All Outputs (11)

The molecular contribution of TNF-α in the link between obesity and breast cancer. (2010)
Journal Article
WEICHHAUS, M., BROOM, I. and BERMANO, G. 2011. The molecular contribution of TNF-α in the link between obesity and breast cancer. Oncology reports [online], 25(2), pages 477-483. Available from: https://doi.org/10.3892/or.2010.1099

Obesity is a growing worldwide medical problem, as it pre-disposes the affected hosts to a number of severe diseases, including postmenopausal breast cancer. Obesity development is characterised, amongst others, by aberrant secretion of adipokines. W... Read More about The molecular contribution of TNF-α in the link between obesity and breast cancer..

Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. (2010)
Thesis
IBIE, C.O. 2010. Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. Robert Gordon University, MRes thesis.

Modified-release multiparticulate pellets have been produced by the process of extrusion and spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosi... Read More about Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis..

In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. (2010)
Journal Article
HOSKINS, C., OUAISSI, M., LIMA, S.C., CHENG, W.P., LOUREIRIO, I., MAS, E., LOMBARDO, D., CORDEIRO-DA-SILVA, A., OUAISSI, A. and KONG THOO LIN, P. 2010. In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. Pharmaceutical research [online], 27(12), pages 2694-2703. Available from: https://doi.org/10.1007/s11095-010-0268-6

Purpose: To evaluate the in vitro and in vivo pancreatic anticancer activity of a nano-sized formulation based on novel polyallylamine grafted with 5% mole cholesteryl pendant groups (CH5-PAA). Methods: Insoluble novel anticancer drug, Bisnaphthalimi... Read More about In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer..

In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes. (2010)
Journal Article
CHENG, W.-P., THOMPSON, C., RYAN, S.M., AGUIRRE, T., TETLEY, L. and BRAYDEN, D.J. 2010. In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes. Journal of controlled release [online], 147(2), pages 289-297. Available from: https://doi.org/10.1016/j.jconrel.2010.07.128

The cationic peptide, salmon calcitonin (sCT) was complexed with the cationic amphiphilic polyelectrolyte, poly(allyl)amine, grafted with palmitoyl and quaternary ammonium moieties at pH 5.0 and 7.4 to yield particulates (sCT-QPa). The complexes were... Read More about In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes..

Exploring and evaluating pharmacist prescribing. (2010)
Report
STEWART, D., CUNNINGHAM, S., DIACK, L., MCCAIG, D., MACLURE, K., BOND, C. and GEORGE, J. 2010. Exploring and evaluating pharmacist prescribing. Aberdeen: Robert Gordon University.

This report describes in detail the research conducted by the 'Prescribing Research Group', supported by NES funding. Members of the group are listed on the front cover. Since inception date, this group has been highly active in the field of pharmacy... Read More about Exploring and evaluating pharmacist prescribing..

The characterisation and identification of body fluid proteins for forensic purposes. (2010)
Thesis
VINCINI, L. 2010. The characterisation and identification of body fluid proteins for forensic purposes. Robert Gordon University, PhD thesis.

Advances in DNA technology have led to the extremely sensitive and rapid analysis methods used in forensic science. It can often be crucial to a criminal case to unequivocally identify the body fluid source of DNA. This is of particular importance in... Read More about The characterisation and identification of body fluid proteins for forensic purposes..

Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. (2010)
Thesis
BARRON, G. 2010. Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. Robert Gordon University, PhD thesis.

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaph... Read More about Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system..

The use of novel poly(allylamine) based amphiphilic polymers for drug delivery. (2010)
Thesis
HOSKINS, C. 2010. The use of novel poly(allylamine) based amphiphilic polymers for drug delivery. Robert Gordon University, PhD thesis.

Fourteen novel comb shaped amphiphilic polymers were successfully synthesised to determine the effect of polymer architecture on the potential of these amphiphilic polymers for hydrophobic drug delivery. Polyallylamine (PAA) was grafted with four dif... Read More about The use of novel poly(allylamine) based amphiphilic polymers for drug delivery..

Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. (2010)
Thesis
SKENE, K.E. 2010. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. Robert Gordon University, PhD thesis.

Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive th... Read More about Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation..

Evaluation of methodology for detection and quantification of coliform bacteria and their survival in soil and water. (2010)
Thesis
BANNISTER, E. 2010. Evaluation of methodology for detection and quantification of coliform bacteria and their survival in soil and water. Robert Gordon University, PhD thesis.

In Aberdeenshire, approximately 25,000 people rely on potable water from private water supplies. Many of these supplies are of questionable quality with regards to microbiological contamination, which is often due to a lack of maintenance and protect... Read More about Evaluation of methodology for detection and quantification of coliform bacteria and their survival in soil and water..

The degradation of microcystin-LR using doped visible light absorbing photocatalysts. (2010)
Journal Article
GRAHAM, D., KISCH, H., LAWTON, L.A. and ROBERTSON, P.K.J. 2010. The degradation of microcystin-LR using doped visible light absorbing photocatalysts. Chemosphere [online], 78(9), pages 1182-1185. Available from: https://doi.org/10.1016/j.chemosphere.2009.12.003

Microcystins are one of the primary hepatotoxic cyanotoxins released from cyanobacteria. The presence of these compounds in water has resulted in the death of both humans and domestic and wild animals. Although microcystins are chemically stable tita... Read More about The degradation of microcystin-LR using doped visible light absorbing photocatalysts..