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Exploiting the antiparasitic activity of naphthalimides derivatives.


Gabriela Cristo


Jennifer Noro

Catarina Baptista


Anabela Cordeiro-Da-Silva


A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmania infantum, Trypanosomabrucei and Trypanosoma cruzi. Additionally, toxicity was determined by growth inhibition of THP-1 derived macrophages. The results suggest that chemical modifications in the carbon chain linking the naphthalimide and the substituting groups have different effects in the parasites. This work should provide new insights for the design and optimization of more potent and directed naphthalimide derivatives against these organisms.


CRISTO, G., GASPAR, L., NORO, J., BAPTISTA, C., KONG THOO LIN, P., ALVES, M.J. and CORDEIRO-DA-SILVA, A. 2016. Exploiting the antiparasitic activity of naphthalimides derivatives. International journal of chemistry and pharmaceutical sciences [online], 4(1), pages 19-23. Available from:

Journal Article Type Article
Acceptance Date Dec 26, 2015
Online Publication Date Jan 27, 2016
Publication Date Jan 31, 2016
Deposit Date Mar 23, 2020
Publicly Available Date May 8, 2020
Journal International Journal of Chemistry and Pharmaceutical Sciences
Print ISSN 2321-3132
Publisher Pharma Research Library
Peer Reviewed Peer Reviewed
Volume 4
Issue 1
Pages 19-23
Keywords Leishmania infantum; Trypanosoma brucei; Trypanosoma cruzi
Public URL
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