Outputs (104)

Studies on the role of GPR55 in cardiovascular physiology and pathophysiology. (2017)
Thesis
ROBERTSON-GRAY, O.J. 2017. Studies on the role of GPR55 in cardiovascular physiology and pathophysiology. Robert Gordon University, PhD thesis.

Atherosclerosis is a multifactorial, chronic inflammatory condition characterised by endothelial dysfunction, hyperlipidaemia and the accumulation of fatty deposits within the tunica intima of medium-to-large sized muscular arteries. This disease can... Read More about Studies on the role of GPR55 in cardiovascular physiology and pathophysiology..

Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. (2017)
Journal Article
TURNER, A.D., WAACK, J., LEWIS, A., EDWARDS, C. and LAWTON, L. 2018. Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. Journal of chromatography B [online], 1074-1075, pages 111-123. Available from: https://doi.org/10.1016/j.jchromb.2017.12.032

A simple, rapid UHPLC-MS/MS method has been developed and optimised for the quantitation of microcystins and nodularin in wide variety of sample matrices. Microcystin analogues targeted were MC-LR, MC-RR, MC-LA, MC-LY, MC-LF, LC-LW, MC-YR, MC-WR, [As... Read More about Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders..

Pregnancy, prescription medicines and the potential risk of herb-drug interactions: a cross-sectional survey. (2017)
Journal Article
MCLAY, J.S., IZZATI, N., PALLIVALAPILA, A.R., SHETTY, A., PANDE, B., RORE, C., AL HAIL, M. and STEWART, D. 2017. Pregnancy, prescription medicines and the potential risk of herb-drug interactions: a cross-sectional survey. BMC complementary and alternative medicine [online], 17, article ID 543. Available from: https://doi.org/10.1186/s12906-017-2052-1

Background: - Pregnant women are routinely prescribed medicines while self-medicating with herbal natural products to treat predominantly pregnancy related conditions. The aim of this study was to assess the potential for herb-drug interactions (HDIs... Read More about Pregnancy, prescription medicines and the potential risk of herb-drug interactions: a cross-sectional survey..

Supporting shared decision-making and people's understanding of medicines: an exploration of the acceptability and comprehensibility of patient information. (2017)
Journal Article
GIBSON SMITH, K., BOOTH, J.L., STEWART, D., PFLEGER, S., MCIVER, L. and MACLURE, K. 2017. Supporting shared decision-making and people's understanding of medicines: an exploration of the acceptability and comprehensibility of patient information. Pharmacy practice [online], 15(4), article number 1082. Available from: https://doi.org/10.18549/PharmPract.2017.04.1082

Patient information may assist in promoting shared decision-making, however it is imperative that the information presented is comprehensible and acceptable to the target audience. This study sought to explore the acceptability and comprehensibility... Read More about Supporting shared decision-making and people's understanding of medicines: an exploration of the acceptability and comprehensibility of patient information..

Zinc-modified nanotransporter of doxorubicin for targeted prostate cancer delivery. (2017)
Journal Article
SKALICKOVA, S., LOFFELMANN, M., GARGULAK, M., KEPINSKA, M., DOCEKALOVA, M., UHLIROVA, D., STANKOVA, M., FERNANDEZ, C., MILNEROWICZ, H., RUTTKAY-NEDECKY, B. and KIZEK, R. 2017. Zinc-modified nanotransporter of doxorubicin for targeted prostate cancer delivery. Nanomaterials [online], 7(12), article ID 435. Available from: https://doi.org/10.3390/nano7120435

This work investigated the preparation of chitosan nanoparticles used as carriers for doxorubicin for targeted cancer delivery. Prepared nanocarriers were stabilized and functionalized via zinc ions incorporated into the chitosan nanoparticle backbon... Read More about Zinc-modified nanotransporter of doxorubicin for targeted prostate cancer delivery..

Changes in diet following a cancer diagnosis in Scotland. (2017)
Presentation / Conference
MASSON, L.F., VERRA, D., CUMMING, H., CAMERON, H. and ROBINSON, E. 2017. Changes in diet following a cancer diagnosis in Scotland. Presented at the 2017 Nutrition Society winter meeting: diet, nutrition and the changing face of cancer survivorship, 5-6 December 2017, London, UK.

Cancer survival has improved in Scotland from an age-standardised relative survival at five years of 39.6 % in 1987–1991 to 59.3 % in 2007–2011 in men and women aged 15–74 years. However, long-term cancer survival is associated with increased inciden... Read More about Changes in diet following a cancer diagnosis in Scotland..

Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties. (2017)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I. and KONG THOO LIN, P. 2017. Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties. European journal of medicinal chemistry [online], 143, pages 745-754. Available from: https://doi.org/10.1016/j.ejmech.2017.11.072

Antioxidants have been the subject of intense research interest mainly due to their beneficial properties associated with human health and wellbeing. Phenolic molecules, such as naturally occurring Resveratrol and Vanillin, are well known for their a... Read More about Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties..

Application of camelid heavy-chain variable domains (VHHs) in prevention and treatment of bacterial and viral infections. (2017)
Journal Article
WILKEN, L. and MCPHERSON, A. 2018. Application of camelid heavy-chain variable domains (VHHs) in prevention and treatment of bacterial and viral infections. International reviews of immunology [online], 37(1), pages 69-76. Available from: https://doi.org/10.1080/08830185.2017.1397657

Camelid heavy-chain variable domains (VHHs) are the smallest, intact, antigen-binding units to occur in nature. VHHs possess high degrees of solubility and robustness enabling generation of multivalent constructs with increased avidity - characterist... Read More about Application of camelid heavy-chain variable domains (VHHs) in prevention and treatment of bacterial and viral infections..

Unprecedented homotopy perturbation method for solving nonlinear equations in the enzymatic reaction of glucose in a spherical matrix. (2017)
Journal Article
SARANYA, K., MOHAN, V., KIZEK, R., FERNANDEZ, C. and RAJENDRAN, L. 2018. Unprecedented homotopy perturbation method for solving nonlinear equations in the enzymatic reaction of glucose in a spherical matrix. Bioprocess and biosystems engineering [online], 41(2), pages 281-294. Available from: https://doi.org/10.1007/s00449-017-1865-0

The theory of glucose-responsive composite membranes for the planar diffusion and reaction process is extended to a microsphere membrane. The theoretical model of glucose oxidation and hydrogen peroxide production in the chitosan-aliginate microspher... Read More about Unprecedented homotopy perturbation method for solving nonlinear equations in the enzymatic reaction of glucose in a spherical matrix..

A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. (2017)
Journal Article
STEWART, D., GIBSON-SMITH, K., MACLURE, K., MAIR, A., ALONSO, A., CODINA, C., CITTADINI, A., FERNANDEZ-LLIMOS, F., FLEMING, G., GENNIMATA, D., GILLESPIE, U., HARRISON, C., JUNIUS-WALKER, U., KARDAS, P., KEMPEN, T., KINNEAR, M., LEWEK, P., MALVA, J., MCINTOSH, J., SCULLIN, C. and WIESE, B. 2017. A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. PLOS one [online], 12(11), e0188348. Available from: https://doi.org/10.1371/journal.pone.0188348

Background:- Inappropriate use of multiple medicines (inappropriate polypharmacy) is a major challenge in older people with consequences of increased prevalence and severity of adverse drug reactions and interactions, and reduced medicines adherence.... Read More about A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people..