@article { , title = {Multi-objective evolutionary design of antibiotic treatments.}, abstract = {Antibiotic resistance is one of the major challenges we face in modern times. Antibiotic use, especially their overuse, is the single most important driver of antibiotic resistance. Efforts have been made to reduce unnecessary drug prescriptions, but limited work is devoted to optimising dosage regimes when they are prescribed. The design of antibiotic treatments can be formulated as an optimisation problem where candidate solutions are encoded as vectors of dosages per day. The formulation naturally gives rise to competing objectives, as we want to maximise the treatment effectiveness while minimising the total drug use, the treatment duration and the concentration of antibiotic experienced by the patient. This article combines a recent mathematical model of bacterial growth including both susceptible and resistant bacteria, with a multi-objective evolutionary algorithm in order to automatically design successful antibiotic treatments. We consider alternative formulations combining relevant objectives and constraints. Our approach obtains shorter treatments, with improved success rates and smaller amounts of drug than the standard practice of administering daily fixed doses. These new treatments consistently involve a higher initial dose followed by lower tapered doses.}, doi = {10.1016/j.artmed.2019.101759}, eissn = {1873-2860}, issn = {0933-3657}, journal = {Artificial intelligence in medicine}, note = {INFO COMPLETE (Final details available 17.12.2019 GB -- Info via SD alert 22/11/2019 LM) PERMISSION GRANTED (version = AAM; embargo = 12 months; licence = BY-NC-ND; SHERPA = http://sherpa.ac.uk/romeo/issn/0933-3657/ ) DOCUMENT READY (Pre proof downloaded 22/11/2019 LM) ADDITIONAL INFORMATION (Contact - Christie, Lee -- Licence requirements not compliant with funder requirements 28/11/2019 LM)}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://rgu-repository.worktribe.com/output/784417}, volume = {102}, keyword = {Computational Intelligence (CI), Antibiotic resistance, Antimicrobial resistance, AMR, Evolutionary computation, Stochastic model}, year = {2020}, author = {Ochoa, Gabriela and Christie, Lee A. and Brownlee, Alexander E. and Hoyle, Andrew} }