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Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation: towards oral insulin delivery. (2018)
Journal Article
IBIE, C.O., KNOTT, R.M. and THOMPSON, C.J. 2019. Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation: towards oral insulin delivery. Drug development and industrial pharmacy [online], 45(1), pages 67-75. Available from: https://doi.org/10.1080/03639045.2018.1517776

A significant barrier to oral insulin delivery is its enzymatic degradation in the gut. Nano-sized polymer-insulin polyelectrolyte complexes (PECS) have been developed to protect insulin against enzymatic degradation. Poly(allylamine) (Paa) was trime... Read More about Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation: towards oral insulin delivery..

Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy. (2018)
Journal Article
SHARMA, L., LONE, N.A., KNOTT, R.M., HASSAN, A., ABDULLAH, T. 2018. Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy. Food and chemical toxicology [online], 121, pages 283-296. Available from: https://doi.org/10.1016/j.fct.2018.09.011

Non-alcoholic fatty liver disease (NAFLD) is often linked with impaired hepatic autophagy. Here, we studied the alterations in hepatocellular autophagy by high cholesterol and high-fat diet (HC-HF) diet in C57BL/6J mice, and by palmitic acid (PA), in... Read More about Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy..

An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome. (2018)
Thesis
BHATTA, P. 2018. An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome. Robert Gordon University, PhD thesis.

Type 2 diabetes and metabolic syndrome are the metabolic disorders which constitute a major public health problem in both developed and developing countries. Various studies have suggested the genetic susceptibility to the disorders. The main aim of... Read More about An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome..