All Outputs (13)

Characterisation of illicit ecstasy and diazepam tablets by colorant identification. (2018)
Journal Article
SHARRENBROCH, L., TOUGH, A. and MATTHEWS, K.H. 2018. Characterisation of illicit ecstasy and diazepam tablets by colorant identification. Analytical methods [online], 10(17), pages 2048-2055. Available from: https://doi.org/10.1039/c7ay02921g

Ecstasy and diazepam are two commonly abused drugs with a high potential for dependence. They are typically available as oral tablets that contain both the drug and other bulk components (excipients). Compositional knowledge of individual tablets off... Read More about Characterisation of illicit ecstasy and diazepam tablets by colorant identification..

Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa. (2018)
Journal Article
O'DRISCOLL, N.H., CUSHNIE, T.P.T., MATTHEWS, K.H. and LAMB, A.J. 2018. Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of escherichia coli and pseudomonas aeruginosa. Archives of microbiology [online], 200(5), pages 793-802. Available from: https://doi.org/10.1007/s00203-018-1485-3

Whilst colistin (polymyxin E) represents the last mainstream treatment option for multi-drug resistant Gram-negative pathogens, details of its mechanism of action remain to be fully resolved. In this study, the effects of sub-inhibitory, inhibitory-b... Read More about Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa..

Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. (2016)
Journal Article
MCKENZIE, B., KAY, G., MATTHEWS, K.H., KNOTT, R. and CAIRNS, D. 2016. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. International journal of pharmaceutics [online], 515(1-2), pages 575-582. Available from: https://doi.org/10.1016/j.ijpharm.2016.10.044

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of... Read More about Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis..

A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry. (2015)
Journal Article
BIBI, S., BREMNER, D.H., MACDOUGALL-HEASMAN, M., REID, R., SIMPSON, K., TOUGH, A., WADDELL, S., STEWART, I.J. and MATTHEWS, K.H. 2015. A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry. Analytical methods [online], 7(20), pages 8597-8604. Available from: https://doi.org/10.1039/C5AY01711D

Increasing numbers of illicit and unlicensed medicines are in general circulation and regularly seized by the police and other regulatory authorities. Forensic identification of seized tablets tends to focus on visual appearance and chromatographic i... Read More about A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry..

A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate. (2015)
Thesis
SARTAWI, Z. 2015. A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate. Robert Gordon University, MRes Thesis.

Polyelectrolytes are charge-carrying polymers. When two oppositely-charged polyelectrolytes are combined in a solution favouring charge expression, a polyelectrolyte complex can result. These complexes have been shown to be useful in the field of dru... Read More about A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate..

The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop® and ImageJ. (2015)
Journal Article
MCKENZIE, B., KAY, G., MATTHEWS, K.H., KNOTT, R.M. and CAIRNS, D. 2015. The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop® and ImageJ. International journal of pharmaceutics [online], 490(1-2), pages 1-8. Available from: https://doi.org/10.1016/j.ijpharm.2015.05.023

A modified hen’s egg chorioallantoic membrane (HET-CAM) test has been developed, combining ImageJ analysis with Adobe® Photoshop®. The irritation potential of an ophthalmic medicine can be quantified using this method, by monitoring damage to blood v... Read More about The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop® and ImageJ..

Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. (2013)
Thesis
MEDU, E.O. 2013. Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. Robert Gordon University, PhD thesis.

Bacterial resistance is an increasing challenge across the world, which means that there is an urgent need for the rational development of antibacterial compounds that have either novel or multiple mechanisms of action. This study demonstrated that t... Read More about Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B..

Suppository formulations as a potential treatment for nephropathic cystinosis. (2012)
Journal Article
BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-3738. Available from: https://doi.org/10.1002/jps.23246

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste... Read More about Suppository formulations as a potential treatment for nephropathic cystinosis..

Antimicrobial wafers as a novel technology for infection control in chronic wounds. (2011)
Thesis
LABOVITIADI, O. 2011. Antimicrobial wafers as a novel technology for infection control in chronic wounds. Robert Gordon University, PhD thesis.

Bacterial contamination and persistent infection is a common cause of impaired wound healing. Generally, non-healing wounds display similar physiological features with regards to mixed bacterial flora, ischemia and production of exudate. The applicat... Read More about Antimicrobial wafers as a novel technology for infection control in chronic wounds..

Formulation studies on cysteamine for the treatment of nephropathic cystinosis. (2011)
Thesis
BUCHAN, B.E. 2011. Formulation studies on cysteamine for the treatment of nephropathic cystinosis. Robert Gordon University, PhD thesis.

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of almost all organs. It is treated by regular oral and topical administration of the aminothiol, cysteamine (Cystagon TM),... Read More about Formulation studies on cysteamine for the treatment of nephropathic cystinosis..

Investigation into the antimicrobial activity of cationic antibacterials. (2011)
Thesis
O'DRISCOLL, N.H. 2011. Investigation into the antimicrobial activity of cationic antibacterials. Robert Gordon University, PhD thesis.

The topic addressed by the 2011 WHOs World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation focussed on the action... Read More about Investigation into the antimicrobial activity of cationic antibacterials..

The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. (2011)
Thesis
GADAD, P.C. 2011. The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. Robert Gordon University, PhD thesis.

Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment o... Read More about The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies..

Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. (2010)
Thesis
IBIE, C.O. 2010. Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. Robert Gordon University, MRes thesis.

Modified-release multiparticulate pellets have been produced by the process of extrusion and spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosi... Read More about Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis..