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Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters. (1999)
Journal Article
LAWTON, L.A. and ROBERTSON, P.K.J. 1999. Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters. Chemical society reviews [online], 28(4), pages 217-224. Available from: https://doi.org/10.1039/A805416I

The incidence of cyanobacterial blooms in freshwaters, including drinking water reservoirs, has increased over the past few decades due to rising nutrient levels. Microcystins are hepatotoxins released from cyanobacteria and have been responsible for... Read More about Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters..

Purification, detection and biological effects of cyanobacterial toxins. (1999)
Thesis
MCELHINEY, J. 1999. Purification, detection and biological effects of cyanobacterial toxins. Robert Gordon University, PhD thesis.

Dense growths of cyanobacteria (blue-green algae), known as blooms, commonly occur in fresh and brackish waters throughout the world. Cyanobacterial blooms present a considerable threat to water quality as many species produce toxins. These toxins ha... Read More about Purification, detection and biological effects of cyanobacterial toxins..

Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction. (1999)
Thesis
LANDRÉ, J.B.P. 1999. Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction. Robert Gordon University, PhD thesis.

Mesophilic Aeromonas are opportunistic human pathogens which produce a wide range of virulence factors and have been isolated from both untreated and chlorinated drinking waters. The presence of these microorganisms in the distribution systems sugges... Read More about Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction..

Fermentation of resistant starch: implications for colonic health in the monogastric animal. (1999)
Thesis
REID, C.-A. 1999. Fermentation of resistant starch: implications for colonic health in the monogastric animal. Robert Gordon University, PhD thesis.

Retrograded starches are commonly found in foods due to the production and/or processing conditions they have received prior to consumption. These resistant starches escape digestion in the small intestine and are fermented in the colon by the microf... Read More about Fermentation of resistant starch: implications for colonic health in the monogastric animal..

Cytochrome P450 CYP3A in human renal cell cancer. (1999)
Journal Article
MURRAY, G.I., MCFADYEN, M.C.E., MITCHELL, R.T., CHEUNG, Y.-L., KERR, A.C. and MELVIN, W.T. 1999. Cytochrome P450 CYP3A in human renal cell cancer. British journal of cancer [online], 79(11-12), pages 1836-1842. Available from: https://doi.org/10.1038/sj.bjc.6690292

Renal cell cancer is the main malignant tumour of the kidney and has an increasing incidence. This type of tumour has a poor prognosis and shows intrinsic resistance to several anti-cancer drugs. The CYP3A P450 family, which consists of three closely... Read More about Cytochrome P450 CYP3A in human renal cell cancer..

Cytochrome P450 CYP1B1 in breast cancer. (1998)
Presentation / Conference
MURRAY, G.I., BUCHAN, S., MCFADYEN, M.C.E., MILLER, I.D., PAYNE, S. and MELVIN, W.T. 1998. Cytochrome P450 CYP1B1 in breast cancer. Presented at the 1998 Joint special conference of the British Association for Cancer Research and the Royal Society of Medicine (Oncology Section), 7-8 December 1998, London, UK.

This poster gives an overview of recent research into cytochrome P450 CYP1B1, which has previously been shown to present increased expression in several types of human cancer. This study specifically used immunohistochemistry to investigate the expre... Read More about Cytochrome P450 CYP1B1 in breast cancer..

Development and characterization of biodegradable microspheres containing selected antimycobacterials. (1998)
Thesis
BAIN, D.F. 1998. Development and characterization of biodegradable microspheres containing selected antimycobacterials. Robert Gordon University, PhD thesis.

Prolonged therapy required to effectively treat mycobacterial infection frequently results in severe dose-limiting side-effects and drug resistance due to patient non-compliance with protracted dosage regimens. Biodegradable poly-a-hydroxy acid micro... Read More about Development and characterization of biodegradable microspheres containing selected antimycobacterials..

An evaluation of the use and efficacy of analgesics in the management of chronic pain in the community. (1998)
Thesis
READ, R.W. 1998. An evaluation of the use and efficacy of analgesics in the management of chronic pain in the community. Robert Gordon University, PhD thesis.

The main aims of this research were to evaluate the use and efficacy of analgesics in the management of chronic pain in the community and to investigate the role of the pharmacist in optimising health outcomes relating to chronic pain by assessing th... Read More about An evaluation of the use and efficacy of analgesics in the management of chronic pain in the community..

Processes influencing the destruction of microcystin-LR by TiO2 photocatalysis. (1998)
Journal Article
ROBERTSON, P.K.J., LAWTON, L.A., CORNISH, B.J.P.A. and JASPARS, M. 1998. Processes influencing the destruction of Microcystin-LR by TiO2 photocatalysis. Journal of photochemistry and photobiology A: chemistry [online], 116(3), pages 215-219. Available from: https://doi.org/10.1016/S1010-6030(98)00312-8

We have previously reported the effectiveness of TiO2 photocatalysis in the destruction of the cyanotoxin microcystin-LR [P.K.J. Robertson, L.A. Lawton, B. Münch, J. Rouzade, J. Chem. Soc., Chem. Commun., 4 (1997) 393; P.K.J. Robertson, L.A. Lawton,... Read More about Processes influencing the destruction of microcystin-LR by TiO2 photocatalysis..

Implementing formulary recommendations in primary care: effect on patient outcomes. (1998)
Thesis
STEWART, D.C. 1998. Implementing formulary recommendations in primary care: effect on patient outcomes. Robert Gordon University, PhD thesis.

This research aimed to measure the effect on health outcomes of implementing selected recommendations of the Grampian Joint Drug Formulary in primary care. Antibiotics used in the treatment of uncomplicated lower urinary tract infections (UTIs), ulce... Read More about Implementing formulary recommendations in primary care: effect on patient outcomes..

The behaviour of the people of NE Thailand towards medicines for self-treatment. (1997)
Thesis
CHADBUNCHACHAI, S. 1997. The behaviour of the people of NE Thailand towards medicines for self-treatment. Robert Gordon University, PhD thesis.

Musculoskeletal pain is one of the most common illnesses among the people of north-eastern Thailand and is commonly treated by self-medication. Ya-chud (several medicines together in a small plastic bag) for the treatment of musculoskeletal pain is a... Read More about The behaviour of the people of NE Thailand towards medicines for self-treatment..

Cytochrome P450 in human brain tumours. (1997)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in human brain tumours. Presented at the 1997 Joint winter meeting of the British Association for Cancer Research, the Association of Cancer Physicians and the Royal Society of Medicine (Oncology Section), 27-28 November 1997, London, UK.

This presentation reports on a study investigating the presence and cellular localization of individual families of cytochrome P450 enzymes, in both normal brain and primary brain tumours. The immunoreactivity of individual P450s was identified using... Read More about Cytochrome P450 in human brain tumours..

Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen. (1997)
Thesis
SUJJA-AREEVATH, J. 1997. Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen. Robert Gordon University, PhD thesis.

Mini-matrix multiple unit dosage forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gu... Read More about Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen..

Studies on the stability and activity of polymyxin B solutions. (1997)
Thesis
SAOHIN, W. 1997. Studies on the stability and activity of polymyxin B solutions. Robert Gordon University, PhD thesis.

The correlation between the chemical stability and the microbiological activity of polymyxin B in phosphate buffer pH 6.0 and in proprietary eye drops was evaluated. High Performance Liquid Chromatography (HPLC) was used to quantify the amount of the... Read More about Studies on the stability and activity of polymyxin B solutions..

Cytochrome P450 in normal human brain and brain tumours. (1997)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in normal human brain and brain tumours. Presented at the July 1997 Biochemical Society meeting, 29-31 July 1997, Dundee, UK.

Cytochromes P450 are a multi-gene family of constitutive and inducible haem-containing enzymes, with a critical role in the oxidative metabolism of a wide range of environmental chemicals - including carcinogens, toxins and therapeutic drugs. P450s m... Read More about Cytochrome P450 in normal human brain and brain tumours..

Isotopic studies of selenium in environmental samples. (1997)
Thesis
MACLEOD, F. 1997. Isotopic studies of selenium in environmental samples. Robert Gordon University, PhD thesis.

Selenium has aroused much interest in the last decade. It is an essential trace element for man and animals and has been found to be the cofactor in two enzyme systems. The first, glutathionine peroxidase, acts as an anti-oxidant by destroying peroxi... Read More about Isotopic studies of selenium in environmental samples..

Destruction of cyanobacterial toxins by semiconductor photocatalysis. (1997)
Journal Article
ROBERTSON, P.K.J., LAWTON, L.A., MÜNCH, B. and ROUZADE, J. 1997. Destruction of cyanobacterial toxins by semiconductor photocatalysis. Chemical communications [online], 4, pages 393-394. Available from: https://doi.org/10.1039/A607965B

The rapid destruction of microcystin, a cyanobacterial toxin, using a titanium dioxide photocatalyst is observed; the process is extremely efficient with high concentrations of toxin completely undetectable within 10-40 min, depending on the initial... Read More about Destruction of cyanobacterial toxins by semiconductor photocatalysis..

6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] (1995)
Dataset
VAN MEERVELT, L., KONG THOO LIN, P. and BROWN, D.M. 1995. 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] Acta crystallographica section C: crystal structure communications [online], 51(7), pages 1347-1350. Available from: https://doi.org/10.1107/s0108270195000096

The title compound, C15H19N3O7 (P), crystallizes with two molecules in the asymmetric unit which differ in sugar and oxazino ring puckering; both occur as the imino tautomer and form P;P wobble base pairs. The supporting information for the published... Read More about 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset].

Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset] (1995)
Dataset
MOORE, M.H., VAN MEERVELT, L., SALISBURY, S.A., KONG THOO LIN, P. and BROWN, D.M. 1995. Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset]. Hosted on Worldwide Protein Data Bank (wwPDB) [online], 223D. Available from: https://doi.org/10.2210/pdb223d/pdb

The pyrimidine nucleobase analogue 6H,8H-3,4-dihydropyrimido[4,5-c]-[1,2]oxazin-7-one (P) is a mimic both of cytosine and thymine, since it can form stable hydrogen-bonded base-pairs with either guanine or adenine. To investigate the geometric proper... Read More about Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset].

A stability study of dithranol in solution, formulations and in normal and psoriatic skin. (1994)
Thesis
LUBWIKA, P. 1994. A stability study of dithranol in solution, formulations and in normal and psoriatic skin. Robert Gordon University, PhD thesis.

For more than 100 years dithranol has been successfully used for the treatment of psoriasis . It is still not fully understood, however, how it exerts its antipsoriatic effect. From the information available to date it is clear that the actual proces... Read More about A stability study of dithranol in solution, formulations and in normal and psoriatic skin..