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The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels. (2017)
Thesis
ADEYILEKA-TRACZ, B.A. 2017. The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels. Robert Gordon University, PhD thesis.

Humans are approximately 99% similar with inter-individual differences caused in part by single-nucleotide polymorphisms (SNPs), which poses a challenge for the effective treatment of disease. Bioinformatics resources can help to store and analyse ge... Read More about The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels..

Use of a three dimensional porcine retinal explant model to detect HIF1 alpha and targets for understanding diabetic retinopathy. (2017)
Presentation / Conference
IWUAGWU, B.U., CRUICKSHANK, S.F., ROWE, I. and KNOTT, R.M. 2017. Use of a three dimensional porcine retinal explant model to detect HIF1 alpha and targets for understanding diabetic retinopathy. Presented at the American Society for Biochemistry and Molecular Biology annual meeting 2017 (ASBMB'17), 22-26 April 2017, Chicago, USA.

Diabeticretinopathy (DR) is a major microvascular complication associated with diabetes mellitus and is a leading cause of blindness. Hypoxia and hyperglycemia are suggested to play crucial pathophysiological roles, but the exact mechanisms are compl... Read More about Use of a three dimensional porcine retinal explant model to detect HIF1 alpha and targets for understanding diabetic retinopathy..

Hypoxia-induced responses of porcine pulmonary veins. (2017)
Thesis
ARNOLD, A. 2017. Hypoxia-induced responses of porcine pulmonary veins. Robert Gordon University, PhD thesis.

The pulmonary vein (PV) constricts to hypoxia however little is known about the underlying mechanisms. Hypoxic PV constriction is proposed to recruit upstream capillary beds and optimise gas exchange in healthy humans and may play a role in high alti... Read More about Hypoxia-induced responses of porcine pulmonary veins..