@article { , title = {Glassy carbon electrode modified with 7,7,8,8-tetracyanoquinodimethane and graphene oxide triggered a synergistic effect: low-potential amperometric detection of reduced glutathione.}, abstract = {A sensitive electrochemical sensor based on the synergistic effect of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and graphene oxide (GO) for low-potential amperometric detection of reduced glutathione (GSH) in pH 7.2 phosphate buffer solution (PBS) has been reported. This is the first time that the combination of GO and TCNQ have been successfully employed to construct an electrochemical sensor for the detection of glutathione. The surface of the glassy carbon electrode (GCE) was modified by a drop casting using TCNQ and GO. Cyclic voltammetric measurements showed that TCNQ and GO triggered a synergistic effect and exhibited an unexpected electrocatalytic activity towards GSH oxidation, compared to GCE modified with only GO, TCNQ or TCNQ/electrochemically reduced GO. Three oxidation waves for GSH were found at −0.05, 0.1 and 0.5 V, respectively. Amperometric techniques were employed to detect GSH sensitively using a GCE modified with TCNQ/GO at −0.05 V. The electrochemical sensor showed a wide linear range from 0.25 to 124.3 μM and 124.3 μM to 1.67 mM with a limit of detection of 0.15 μM. The electroanalytical sensor was successfully applied towards the detection of GSH in an eye drop solution.}, doi = {10.1016/j.bios.2017.04.026}, eissn = {1873-4235}, issn = {0956-5663}, journal = {Biosensors and bioelectronics}, note = {COMPLETED -- Rec'd AAM 20/2/2018 LM -- Unable to obtain AAM 2/2/2018 LM -- Chased AAM 16/1/2018, 4/1/2018, 7/12/2017, 16/11/2017 LM -- Rec'd VOR from contact, will reply to ask if we can chase lead author for AAM 2/11/2017 LM -- Chased docs 16/10/2017 LM -- GB been in contact with CF (see email 20/9/2017), CF will try to get items to us 21/9/2017 LM -- Contact to be away from uni until Aug 2017 18/7/2017 LM -- Chased again 19/6/2017 LM -- Chased doc 5/6/2017 LM -- Info via SD alert 27/4/2017, requested doc from contact 8/5/2017 LM ADDITIONAL INFORMATION: Fernandez, Carlos -- Panel A}, pages = {1-7}, publicationstatus = {Published}, publisher = {Elsevier}, url = {http://hdl.handle.net/10059/2777}, volume = {96}, keyword = {Electrochemical sensor, 7,7,8,8-tetracyanoquinodimethane (TCNQ), Graphene oxide, Reduced glutathione}, year = {2017}, author = {Yuan, Baiqing and Xu, Chunying and Zhang, Renchun and Lv, Donghui and Li, Sujuan and Zhang, Daojun and Liu, Lin and Fernandez, Carlos} }