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Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset] (1995)
Dataset
MOORE, M.H., VAN MEERVELT, L., SALISBURY, S.A., KONG THOO LIN, P. and BROWN, D.M. 1995. Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset]. Hosted on Worldwide Protein Data Bank (wwPDB) [online], 223D. Available from: https://doi.org/10.2210/pdb223d/pdb

The pyrimidine nucleobase analogue 6H,8H-3,4-dihydropyrimido[4,5-c]-[1,2]oxazin-7-one (P) is a mimic both of cytosine and thymine, since it can form stable hydrogen-bonded base-pairs with either guanine or adenine. To investigate the geometric proper... Read More about Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset].

A stability study of dithranol in solution, formulations and in normal and psoriatic skin. (1994)
Thesis
LUBWIKA, P. 1994. A stability study of dithranol in solution, formulations and in normal and psoriatic skin. Robert Gordon University, PhD thesis.

For more than 100 years dithranol has been successfully used for the treatment of psoriasis . It is still not fully understood, however, how it exerts its antipsoriatic effect. From the information available to date it is clear that the actual proces... Read More about A stability study of dithranol in solution, formulations and in normal and psoriatic skin..

Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. (1992)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1992. Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. Nucleic acids research [online], 20(19), pages 5149-5152. Available from: https://doi.org/10.1093/nar/20.19.5149

Heptadecaoligodeoxyribonudeotides containing one or more of the bases, 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one (P), 2-amino-6-methoxyaminopurine (K), and hypoxanthine (I) and combinations of P with K and I have been synthesised on a DNA sy... Read More about Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction..

Enhanced microcomputer operation of X-ray diffractometers and subsequent applications. (1992)
Thesis
SUTHERLAND, N.S. 1992. Enhanced microcomputer operation of X-ray diffractometers and subsequent applications. Robert Gordon University, PhD thesis.

The work described within this thesis is mainly concerned with the solution and refinement of the molecular structures of a variety of novel compounds. A number of X-ray and neutron diffractometers have been utilised for the analysis of specific comp... Read More about Enhanced microcomputer operation of X-ray diffractometers and subsequent applications..

The synthesis and structural examination of 3alpha, 5-cyclo-5alpha-androstane steroids. (1992)
Thesis
GIBB, B.C. 1992. The synthesis and structural examination of 3alpha, 5-cyclo-5alpha-androstane steroids. Robert Gordon University, PhD thesis.

The work described in this thesis is based on the synthesis and structural examination of several cyclosteroids. The a-aromatic steroid 3a, 5-cyclo-5c-androstan-6beta-ol- 17-one was used as a lead compound in an attempt to produce, in particular, the... Read More about The synthesis and structural examination of 3alpha, 5-cyclo-5alpha-androstane steroids..

Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. (1991)
Journal Article
KELLY, D., KING, T.P., BROWN, D.S. and MCFADYEN, M. 1991. Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. Reproduction nutrition development [online], 31(1), pages 73-80. Available from: https://doi.org/10.1051/rnd:19910107

Previous studies have suggested that luminal polyamines can directly influence intestinal differentiation of neonatal rats. The present investigation has demonstrated the presence of high levels of polyamines in porcine milk and in the intestinal tis... Read More about Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling..

The development and evaluation of a hydrogel drug delivery system for dithranol. (1991)
Thesis
PRIPREM, A. 1991. The development and evaluation of a hydrogel drug delivery system for dithranol. Robert Gordon Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1744913

Dithranol is widely used in the treatment of psoriasis, but it has the drawbacks of instability, staining of skin and clothes, and irritation, especially of non-involved skin. A polyurethaneurea hydrogel in sheet form has been used to investigate the... Read More about The development and evaluation of a hydrogel drug delivery system for dithranol..

The development of analytical methods to elucidate the chemical forms of Cu, Zn, Cd and Pb in soil contaminated by sewage sludge and other effluents. (1990)
Thesis
PARK, J.S. 1990. The development of analytical methods to elucidate the chemical forms of Cu, Zn, Cd and Pb in soil contaminated by sewage sludge and other effluents. Council for National Academic Awards, PhD thesis.

The contents of this thesis describes the development of an analytical method to determine the chemical speciation of heavy metals in soils contaminted by sewage sludge and distillery wastes. Chapter one serves as an introduction discussing the vario... Read More about The development of analytical methods to elucidate the chemical forms of Cu, Zn, Cd and Pb in soil contaminated by sewage sludge and other effluents..

Pattern of gastric emptying in the pig: relation to feeding. (1990)
Journal Article
GREGORY, P.C., MCFADYEN, M. and RAYNER, D.V. 1990. Pattern of gastric emptying in the pig: relation to feeding. British journal of nutrition [online], 64(1), pages 45-58. Available from: https://doi.org/10.1079/bjn19900008

The aims of the present study were to compare the gastric emptying of dry matter (DM) and liquids during the feeding period with that following meal consumption, to clarify the relationship between feeding and gastric emptying, and to investigate how... Read More about Pattern of gastric emptying in the pig: relation to feeding..

Interactions of platinum compounds with heterocyclic bases. (1990)
Thesis
TAYLOR, L.M. 1990. Interactions of platinum compounds with heterocyclic bases. Robert Gordon's Institute of Technology, PhD thesis.

It is generally accepted that platinum antitumoar drugs bind, preferentially, to Guanine N7 in DNA. Thus the kinetics of formation and the energetics of dissociation of platinum-nitrogen bonding have been investigated, using simple model bases, namel... Read More about Interactions of platinum compounds with heterocyclic bases..

The provision of health care in remote hostile environments. (1990)
Thesis
BREBNER, J.A. 1990. The provision of health care in remote hostile environments. Robert Gordon Institute of Technology, PhD thesis.

The health care of those who work in remote places associated with hostile environments is reviewed, concentrating on the offshore oil industry and Antarctic populations. An understanding of associated environmental hazards is essential for adequate... Read More about The provision of health care in remote hostile environments..

Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. (1989)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1989. Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic acids research [online], 17(24), pages 10373-10383. Available from: https://doi.org/10.1093/nar/17.24.10373

The synthesis of the deoxynucleoside derived from the base P, 6H, 8H-3, 4-dihydro-pyrimido[4, 5-c][1, 2] oxazin-7-one, 2, and its introduction by established phosphoramidite and H-phosphonate chemistry into oligonucleotides is described. The melting... Read More about Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues..

Regulation of stomach emptying in pigs. (1987)
Presentation / Conference
GREGORY, P.C., MCFADYEN, M. and RAYNER, D.V. 1987. Regulation of stomach emptying in pigs. Presented at the 1987 Cambridge meeting of the Physiological Society, 18-19 September 1987, Cambridge, UK.

This presentation reports on three experiments into the stomach emptying of pigs during feeding. Each experiment measured the emptying of both solids and liquids from the stomach using a gastric evacuation technique. Two of the experiments also invol... Read More about Regulation of stomach emptying in pigs..

The determination of drug stability by HPLC assay of degradation products. (1986)
Thesis
SHIVJI, A.S.H. 1986. The determination of drug stability by HPLC assay of degradation products. Robert Gordon's Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1993300

This work evaluates the advantages in drug stability testing of following the decomposition by analysis of decomposition products. Conventional methods of drug stability testing are criticised and the limitations are shown to be largely a result of a... Read More about The determination of drug stability by HPLC assay of degradation products..

An investigation of some factors affecting transdermal permeation. (1985)
Thesis
AL-SAIDAN, S.M.H. 1985. An investigation of some factors affecting transdermal permeation. Robert Gordon's Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1993284

Factors affecting transdermal permeation were investigated using Differential Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Ana... Read More about An investigation of some factors affecting transdermal permeation..

Study of the pharmacological modification of neuroendocrine mechanisms controlling ovulation in the rat. (1982)
Thesis
STEWART, A.W. 1982. Study of the pharmacological modification of neuroendocrine mechanisms controlling ovulation in the rat. Robert Gordon's Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1993302

The synthetic steroid, RMI 12,936 (17beta-hydroxy-7alpha-methyl-androst-5-en-3-one) inhibits ovulation in the rat. This study investigated the mechanism of action of the drug. The results showed that administration at or before 01:00h on proestrus bl... Read More about Study of the pharmacological modification of neuroendocrine mechanisms controlling ovulation in the rat..

The growth, physiology and intermediary metabolism of bacillus stearothermophilus. (1981)
Thesis
SIVASUBRAMANIAN, S. 1981. The growth, physiology and intermediary metabolism of bacillus stearothermophilus. Robert Gordon's Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1993306

The aims of this work were to determine whether a functional tricarboxylic acid (TCA) cycle was present in vegetative cells of B. stearothermophilus, and to understand the effects of growth conditions on the carbohydrate metabolism and cytochrome con... Read More about The growth, physiology and intermediary metabolism of bacillus stearothermophilus..

Investigation of the role of smooth muscle function in egg transport in the mouse oviduct. (1979)
Thesis
LEE, B. 1979. Investigation of the role of smooth muscle function in egg transport in the mouse oviduct. Robert Gordon's Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1993282

The time course of egg transport along the mouse oviduct is important for successful implantation to occur. It is generally accepted that variations in the innate contractile activity of the oviduct musculature regulate the rate of egg transport, but... Read More about Investigation of the role of smooth muscle function in egg transport in the mouse oviduct..

The syntheses and reactivity of 6- and 8-azaindolizines. (1977)
Thesis
SHAND, C.A. 1977. The synthesis and reactivity of 6- and 8-azaindolizines. Robert Gordon's Institute of Technology, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1993228

Synthetic routes leading to indolitine and its mono-aza derivatives, and the reactivity of these systems have been briefly reviewed. A number of simple alkyl, aryl, methoxy and chloro substituted 6- and 8- azaindolizines have been synthesised via the... Read More about The syntheses and reactivity of 6- and 8-azaindolizines..