All Outputs (5)

GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. (2019)
Journal Article
POHL, F., TEIXEIRA-CASTRO, A., COSTA, M.D., LINDSAY, V., FIÚZA-FERNANDES, J., GOUA, M., BERMANO, G., RUSSELL, W., MACIEL, P. and KONG THOO LIN, P. 2019. GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. Frontiers in neuroscience [online], 13, article ID 1091. Available from: https://doi.org/10.3389/fnins.2019.01091

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson’s disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as impor... Read More about GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation..

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. (2019)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2019. Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. MedChemComm [online], 10(12), pages 2052-2072. Available from: https://doi.org/10.1039/c9md00337a

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. The number of people suffering from this debilitating disorder is rising at an unprecedented rate, with a subsequent surge in healthcare c... Read More about Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands..

Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. (2019)
Thesis
SCIPIONI, M. 2019. Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a naturally-occurring phenolic compound, forming the main component of the bean and pod of vanilla orchids. It is widely used as a flavouring agent in food and drinks, and as a preservative in the cosmeti... Read More about Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties..

Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease. (2019)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I.L. and KONG THOO LIN, P. 2019. Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer’s disease. MedChemComm [online], 10(5), pages 764-777. Available from: https://doi.org/10.1039/c9md00048h

Alzheimer’s Disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a “multi-target-directed ligands” (MTDLs) approach for the treatment of this illness ha... Read More about Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease..

The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. (2019)
Thesis
POHL, F. 2019. The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Rapeseed pomace (RSP) is the waste/by-product obtained after edible oil production from Brassica napus and is currently used as animal feed. In an attempt to revalorize this by-product as a potential nutraceutical for the treatment or prevention of n... Read More about The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases..