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Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. (2014)
Journal Article
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2014. Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. Oncology letters [online], 8(1), pages 374-378. Available from: https://doi.org/10.3892/ol.2014.2085

Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher in obese postmenopausal women... Read More about Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling..

Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. (2008)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. Presented at 6th annual World congress on insulin resistance syndrome 2008 (WCIRS 2008), 25-27 September 2008, Los Angeles, U.S.A.

Recent findings suggest a connection between obesity and breast cancer. Obesity is linked with higher incidences of insulin resistance as part of the metabolic syndrome, resulting in chronically elevated insulin plasma levels. We examined the effect... Read More about Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways..

Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. (2008)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. Presented at 16th European congress on obesity 2008 (ECO 2008), 14-17 May 2008, Geneva, Switzerland.

A growing number of clinical studies validate a relation of insulin resistance and breast cancer in obese patients. We hypothesised that high plasma insulin levels cause aberrant insulin signalling in breast epithelial cells which may be responsible... Read More about Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity..