Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity.

Weichhaus, M.; Broom, J.; Wahle, K.; Bermano, G.

Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence. (2018)
Journal Article
DONADIO, J.L.S., LIU, L., FREEMAN, V.L., EKOUE, D.N., DIAMOND, A.M. and BERMANO, G. 2018. Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence. Prostate [online], 79(5), pages 462-467. Available from: https://doi.org/10.1002/pros.23752

Background: NKX3.1 is a tumor suppressor frequently lost in prostate cancer. Previous studies by others indicated that the risks associated with reduced NKX3.1 levels can be enhanced by anti-oxidant supplementation. Selenium is an essential component... Read More about Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence..

An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome. (2018)
Thesis
BHATTA, P. 2018. An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome. Robert Gordon University, PhD thesis.

Type 2 diabetes and metabolic syndrome are the metabolic disorders which constitute a major public health problem in both developed and developing countries. Various studies have suggested the genetic susceptibility to the disorders. The main aim of... Read More about An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome..

Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences. (2018)
Thesis
HAIR, S.C. 2018. Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences. Robert Gordon University, PhD thesis.

Obesity has reached worldwide epidemic proportions and with this increased incidence of obesity, comes an increase in incidence of the comorbidities associated with obesity such as diabetes and cardiovascular disease (CVD). The underlying mechanisms... Read More about Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences..

Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies. (2018)
Thesis
KOPSIDA, M. 2018. Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies. Robert Gordon University, PhD thesis.

Breast cancer is the most commonly occurring cancer in women, with incidence rates approaching 1.38 million cases per year worldwide. Over the last few decades, there have been numerous attempts to develop, synthesise and advance into the clinic nove... Read More about Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies..

Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. (2017)
Journal Article
BARRON, G.A., GOUA, M., WAHLE, K.W.J. and BERMANO, G. 2017. Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. Oncology reports [online], 38(3), pages 1886-1894. Available from: https://doi.org/10.3892/or.2017.5803

The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matche... Read More about Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation..

Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. (2017)
Journal Article
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., SCOBBIE, L., MACIEL, P. and KONG THOO LIN, P. 2018. Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. Food chemistry [online], 239, pages 323-332. Available from: https://doi.org/10.1016/j.foodchem.2017.06.129

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. Analysis of ubiquitous secondary metabolites in RSP samples (two breeds, harvested in 2012/2014 respectively from North East of Scotland) and their eth... Read More about Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties..

Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. (2016)
Journal Article
KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], 14(41), pages 9780-9789. Available from: https://doi.org/10.1039/C6OB01850E

Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and cytotoxic activities. By modifyi... Read More about Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells..

Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts. (2016)
Presentation / Conference
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2016. Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts. Presented at 2016 Nutrition Society's Scottish section meeting: phytochemicals and health: new perspectives on plant based nutrition, 21-22 March 2016, Edinburgh, UK.

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. This study aimed to determine the polyphenol content, radical scavenging activity, ferric iron reducing antioxidant power and the oxygen-radical absorb... Read More about Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts..

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. (2015)
Journal Article
BARRON, G.A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and KONG THOO LIN, P. 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-biological interactions [online], 242, pages 307-315. Available from: https://doi.org/10.1016/j.cbi.2015.10.017

Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier work was extended to investiga... Read More about Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression..

Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. (2015)
Journal Article
KAPRAVELOU, G., MARTINEZ, R., ANDRADE, A.M., NEBOT, E., CAMILETTI-MOIRON, D., APARICIO, V.A., LOPEZ-JURADO, M., ARANDA, P., ARREBOLA, F., FERNANDEZ-SEGURA, E., BERMANO, G., GOUA, M., GALISTEO, M. and PORRES, J.M. 2015. Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. Applied physiology, nutrition and metabolism [online], 40(12), pages 1242-1252. Available from: https://doi.org/10.1139/apnm-2015-0141

Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the ben... Read More about Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats..

Can selenium supplementation modify oxidative stress in-vitro? (2015)
Journal Article
LEIGHTON, D., GOUA, M., DOLAN, E., BURGESS, K. and BERMANO, G. 2015. Can selenium supplementation modify oxidative stress in-vitro? A role for selenium supplementation in the prevention of cardiovascular disease. Journal of inflammation [online], 12(Supplement 1): abstracts from the 1st Annual meeting of the Scottish Society of Cytomics (SCC), 25 September 2014, Aberdeen, UK, article P7. Available from: https://doi.org/10.1186/1476-9255-12-S1-P7

Two thirds of the UK population are either overweight or obese (body mass index (BMI) 25-29.9 and >30 kg/m2 respectively) and are typically characterised by systemic oxidative stress (OS); deemed to play a key role in cardiovascular disease (CVD) dev... Read More about Can selenium supplementation modify oxidative stress in-vitro?.

The role of selenium supplementation in cardiovascular disease prevention: an in vitro study to identify the molecular mechanism(s). (2015)
Presentation / Conference
LEIGHTON, D., GOUA, M., DOLAN, E., BURGESS, K. and BERMANO, G. 2015. The role of selenium supplementation in cardiovascular disease prevention: an in vitro study to identify the molecular mechanism(s). Presented at the 2015 Nutrition Society Scottish section meeting: diet, gene regulation and metabolic disease, 25-26 March 2015, Aberdeen, UK.

Obesity is a worldwide epidemic, with two thirds of the UK population either overweight or obese (body mass index (BMI) 25–29·9 and >30 kg/m2 respectively). Obesity is characterised by systemic oxidative stress (OS), which itself results from chronic... Read More about The role of selenium supplementation in cardiovascular disease prevention: an in vitro study to identify the molecular mechanism(s)..

Modulation of angiogenesis by inflammatory markers and the role of matrix metalloproteinases in an endothelial cell/fibroblast co-culture system. (2014)
Journal Article
BARRON, G.A., BORDET, E., GOUA, M. and BERMANO. G. 2014. Modulation of angiogenesis by inflammatory markers and the role of matrix metalloproteinases in an endothelial cell/fibroblast co-culture system. Current angiogenesis [online], 3(3), pages 152-163. Available from: https://doi.org/10.2174/2211552803666141113211829

Increased levels of inflammatory markers such as tumour necrosis factor-α (TNFα) and interleukin- 6 (IL-6) have been associated with formation of new blood vessels, or angiogenesis, and linked to chronic inflammation in obesity. This study aimed to e... Read More about Modulation of angiogenesis by inflammatory markers and the role of matrix metalloproteinases in an endothelial cell/fibroblast co-culture system..

Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. (2014)
Journal Article
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2014. Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. Oncology letters [online], 8(1), pages 374-378. Available from: https://doi.org/10.3892/ol.2014.2085

Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher in obese postmenopausal women... Read More about Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling..

The molecular contribution of TNF-α in the link between obesity and breast cancer. (2010)
Journal Article
WEICHHAUS, M., BROOM, I. and BERMANO, G. 2011. The molecular contribution of TNF-α in the link between obesity and breast cancer. Oncology reports [online], 25(2), pages 477-483. Available from: https://doi.org/10.3892/or.2010.1099

Obesity is a growing worldwide medical problem, as it pre-disposes the affected hosts to a number of severe diseases, including postmenopausal breast cancer. Obesity development is characterised, amongst others, by aberrant secretion of adipokines. W... Read More about The molecular contribution of TNF-α in the link between obesity and breast cancer..

Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. (2010)
Thesis
BARRON, G. 2010. Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. Robert Gordon University, PhD thesis.

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaph... Read More about Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system..

Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. (2009)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K., HEYS, S. and BERMANO, G. 2009. Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. Presented at 17th European congress on obesity 2009 (ECO 2009), 6-9 May 2009, Amsterdam, Netherlands.

Obesity increases breast cancer incidence rates in postmenopausal women. Chronic high levels of insulin, present in the majority of obese and insulin resistant patients, may provide the growth promoting stimulus to explain this connection. In this wo... Read More about Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells..

Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. (2008)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. Presented at 6th annual World congress on insulin resistance syndrome 2008 (WCIRS 2008), 25-27 September 2008, Los Angeles, U.S.A.

Recent findings suggest a connection between obesity and breast cancer. Obesity is linked with higher incidences of insulin resistance as part of the metabolic syndrome, resulting in chronically elevated insulin plasma levels. We examined the effect... Read More about Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways..

Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. (2008)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. Presented at 16th European congress on obesity 2008 (ECO 2008), 14-17 May 2008, Geneva, Switzerland.

A growing number of clinical studies validate a relation of insulin resistance and breast cancer in obese patients. We hypothesised that high plasma insulin levels cause aberrant insulin signalling in breast epithelial cells which may be responsible... Read More about Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity..

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