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Cannabidiol exerts species selective cardioprotective effects in anthracycline-induced cardiotoxicity. (2019)
Presentation / Conference
BARRON, G., WAINWRIGHT, C. and WALSH, S.K. 2019. Cannabidiol exerts species selective cardioprotective effects in anthracycline-induced cardiotoxicity. Presented at the 2019 Pharmacology conference, 15-17 December 2019, Edinburgh, UK.

Anthracyclines such as doxorubicin are effective chemotherapy agents, however a severe and common side effect of this treatment is anthracycline induced cardiotoxicity (AIC), which damages the heart muscle severely impacting its ability to pump and c... Read More about Cannabidiol exerts species selective cardioprotective effects in anthracycline-induced cardiotoxicity..

l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway. (2019)
Journal Article
ROBERTSON-GRAY, O.J., WALSH, S.K., RYBERG, E., JÖNSSON-RYLANDER, A.-C., LIPINA, C. and WAINWRIGHT, C.L. 2019. l‐α‐Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK‐dependent pathway. Pharmacology research and perspectives [online], 7(3), article ID e00487. Available from: https://doi.org/10.1002/prp2.487

The phospholipid l-α-lysophosphatidylinositol (LPI), an endogenous ligand for GPR55, is elevated in patients with acute coronary syndrome, and a GPR55 antagonist cannabidiol (CBD) reduces experimental ischemia/reperfusion (I/R) injury. While LPI acti... Read More about l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway..

Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione. (2019)
Journal Article
SKENE, K., WALSH, S.K., OKAFOR, O., GODSMAN, N., BARROWS, C., MEIER, P., GORDON, M.J., BEATTIE, J.H. and WAINWRIGHT, C.L. 2019. Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione. British journal of nutrition [online], 121(9), pages 961-973. Available from: https://doi.org/10.1017/S0007114519000230

Zinc (Zn) plays an important role in maintaining the anti-oxidant status within the heart, and helps to counter the acute redox stress that occurs during myocardial ischaemia and reperfusion. Individuals with low zinc (Zn) levels are at greater risk... Read More about Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione..