Morag C.E. McFadyen
Anti-cancer drug interaction with cytochrome P450 CYP1B1.
McFadyen, Morag C.E.; Melvin, William T.; Murray, Graeme I.
Authors
William T. Melvin
Graeme I. Murray
Abstract
One mechanism potentially amenable to chemotherapeutic intervention involves cytochrome P450 CYP1B1. Our research has established the concept of over-expression of individual forms of cytochrome P450 - in particular CYP1B1 - in a range of solid tumours. This presentation shares the results of a study in which we used expressed human CYP1B1 in a competitive microassay, involving the deethylation of ethoxyresorufin to resorufin, to extend our screen of anti-cancer drugs and identify which ones interact with CYP1B1 by assessing the change in resorufin production over time.
Citation
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. Presented at the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK.
Presentation Conference Type | Presentation / Talk |
---|---|
Conference Name | 2003 British cancer research meeting (BCRM 2003) |
Start Date | Jul 2, 2003 |
End Date | Jul 5, 2003 |
Deposit Date | Mar 14, 2023 |
Publicly Available Date | Mar 14, 2023 |
Peer Reviewed | Peer Reviewed |
Keywords | Cytochrome P450; Chemotherapy; Tumour cells |
Public URL | https://rgu-repository.worktribe.com/output/1912221 |
Additional Information | The extended abstract for this presentation has been published with the following citation: MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. British journal of cancer [online], 88(Suppl 1): abstracts from the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK, page S16, abstract number 3.8. Available from: https://doi.org/10.1038/sj.bjc.6601055 |
Files
MCFADYEN 2003 Anti-cancer drug interaction (EXTENDED ABSTRACT)
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-sa/3.0/
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