All Outputs (4)

Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype. (2020)
Journal Article
MORROW, G.B., BEAVIS, J., HARPER, S., BIGNELL, P., LAFFAN, M.A. and CURRY, N. 2021. Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype. Thrombosis research [online], 197, pages 100-108. Available from: https://doi.org/10.1016/j.thromres.2020.11.002

A novel variant in the thrombomodulin (TM) gene, c.1487delC,p.(Pro496Argfs*10), referred to as Pro496Argfs*10, was identified in a family with an unexplained bleeding disorder. The Pro496Argfs*10 variant results in loss of the transmembrane and intra... Read More about Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype..

Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. (2020)
Journal Article
WHYTE, C.S., MORROW, G.B., BAIK, N., BOOTH, N.A., JALAL, M.M., PARR, R.J. and MUTCH, N.J. 2021. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. Blood [online], 137(2), pages 248-257. Available from: https://doi.org/10.1182/blood.2020007263

Plasminogen activation rates are enhanced by cell surface binding. We previously demonstrated that exogenous plasminogen binds to phosphatidylserine-exposing and spread platelets. Platelets contain plasminogen in their α-granules, but secretion of pl... Read More about Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets..

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. (2020)
Journal Article
WHYTE, C.S., MORROW, G.B., MITCHELL, J.L., CHOWDARY, P. and MUTCH, N.J. 2020. Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. Journal of thrombosis and haemostasis [online], 18(7), pages 1548-1555. Available from: https://doi.org/10.1111/jth.14872

The global pandemic of coronavirus disease 2019 (COVID‐19) is associated with the development of acute respiratory distress syndrome (ARDS), which requires ventilation in critically ill patients. The pathophysiology of ARDS results from acute inflamm... Read More about Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19..

Coagulation status of critically ill patients with and without liver disease assessed using a novel thrombin generation analyzer. (2020)
Journal Article
MORROW, G.B., BEAVIS, J., HARPER, S., BAKER, P., DESBOROUGH, M.J.R., CURRY, N., STANWORTH, S.J. and LAFFAN, M.A. 2020. Coagulation status of critically ill patients with and without liver disease assessed using a novel thrombin generation analyzer. Journal of thrombosis and haemostasis [online], 18(7), pages 1576-1585. Available from: https://doi.org/10.1111/jth.14802

The liver synthesizes the majority of pro- and anti-oagulant and fibrinolytic proteins, and during liver dysfunction synthesis of these proteins is reduced. The end point of conventional hemostatic tests, such as the prothrombin time (PT), occurs whe... Read More about Coagulation status of critically ill patients with and without liver disease assessed using a novel thrombin generation analyzer..