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All Outputs (17)

The experiences of women with polycystic ovary syndrome on a very low-calorie diet. (2016)
Journal Article
LOVE, J.G., MCKENZIE, J.S., NIKOKAVOURA, E.A., BROOM, J., ROLLAND, C. and JOHNSTON, K.L. 2016. The experiences of women with polycystic ovary syndrome on a very low-calorie diet. International journal of women's health [online], 8, pages 299-310. Available from: https://doi.org/10.2147/IJWH.S100385

Polycystic ovary syndrome (PCOS) is variously reported to affect between 5% and 26% of reproductive age women in the UK and accounts for up to 75% of women attending fertility clinics due to anovulation. The first-line treatment option for overweight... Read More about The experiences of women with polycystic ovary syndrome on a very low-calorie diet..

Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. (2015)
Journal Article
NIKOKAVOURA, E.A., JOHNSTON, K.L., BROOM, J., WRIEDEN.W.L. and ROLLAND, C. 2015. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 8, pages 495-503. Available from: https://doi.org/10.2147/DMSO.S85134

Background: Polycystic ovary syndrome (PCOS) affects between 2% and 26% of reproductive-age women in the UK, and accounts for up to 75% of anovulatory infertility. The major symptoms include ovarian disruption, hyperandrogenism, insulin resistance, a... Read More about Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks..

Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. (2014)
Journal Article
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2014. Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. Oncology letters [online], 8(1), pages 374-378. Available from: https://doi.org/10.3892/ol.2014.2085

Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher in obese postmenopausal women... Read More about Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling..

Long-term weight loss maintenance and management following a VLCD: a 3-year outcome. (2013)
Journal Article
ROLLAND, C., JOHNSTON, K. L., LULA, S., MACDONALD, I. and BROOM, I. 2014. Long-term weight loss maintenance and management following a VLCD: a 3-year outcome. International journal of clinical practice [online], 68(3), pages 379-387. Available from: https://doi.org/10.1111/ijcp.12300

Background: Effective weight loss treatment is important as obesity has severe health and socioeconomic repercussions. Emerging evidence suggests that rapid initial weight loss results in better long-term weight loss maintenance. This remains controv... Read More about Long-term weight loss maintenance and management following a VLCD: a 3-year outcome..

Weight loss for individuals with type 2 diabetes following a very-low-calorie diet in a community-based setting with trained facilitators for 12 weeks. (2013)
Journal Article
ROLLAND, C., LULA, S., JENNER, C., DYSON, L., MACDONALD, I., JOHNSTON, K.L. and BROOM, I. 2013. Weight loss for individuals with type 2 diabetes following a very-low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Clinical obesity [online], 3(5), pages 150-157. Available from: https://doi.org/10.1111/cob.12029

Approximately 80% of people with type 2 diabetes mellitus (T2DM) are overweight or obese, and obesity compounds the cardiovascular risk of T2DM. The aim of this retrospective study was twofold: first to investigate whether a twelve-week, community-ba... Read More about Weight loss for individuals with type 2 diabetes following a very-low-calorie diet in a community-based setting with trained facilitators for 12 weeks..

Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet. (2012)
Journal Article
ROLLAND, C., HALLAM, C., LULA, S., WIGGINS, J., DYSON, L., VAN GAAL, L.F. and BROOM, I. 2013. Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet. Clinical and experimental medical sciences [online], 1(3), pages 97-109. Available from: http://m-hikari.com/cems/cems2013/cems1-4-2013/rollandCEMS1-4-2013.pdf

We aimed to determine whether British Asians of Indian or Pakistani descent differed in their baseline characteristics and in response to a twelve-week, very-low-calorie diet (VLCD). We then assessed whether or not a VLCD had a different effect on As... Read More about Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet..

Very-low-energy diets and morbidity: a systematic review of longer-term evidence. (2012)
Journal Article
MULHOLLAND, Y., NICOKAVOURA, E., BROOM, J. and ROLLAND, C. 2012. Very-low-energy diets and morbidity: a systematic review of longer-term evidence. British journal of nutrition [online], 108(5), pages 832-851. Available from: https://doi.org/10.1017/S0007114512001924

Evidence from the literature supports the safe use of very-low-energy diets (VLED) for up to 3 months in supervised conditions for patients who fail to meet a target weight loss using a standard low-fat, reduced-energy approach. There is, however, a... Read More about Very-low-energy diets and morbidity: a systematic review of longer-term evidence..

Low-carbohydrate diets, obesity and type 2 diabetes: a review. (2012)
Journal Article
GRYKA, A., BROOM, I. and ROLLAND, C. 2012. Low-carbohydrate diets, obesity and type 2 diabetes: a review. Agro food industry hi-tech [online], 23(Supplement 2), pages 12-14. Available from: https://www.teknoscienze.com/tks_article/low-carbohydrate-diets-obesity-and-type-2-diabetes-a-review/

This review examines the effects of low-carbohydrate, high-protein diets (LCHO) ( < 150g carbohydrate/day) on glycaemia and cardiovascular risk, appetite and satiety, liver and kidney function, energy expenditure, and bone metabolism. It also investi... Read More about Low-carbohydrate diets, obesity and type 2 diabetes: a review..

The effects of very-low calorie diets on HDL: a review. (2011)
Journal Article
ROLLAND, C. and BROOM, I. 2011. The effects of very-low calorie diets on HDL: a review. Cholesterol [online], 2011, article ID 306278. Available from: http://doi.org/10.1155/2011/306278

This paper investigates the effects of very-low-calorie diets (VLCDs) used in the treatment of obesity on high-density lipoprotein (HDL) levels. Although the studies varied widely in their intervention format, duration, and baseline HDL levels, it wo... Read More about The effects of very-low calorie diets on HDL: a review..

Optimizing acceptability and feasibility of an evidence-based behavioral intervention for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: an open-pilot intervention study in secondary care. (2011)
Journal Article
DOMBROWSKI, S.U., SNIEHOTTA, F.F., JOHNSTON, M., BROOM, I., KULKARNI, U., BROWN, J., MURRAY, L. and ARAƚJO-SOARES, V. 2012. Optimizing acceptability and feasibility of an evidence-based behavioral intervention for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: an open-pilot intervention study in secondary care. Patient education and counseling [online], 87(1), pages 108-119. Available from: https://doi.org/10.1016/j.pec.2011.08.003

Objective: To test and optimize the feasibility and acceptability of a physical activity (PA) and healthy eating behavior change intervention for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities. Methods:... Read More about Optimizing acceptability and feasibility of an evidence-based behavioral intervention for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: an open-pilot intervention study in secondary care..

Effect of weight loss on adipokine levels in obese patients. (2011)
Journal Article
ROLLAND, C., HESSION, M. and BROOM, I. 2011. Effect of weight loss on adipokine levels in obese patients. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 4, pages 315-323. Available from: https://doi.org/10.2147/DMSO.S22788

Adipose tissue functions as an endocrine organ by releasing adipokines, which have important roles in the regulation of inflammation and insulin sensitivity. Although there is evidence of improvements in the circulating levels of adipokines with weig... Read More about Effect of weight loss on adipokine levels in obese patients..

Global warming: is weight loss a solution? (2011)
Journal Article
GRYKA, A., BROOM, J., and ROLLAND, C. 2012. Global warming: is weight loss a solution? International journal of obesity [online], 36(3), pages 474-476. Available from: https://doi.org/10.1038/ijo.2011.151

The current climate change has been most likely caused by the increased greenhouse gas emissions. We have looked at the major greenhouse gas, carbon dioxide (CO2), and estimated the reduction in the CO2 emissions that would occur with the theoretical... Read More about Global warming: is weight loss a solution?.

Over-the-counter orlistat: early experiences, views and attitudes of community pharmacists in Great Britain. (2011)
Journal Article
WEIDMAN, A.E., CUNNINGHAM, S., GRAY, G., HANSFORD, D., MCLAY, J., BROOM, J. and STEWART, D. 2011. Over-the-counter orlistat: early experiences, views and attitudes of community pharmacists in Great Britain. International journal of clinical pharmacy [online], 33(4), pages 627-633. Available from: https://doi.org/10.1007/s11096-011-9516-z

Objectives of the study To describe community pharmacists early experiences, views and attitudes with over-the-counter orlistat, 9 months post legal re-classification from November 2009 to January 2010. Setting 13,200 (81%) randomly selected register... Read More about Over-the-counter orlistat: early experiences, views and attitudes of community pharmacists in Great Britain..

Weight loss and cholesterol lowering in the elderly. (2010)
Journal Article
ROLLAND, C. and BROOM, I. 2010. Weight loss and cholesterol lowering in the elderly. GM2: peer-reviewed medicine for the 50+ patient [online], 40(1), pages 27-36. Available from: https://www.gmjournal.co.uk/weight-loss-and-cholesterol-lowering-in-the-elderly

Weight loss and cholesterol lowering in the elderly remains a controversial issue. Obesity is considered to be problematic as a result of associated dyslipidemia, cardiovascular disease and mortality. Diet, exercise, medication and laparoscopic gastr... Read More about Weight loss and cholesterol lowering in the elderly..

Engaging patients, clinicians and health funders in weight management: the Counterweight Programme. (2008)
Journal Article
MCQUIGG, M., BROWN, J.E., BROOM, J.I., LAWS, R.A., RECKLESS, J.P.D., NOBLE, P.A., KUMAR, S., MCCOMBIE, E.L., LEAN, M.E.J., LYONS, G.F., MONGIA, S., FROST, G.S., QUINN, M.F., BARTH, J.H., HAYNES, S.M., FINER, N., HASLAM, D.W., ROSS, H.M., HOLE, D.J. and RADZIWONIK, S. 2008. Engaging patients, clinicians and health funders in weight management: the Counterweight Programme. Family practice [online], 25(Supplement 1), pages i79-i86. Available from: https://doi.org/10.1093/fampra/cmn081

Background. The Counterweight Programme provides an evidence based and effective approach for weight management in routine primary care. Uptake of the programme has been variable for practices and patients. Aim. To explore key barriers and facilitato... Read More about Engaging patients, clinicians and health funders in weight management: the Counterweight Programme..

Thinking around abdominal obesity and cardiovascular risk. (2006)
Journal Article
BROOM, I. 2006. Thinking around abdominal obesity and cardiovascular risk. British journal of diabetes and vascular disease, 6(2), pages 58-61.

Obesity, particularly intra-abdominal (visceral) obesity, is a leading cause of cardiovascular disease (CVD), insulin resistance, type 2 diabetes, dyslipidaemia, inflammation and thrombosis. A useful indicator for visceral fat is waist circumference,... Read More about Thinking around abdominal obesity and cardiovascular risk..

Changes in body composition after thermal injury in the rat. (1979)
Journal Article
AL SHAMMA, G.A., GOLL. C.C., BAIRD, T.B., BROOM, J., NICHOLAS, G.A. and RICHARDS, J.R. 1979. Changes in body composition after thermal injury in the rat. British journal of nutrition [online], 42(3), pages 367-375. Available at: https://doi.org/10.1079/BJN19790126

1. The effects on body composition, measured by direct techniques, of a controlled 25% body-surfacearea thermal injury have been studied in two groups of forty male Wistar rats. 2. The extent of weight loss in the animals was directly related to thei... Read More about Changes in body composition after thermal injury in the rat..