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Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease. (2020)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2020. Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer's disease. Bioorganic and medical chemistry letters [online], 30(21), article ID 127505. Available from: https://doi.org/10.1016/j.bmcl.2020.127505

A number of novel naphthalimido and phthalimido vanillin derivatives were synthesised, and evaluated as antioxidants and cholinesterase inhibitors in vitro. Antioxidant activity was assessed using DPPH, FRAP, and ORAC assays. All compounds demonstrat... Read More about Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease..

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. (2019)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2019. Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. MedChemComm [online], 10(12), pages 2052-2072. Available from: https://doi.org/10.1039/c9md00337a

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. The number of people suffering from this debilitating disorder is rising at an unprecedented rate, with a subsequent surge in healthcare c... Read More about Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands..