Anti-cancer drug interaction with cytochrome P450 CYP1B1.

McFadyen, Morag C.E.; Melvin, William T.; Murray, Graeme I.

Abstract

One mechanism potentially amenable to chemotherapeutic intervention involves cytochrome P450 CYP1B1. Our research has established the concept of over-expression of individual forms of cytochrome P450 - in particular CYP1B1 - in a range of solid tumours. This presentation shares the results of a study in which we used expressed human CYP1B1 in a competitive microassay, involving the deethylation of ethoxyresorufin to resorufin, to extend our screen of anti-cancer drugs and identify which ones interact with CYP1B1 by assessing the change in resorufin production over time.

Citation

MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. Presented at the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK.

• Presentation Conference Type: Lecture
• Conference Name: 2003 British cancer research meeting (BCRM 2003)
• Conference Location: Bournemouth, UK
• Start Date: Jul 2, 2003
• End Date: Jul 5, 2003
• Deposit Date: Mar 14, 2023
• Publicly Available Date: Mar 14, 2023
• Keywords: Cytochrome P450; Chemotherapy; Tumour cells
• Public URL: https://rgu-repository.worktribe.com/output/1912221
• Additional Information: The extended abstract for this presentation has been published with the following citation: MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. British journal of cancer [online], 88(Suppl 1): abstracts from the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK, page S16, abstract number 3.8. Available from: https://doi.org/10.1038/sj.bjc.6601055