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The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials.

Pohl, Franziska; Lin, Paul Kong Thoo

Authors

Franziska Pohl

Paul Kong Thoo Lin



Abstract

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Huntington's disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase over the next decades due to increasing life expectancies. No cure is currently available for the treatment of these conditions; only drugs, which merely alleviate the symptoms. Oxidative stress has long been associated with neurodegeneration, whether as a cause or as part of the downstream results caused by other factors. Thus, the use of antioxidants to counter cellular oxidative stress within the nervous system has been suggested as a potential treatment option for neurological disorders. Over the last decade, significant research has focused on the potential use of natural antioxidants to target oxidative stress. However, clinical trial results have lacked success for the treatment of patients with neurological disorders. The knowledge that natural extracts show other positive molecular activities in addition to antioxidant activity, however, has led to further research of natural extracts for their potential use as prevention or treatment/management of neurodegenerative diseases. This review will cover several in vitro and in vivo research studies, as well as clinical trials, and highlight the potential of natural antioxidants.

Journal Article Type Article
Publication Date Dec 31, 2018
Journal Molecules
Electronic ISSN 1420-3049
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 23
Issue 12
Article Number 3283
Institution Citation POHL, F. and KONG THOO LIN, P. 2018. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. Molecules [online], 23(12), article ID 3283. Available from: https://doi.org/10.3390/molecules23123283
DOI https://doi.org/10.3390/molecules23123283
Keywords Antioxidants; Natural products; In vitro; In vivo; Clinical trials; Plant extracts; Phytochemicals; Phenolics; Ginkgo biloba; Secondary metabolites

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