Outputs (56)

Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. (2024)
Journal Article
MAHADIK, N., BARRON, G.A., KONG THOO LIN, P. and THOMPSON, C.J. [2024]. Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. RSC pharmaceutics [online], Advance Articles. Available from: https://doi.org/10.1039/D3PM00075C

Alzheimer's disease (AD) is a progressive, neurodegenerative condition. There are clear markers for the presence and progression of the disease, including β-amyloid (Aβ) plaques and Tau tangles, with many potential causes debated in the scientific co... Read More about Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease..

Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. (2024)
Journal Article
POHL, F., LINDSAY-MCGEE, V., KONG THOO LIN, P., MACIEL, P. and TEIXEIRA-CASTRO, A. 2024. Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. microPublication biology [online], 2024(2), 001086. Available from: https://doi.org/10.17912/micropub.biology.001086

Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer's disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar At... Read More about Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model..

UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. (2023)
Journal Article
POHL, F., GERMANN, A.L., MAO, J., HOU, S., BAKARE, B., KONG THOO LIN, P., YATES, K., NONET, M.L., AKK, G., KORNFELD, K. and HELD, J.M. 2023. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. Science advances [online], 9(44). Available from: https://doi.org/10.1126/sciadv.adh2584

The γ-aminobutyric acid–mediated (GABAergic) system participates in many aspects of organismal physiology and disease, including proteostasis, neuronal dysfunction and life-span extension. Many of these phenotypes are also regulated by reactive oxyge... Read More about UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously..

Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. (2023)
Journal Article
BLAIKIE, L., WELGAMAGE DON, A., FRANZEN, X., FERNANDEZ, C., FAISAL, N. and KONG THOO LIN, P. [2023]. Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. Waste and biomass valorization [online], Online First. Available from: https://doi.org/10.1007/s12649-023-02292-4

Waste by-products such as pot ale are abundantly produced during the whisky distillation process and are conventionally used as livestock feed, however a significant proportion continues to require land and sea disposal. Here, the novel potential of... Read More about Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential..

Experimental modelling of Alzheimer’s disease for therapeutic screening. (2022)
Journal Article
BLAIKIE, L., KAY, G., MACIEL, P. and KONG THOO LIN, P. 2022. Experimental modelling of Alzheimer’s disease for therapeutic screening. European journal of medicinal chemistry reports [online], 5, article 100044. Available from: https://doi.org/10.1016/j.ejmcr.2022.100044

Neurodegenerative diseases, including Alzheimer’s disease (AD), pose a significant and urgent challenge to healthcare systems worldwide. With an increasing life expectancy, these progressive age-related disorders are expected to rise exponentially. N... Read More about Experimental modelling of Alzheimer’s disease for therapeutic screening..

DNA profiling of single sperm cells after whole genome amplification. (2021)
Journal Article
THEUNISSEN, G.M.G., GIBB, A., KONG THOO LIN, P., ROLF, B., FORAT, S. and JÄGER, R. 2021. DNA profiling of single sperm cells after whole genome amplification. Forensic science international: reports [online], 4, article 100240. Available from: https://doi.org/10.1016/j.fsir.2021.100240

Intimate swabs taken for examination in sexual assault cases typically yield mixtures of sperm and epithelial cell types. While powerful, differential extraction protocols to overcome such cell type mixtures by separate lysis of epithelial cells and... Read More about DNA profiling of single sperm cells after whole genome amplification..

Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. (2021)
Thesis
BRUNET, M. 2021. Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. Robert Gordon University, MRes thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1446968

Colorectal cancer is one of the most severe causes of mortality worldwide accounting for 10% of total cancer cases. Although recent advances in early diagnosis have reduced the mortality rate associated with CRC, patients suffering from the later met... Read More about Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines..

Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. (2020)
Journal Article
POHL, F., GOUA, M., YATES, K., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2021. Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. Journal of food biochemistry [online], 45(2), article e13592. Available from: https://doi.org/10.1111/jfbc.13592

With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study. For the first time, we highlight the neuroprotective proper... Read More about Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells..

Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease. (2020)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2020. Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer's disease. Bioorganic and medical chemistry letters [online], 30(21), article ID 127505. Available from: https://doi.org/10.1016/j.bmcl.2020.127505

A number of novel naphthalimido and phthalimido vanillin derivatives were synthesised, and evaluated as antioxidants and cholinesterase inhibitors in vitro. Antioxidant activity was assessed using DPPH, FRAP, and ORAC assays. All compounds demonstrat... Read More about Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease..

Electrochemical determination of gallic acid in food matrices using novel materials. (2020)
Thesis
CHIKERE, C.O. 2020. Electrochemical determination of gallic acid in food matrices using novel materials. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Gallic acid (GA), as an endogenous polyphenol, has shown many different important properties that have influenced its use in the food and pharmaceutical industry. These properties include its antioxidant, anti-cancer, anti-tumor, anti-HIV and anti-ul... Read More about Electrochemical determination of gallic acid in food matrices using novel materials..