Outputs (18)

Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. (2021)
Thesis
BRUNET, M. 2021. Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. Robert Gordon University, MRes thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1446968

Colorectal cancer is one of the most severe causes of mortality worldwide accounting for 10% of total cancer cases. Although recent advances in early diagnosis have reduced the mortality rate associated with CRC, patients suffering from the later met... Read More about Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines..

Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. (2020)
Journal Article
POHL, F., GOUA, M., YATES, K., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2021. Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. Journal of food biochemistry [online], 45(2), article e13592. Available from: https://doi.org/10.1111/jfbc.13592

With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study. For the first time, we highlight the neuroprotective proper... Read More about Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells..

Germination improves the polyphenolic profile and functional value of mung bean (Vigna radiata L.). (2020)
Journal Article
KAPRAVELOU, G., MARTINEZ, R., PERAZZOLI, G., GONZÁLEZ, C.S., LLOPIS, J., CANTARERO, S., GOUA, M., BERMANO, G., PRADOS, J., MELGUIZO, C., ARANDA, P., LÓPEZ-JURADO, M. and PORRES, J.M. 2020. Germination improves the polyphenolic profile and functional value of mung bean (Vigna radiata L.). Antioxidants [online], 9(8), article ID 746. Available from: https://doi.org/10.3390/antiox9080746

The use of legumes as functional foods has gained increasing attention for the prevention and treatment of the so called non-communicable diseases that are highly prevalent worldwide. In this regard, biotechnological approaches for the enhancement of... Read More about Germination improves the polyphenolic profile and functional value of mung bean (Vigna radiata L.)..

GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. (2019)
Journal Article
POHL, F., TEIXEIRA-CASTRO, A., COSTA, M.D., LINDSAY, V., FIÚZA-FERNANDES, J., GOUA, M., BERMANO, G., RUSSELL, W., MACIEL, P. and KONG THOO LIN, P. 2019. GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. Frontiers in neuroscience [online], 13, article ID 1091. Available from: https://doi.org/10.3389/fnins.2019.01091

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson’s disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as impor... Read More about GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation..

The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. (2019)
Thesis
POHL, F. 2019. The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Rapeseed pomace (RSP) is the waste/by-product obtained after edible oil production from Brassica napus and is currently used as animal feed. In an attempt to revalorize this by-product as a potential nutraceutical for the treatment or prevention of n... Read More about The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases..

Cyanopeptolins with trypsin and chymotrypsin inhibitory activity from the cyanobacterium nostoc edaphicum CCNP1411. (2018)
Journal Article
MAZUR-MARZEC, H., FIDOR, A., CEGLOWSKA, M., WIECZERZAK, E., KROPIDLOWSKA, M., GOUA, M., MACASKILL, J. and EDWARDS, C. 2018. Cyanopeptolins with trypsin and chymotrypsin inhibitory activity from the cyanobacterium nostoc edaphicum CCNP1411. Marine drugs [online], 16(7), article number 220. Available from: https://doi.org/10.3390/md16070220

Cyanopeptolins (CPs) are one of the most frequently occurring cyanobacterial peptides, many of which are inhibitors of serine proteases. Some CP variants are also acutely toxic to aquatic organisms, especially small crustaceans. In this study, thirte... Read More about Cyanopeptolins with trypsin and chymotrypsin inhibitory activity from the cyanobacterium nostoc edaphicum CCNP1411..

Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies. (2018)
Thesis
KOPSIDA, M. 2018. Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies. Robert Gordon University, PhD thesis.

Breast cancer is the most commonly occurring cancer in women, with incidence rates approaching 1.38 million cases per year worldwide. Over the last few decades, there have been numerous attempts to develop, synthesise and advance into the clinic nove... Read More about Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies..

Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. (2017)
Journal Article
BARRON, G.A., GOUA, M., WAHLE, K.W.J. and BERMANO, G. 2017. Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. Oncology reports [online], 38(3), pages 1886-1894. Available from: https://doi.org/10.3892/or.2017.5803

The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matche... Read More about Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation..

Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. (2017)
Journal Article
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., SCOBBIE, L., MACIEL, P. and KONG THOO LIN, P. 2018. Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. Food chemistry [online], 239, pages 323-332. Available from: https://doi.org/10.1016/j.foodchem.2017.06.129

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. Analysis of ubiquitous secondary metabolites in RSP samples (two breeds, harvested in 2012/2014 respectively from North East of Scotland) and their eth... Read More about Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties..

Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. (2016)
Journal Article
KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], 14(41), pages 9780-9789. Available from: https://doi.org/10.1039/C6OB01850E

Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and cytotoxic activities. By modifyi... Read More about Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells..