Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract.

Carvalho, Ana L.; Fonseca, Sonia; Miquel-Clopés, Ariadna; Cross, Kathryn; Kok, Khoon-S.; Wegmann, Udo; Gil-Cardoso, Katherine; Bentley, Eleanor G.; Al Katy, Sanaria H.M.; Coombes, Janine L.; Kipar, Anja; Stentz, Regis; Stewart, James P.; Carding, Simon R.

doi:10.1080/20013078.2019.1632100

All Outputs (2)

An open-format enteroid culture system for interrogation of interactions between Toxoplasma gondii and the intestinal epithelium. (2019)
Journal Article
LUU, L., JOHNSTON, L.J., DERRICOTT, H., ARMSTRONG, S.D., RANDLE, N., HARTLEY, C.S., DUCKWORTH, C.A., CAMPBELL, B.J., WASTLING, J.M. and COOMBES, J.L. 2019. An open-format enteroid culture system for interrogation of interactions between Toxoplasma gondii and the intestinal epithelium. Frontiers in cellular and infection microbiology [online], 9, article number 300. Available from: https://doi.org/10.3389/fcimb.2019.00300

When transmitted through the oral route, Toxoplasma gondii first interacts with its host at the small intestinal epithelium. This interaction is crucial to controlling initial invasion and replication, as well as shaping the quality of the systemic i... Read More about An open-format enteroid culture system for interrogation of interactions between Toxoplasma gondii and the intestinal epithelium..

Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. (2019)
Journal Article
CARVALHO, A.L., FONSECA, S., MIQUEL-CLOPÉS, A., CROSS, K., KOK, K.-S., WEGMANN, U., GIL-CARDOSO, K., BENTLEY, E.G., AL KATY, S.H.M., COOMBES, J.L., KIPAR, A., STENTZ, R., STEWART, J.P. and CARDING, S.R. 2019. Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. Journal of extracellular vesicles [online], 8(1), article number 1632100. Available from: https://doi.org/10.1080/20013078.2019.1632100

Gram-negative bacteria naturally produce and secrete nanosized outer membrane vesicles (OMVs). In the human gastrointestinal tract, OMVs produced by commensal Gram-negative bacteria can mediate interactions amongst host cells (including between epith... Read More about Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract..