux046}, eissn = {1753-4887}, issn = {0029-6643}, issue = {10}, journal = {Nutrition reviews}, note = {COMPLETED -- Rec'd doc 17/11/2017 LM -- Chased AAM 16/11/2017 LM -- Doc requested 27/10/2017 LM -- Info via WoS alert 27/10/2017 LM ADDITIONAL INFORMATION: Swinton, Paul -- Panel A}, pages = {858-870}, publicationstatus = {Published}, publisher = {Oxford University Press}, url = {http://hdl.handle.net/10059/2596}, volume = {75}, keyword = {Health & Wellbeing, Adiposity, Body composition, Bone mass, Chronic condition, Obesity, Osteoporosis, Nutrition}, year = {2017}, author = {Dolan, Eimear and Swinton, Paul A. and Sale, Craig and Healy, Aoife and O'Reilly, John} }