All Outputs (71)

Phosphate and nitrate supplementations to evaluate the effect on cell biomass, intra and extracellular nodularin and nodulopeptin 901 produced by the cyanobacterium Nodularia spumigena KAC 66. (2019)
Journal Article
HAMEED, S., LAWTON, L.A. and EDWARDS, C. 2020. Phosphate and nitrate supplementations to evaluate the effect on cell biomass, intra and extracellular nodularin and nodulopeptin 901 produced by the cyanobacterium Nodularia spumigena KAC 66. Journal of applied phycology [online], 32(2), pages 937-950. Available from: https://doi.org/10.1007/s10811-019-02008-z

Blooms of the cyanobacterium Nodularia spumigena occur regularly in the Baltic Sea typically producing a wide range of bioactive peptides including the hepatotoxin nodularin (NOD), spumigins, anabaenopeptins and nodulopeptins (molecular weights: 917,... Read More about Phosphate and nitrate supplementations to evaluate the effect on cell biomass, intra and extracellular nodularin and nodulopeptin 901 produced by the cyanobacterium Nodularia spumigena KAC 66..

Daphnia magna exudates impact physiological and metabolic changes in microcystis aeruginosa. (2019)
Journal Article
SAVIC, G.B., EDWARDS, C., BRIAND, E., LAWTON, L., WIEGAND, C. and BORMANS, M. 2019. Daphnia magna exudates impact physiological and metabolic changes in microcystis aeruginosa. Toxins [online], 11(7), article number 421. Available from: https://doi.org/10.3390/toxins11070421

While the intracellular function of many toxic and bioactive cyanobacterial metabolites is not yet known, microcystins have been suggested to have a protective role in the cyanobacterial metabolism, giving advantage to toxic over nontoxic strains und... Read More about Daphnia magna exudates impact physiological and metabolic changes in microcystis aeruginosa..

Exploring the potential resource recovery from pot ale utilising microalgae and novel LED photobioreactors. (2019)
Thesis
MCNERNEY, C.C. 2019. Exploring the potential resource recovery from pot ale utilising microalgae and novel LED photobioreactors. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Pot ale is a protein-rich, high-carbon and acidic (pH 3.5) by-product of the whisky industry. With 4.9 million tonnes of pot ale being produced per annum in Scotland alone, it presents a difficult disposal challenge for the industry. Pot ale has high... Read More about Exploring the potential resource recovery from pot ale utilising microalgae and novel LED photobioreactors..

A European multi lake survey dataset of environmental variables, phytoplankton pigments and cyanotoxins. (2018)
Journal Article
MANTZOUKI, E., CAMPBELL, J., VAN LOON, E.E., VISSER, P. and IBELINGS, B. 2018. A European multi lake survey dataset of environmental variables, phytoplankton pigments and cyanotoxins. Scientific data [online], 5, article ID 180226. Available from: https://doi.org/10.1038/sdata.2018.226

Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face mult... Read More about A European multi lake survey dataset of environmental variables, phytoplankton pigments and cyanotoxins..

Enhancing photocatalytic degradation of the cyanotoxin microcystin-LR with the addition of sulfate-radical generating oxidants. (2018)
Journal Article
ANTONIOU, M.G., BORAEI, I., SOLAKIDOU, M., DELIGIANNAKIS, Y., ABHISHEK, M., LAWTON, L.A. and EDWARDS, C. 2018. Enhancing photocatalytic degradation of the cyanotoxin microcystin-LR with the addition of sulfate-radical generating oxidants. Journal of hazardous materials [online], 360, pages 461-470. Available from: https://doi.org/10.1016/j.jhazmat.2018.07.111

This study investigated the coupling of sulfate radical generating oxidants, (persulfate, PS and peroxymonosulfate, PMS) with TiO2 photocatalysis for the degradation of microcystin-LR (MC-LR). Treatment efficiency was evaluated by estimating the elec... Read More about Enhancing photocatalytic degradation of the cyanotoxin microcystin-LR with the addition of sulfate-radical generating oxidants..

Cyanopeptolins with trypsin and chymotrypsin inhibitory activity from the cyanobacterium nostoc edaphicum CCNP1411. (2018)
Journal Article
MAZUR-MARZEC, H., FIDOR, A., CEGLOWSKA, M., WIECZERZAK, E., KROPIDLOWSKA, M., GOUA, M., MACASKILL, J. and EDWARDS, C. 2018. Cyanopeptolins with trypsin and chymotrypsin inhibitory activity from the cyanobacterium nostoc edaphicum CCNP1411. Marine drugs [online], 16(7), article number 220. Available from: https://doi.org/10.3390/md16070220

Cyanopeptolins (CPs) are one of the most frequently occurring cyanobacterial peptides, many of which are inhibitors of serine proteases. Some CP variants are also acutely toxic to aquatic organisms, especially small crustaceans. In this study, thirte... Read More about Cyanopeptolins with trypsin and chymotrypsin inhibitory activity from the cyanobacterium nostoc edaphicum CCNP1411..

Temperature effects explain continental scale distribution of cyanobacterial toxins. (2018)
Journal Article
MANTZOUKI, E., LÜRLING, M., FASTNER, J., DE SENERPONT DOMIS, L., IBELINGS, B.W., TEURLINCX, S. and CHMURA, D. 2018. Temperature effects explain continental scale distribution of cyanobacterial toxins. Toxins [online], 10(4), article number 156. Available from: https://doi.org/10.3390/toxins10040156

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other c... Read More about Temperature effects explain continental scale distribution of cyanobacterial toxins..

Cell lysis and detoxification of cyanotoxins using a novel combination of microbubble generation and plasma microreactor technology for ozonation. (2018)
Journal Article
PANDHAL, J., SISWANTO, A., KUVSHINOV, D., ZIMMERMAN, W.B., LAWTON, L. and EDWARDS, C. 2018. Cell lysis and detoxification of cyanotoxins using a novel combination of microbubble generation and plasma microreactor technology for ozonation. Frontiers in microbiology [online], 9, article number 678. Available from: https://doi.org/10.3389/fmicb.2018.00678

There has been a steady rise in the global incidences of algal blooms and, worryingly, there is increasing evidence that changes in the global climate are leading to a shift toward cyanobacterial blooms. Many cyanobacterial genera are harmful, produc... Read More about Cell lysis and detoxification of cyanotoxins using a novel combination of microbubble generation and plasma microreactor technology for ozonation..

Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. (2017)
Journal Article
TURNER, A.D., WAACK, J., LEWIS, A., EDWARDS, C. and LAWTON, L. 2018. Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. Journal of chromatography B [online], 1074-1075, pages 111-123. Available from: https://doi.org/10.1016/j.jchromb.2017.12.032

A simple, rapid UHPLC-MS/MS method has been developed and optimised for the quantitation of microcystins and nodularin in wide variety of sample matrices. Microcystin analogues targeted were MC-LR, MC-RR, MC-LA, MC-LY, MC-LF, LC-LW, MC-YR, MC-WR, [As... Read More about Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders..

Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis. (2017)
Thesis
WAACK, J. 2017. Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis. Robert Gordon University, PhD thesis.

Cyanobacteria produce a variety of secondary metabolites that possess - amongst other things - antifungal, antibacterial and antiviral properties. Being primary producers, they are also a vital component within the food web. However, certain strains... Read More about Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis..

Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66. (2017)
Journal Article
HAMEED, S., LAWTON, L.A., EDWARDS, C., KHAN, A., FAROOQ, U. and KHAN, F.A. 2017. Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66. Journal of applied phycology [online], 29(4), pages 1801-1810. Available from: https://doi.org/10.1007/s10811-017-1115-5

Nodularia spumigena is one of the dominant toxic cyanobacteria which produce blooms in the Baltic Sea, a brackish water body, particularly in late summer. Nodularia spp. are known to produce hepatotoxic nodularins (NODs) and other bioactive peptides... Read More about Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66..

Hepatotoxic-microcystins in two drinking water reservoirs in the central region of Ghana. (2017)
Journal Article
ADDICO, G.N.D., LAWTON, L. and EDWARDS, C. 2017. Hepatotoxic-microcystins in two drinking water reservoirs in the central region of Ghana. Toxicology and forensic medicine [online], 2(1), pages 1-11. Available from: https://doi.org/10.17140/TFMOJ-2-111

Background: Microcystins are cyclic peptides containing seven amino acids with the condensation of two terminal amino acids of the linear peptide to form a cyclic compound. The cyclic nature of microcystins suggests that they are highly stable in wat... Read More about Hepatotoxic-microcystins in two drinking water reservoirs in the central region of Ghana..

Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides. (2017)
Journal Article
PHOTOS-JONES, E., EDWARDS, C., HANER, F., LAWTON, L., KEAN, C., LEANORD, A. and PERDIKATSIS, V. 2017. Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides. Geological society: special publications. Geology and medicine: historical connections [online], 452, pages 141-153. Available from: https://doi.org/10.1144/SP452.6

This paper presents the scientific investigation of three Lemnian sphragides (terra sigillata), a famed medicinal clay (earth) of antiquity, dated to the 16th-17th century, and presently in the collection of the Museum for the History of Pharmacy of... Read More about Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides..

Evidence for functional drift of bacterial isolates in response to cyanobacterial microcystin-lr and multiple peptide degradation in paucibacter toxinivorans. (2016)
Thesis
KREITZ, J. 2016. Evidence for functional drift of bacterial isolates in response to cyanobacterial microcystin-lr and multiple peptide degradation in paucibacter toxinivorans. Robert Gordon University, MPhil thesis.

Bacterial bioremediation has been proposed as an efficient, low cost and ecologically safe method to clean vital water reservoirs from cyanobacterial peptide toxins microcystins (MCs). In previous work carried out in 2008 several bacteria were isolat... Read More about Evidence for functional drift of bacterial isolates in response to cyanobacterial microcystin-lr and multiple peptide degradation in paucibacter toxinivorans..

Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors. (2016)
Journal Article
LANCE, E., DESPRAT, J., HOLBECH, B.F., GERARD, C., BORMANS, M., LAWTON, L.A., EDWARDS, C. and WIEGAND, C. 2016. Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors. Aquatic toxicology [online], 177, pages 116-124. Available from: https://doi.org/10.1016/j.aquatox.2016.05.024

Freshwater gastropods are increasingly exposed to multiple stressors in the field such as the herbicide glyphosate in Roundup formulations and cyanobacterial blooms either producing or not producing microcystins (MCs), potentially leading to interact... Read More about Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors..

Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning. (2016)
Journal Article
DELGADO-BAQUERIZO, M., GIARAMIDA, L., REICH, P.B., KHACHANE, A.N., HAMONTS, K., EDWARDS, C., LAWTON, L.A. and SINGH, B.K. 2016. Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning. Journal of ecology [online], 104(4), pages 936-946. Available from: https://doi.org/10.1111/1365-2745.12585

1. Biodiversity is declining worldwide with detrimental effects on ecosystems. However, we lack a quantitative understanding of the shape of the relationship between microbial biodiversity and ecosystem function (BEF). This limits our understanding o... Read More about Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning..

An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806. (2016)
Thesis
ARIF ABDUL RAHMAN, T. 2016. An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806. Robert Gordon University, PhD thesis.

Cyanobacteria are one of the oldest forms of photosynthetic life and may have contributed significantly to the evolution of oxygen into the then anoxic environment. Cyanobacteria are also one of the best sources of natural secondary metabolites (cyan... Read More about An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806..

A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction. (2016)
Journal Article
FAASSEN, E.J., ANTONIOU, M.G., BEEKMAN-LUKASSEN, W., BLAHOVA, L., CHERNOVA, E., CHRISTOPHORIDIS, C., COMBES, A., EDWARDS, C., FASTNER, J., HARMSEN, J., HISKIA, A., ILAG, L.L., KALOUDIS, T., LOPICIC, S., LURLING, M., MAZUR-MARZEC, H., MERILUOTO, J., POROJAN, C., VINER-MOZZINI, Y. and ZGUNA, N. 2016. A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction. Marine drugs [online], 14(3), article 45. Available from: https://doi.org/10.3390/md14030045

Exposure to β-Ν-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. Analytical chemistry plays a crucial role in determining human BMAA exposure and the associat... Read More about A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction..

Rapid bioassay-guided isolation of antibacterial clerodane type diterpenoid from Dodonaea viscosa (L.) Jaeq. (2015)
Journal Article
KHURRAM, M., LAWTON, L.A., EDWARDS, C., IRITI, M., HAMEED, A., KHAN, M.A., KHAN, F.A. and RAHMAN, S.U. 2015. Rapid bioassay-guided isolation of antibacterial clerodane type diterpenoid from Dodonaea viscosa (L.) Jaeq. International journal of molecular science [online], 16(9), pages 20290-20307. Available from: https://doi.org/10.3390/ijms160920290

Plant extracts are complex matrices and, although crude extracts are widely in use, purified compounds are pivotal in drug discovery. This study describes the application of automated preparative-HPLC combined with a rapid off-line bacterial bioassay... Read More about Rapid bioassay-guided isolation of antibacterial clerodane type diterpenoid from Dodonaea viscosa (L.) Jaeq..

Photocatalytic degradation of eleven microcystin variants and nodularin by TiO2 coated glass microspheres. (2015)
Journal Article
PESTANA, C.J., EDWARDS, C., PRABHU, R., ROBERTSON, P.K.J. and LAWTON, L.A. 2015. Photocatalytic degradation of eleven microcystin variants and nodularin by TiO2 coated glass microspheres. Journal of hazardous materials [online], 300, pages 347-353. Available from: https://doi.org/10.1016/j.jhazmat.2015.07.016

Microcystins and nodularin are toxic cyanobacterial secondary metabolites produced by cyanobacteria that pose a threat to human health in drinking water. Conventional water treatment methods often fail to remove these toxins. Advanced oxidation proce... Read More about Photocatalytic degradation of eleven microcystin variants and nodularin by TiO2 coated glass microspheres..