All Outputs (41)

Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. (2024)
Journal Article
POHL, F., LINDSAY-MCGEE, V., KONG THOO LIN, P., MACIEL, P. and TEIXEIRA-CASTRO, A. 2024. Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. microPublication biology [online], 2024(2), 001086. Available from: https://doi.org/10.17912/micropub.biology.001086

Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer's disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar At... Read More about Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model..

UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. (2023)
Journal Article
POHL, F., GERMANN, A.L., MAO, J., HOU, S., BAKARE, B., KONG THOO LIN, P., YATES, K., NONET, M.L., AKK, G., KORNFELD, K. and HELD, J.M. 2023. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. Science advances [online], 9(44). Available from: https://doi.org/10.1126/sciadv.adh2584

The γ-aminobutyric acid–mediated (GABAergic) system participates in many aspects of organismal physiology and disease, including proteostasis, neuronal dysfunction and life-span extension. Many of these phenotypes are also regulated by reactive oxyge... Read More about UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously..

Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. (2023)
Journal Article
BLAIKIE, L., WELGAMAGE DON, A., FRANZEN, X., FERNANDEZ, C., FAISAL, N. and KONG THOO LIN, P. [2023]. Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. Waste and biomass valorization [online], Online First. Available from: https://doi.org/10.1007/s12649-023-02292-4

Waste by-products such as pot ale are abundantly produced during the whisky distillation process and are conventionally used as livestock feed, however a significant proportion continues to require land and sea disposal. Here, the novel potential of... Read More about Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential..

DNA profiling of single sperm cells after whole genome amplification. (2021)
Journal Article
THEUNISSEN, G.M.G., GIBB, A., KONG THOO LIN, P., ROLF, B., FORAT, S. and JÄGER, R. 2021. DNA profiling of single sperm cells after whole genome amplification. Forensic science international: reports [online], 4, article 100240. Available from: https://doi.org/10.1016/j.fsir.2021.100240

Intimate swabs taken for examination in sexual assault cases typically yield mixtures of sperm and epithelial cell types. While powerful, differential extraction protocols to overcome such cell type mixtures by separate lysis of epithelial cells and... Read More about DNA profiling of single sperm cells after whole genome amplification..

Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. (2020)
Journal Article
POHL, F., GOUA, M., YATES, K., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2021. Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. Journal of food biochemistry [online], 45(2), article e13592. Available from: https://doi.org/10.1111/jfbc.13592

With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study. For the first time, we highlight the neuroprotective proper... Read More about Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells..

Electroanalytical determination of gallic acid in red and white wine samples using cobalt oxide nanoparticles-modified carbon-paste electrodes. (2020)
Journal Article
CHIKERE, C.O., HOBBEN, E., FAISAL, N.H., KONG THOO LIN, P. and FERNANDEZ, C. 2021. Electroanalytical determination of gallic acid in red and white wine samples using cobalt oxide nanoparticles-modified carbon-paste electrodes. Microchemical journal [online], 160(part B), article ID 105668. Available from: https://doi.org/10.1016/j.microc.2020.105668

Beverages like wines, have exhibited a high level of antioxidant capacity, specifically from compounds like Gallic acid (GA) and their derivatives. GA has shown great importance in the food industry and pharmaceutical industry as a food additive, ant... Read More about Electroanalytical determination of gallic acid in red and white wine samples using cobalt oxide nanoparticles-modified carbon-paste electrodes..

Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease. (2020)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2020. Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer's disease. Bioorganic and medical chemistry letters [online], 30(21), article ID 127505. Available from: https://doi.org/10.1016/j.bmcl.2020.127505

A number of novel naphthalimido and phthalimido vanillin derivatives were synthesised, and evaluated as antioxidants and cholinesterase inhibitors in vitro. Antioxidant activity was assessed using DPPH, FRAP, and ORAC assays. All compounds demonstrat... Read More about Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease..

Interaction between amorphous zirconia nanoparticles and graphite: electrochemical applications for gallic acid sensing using carbon paste electrodes in wine. (2020)
Journal Article
CHIKERE, C.O., FAISAL, N.H., KONG THOO LIN, P. and FERNANDEZ, C. 2020. Interaction between amorphous zirconia nanoparticles and graphite: electrochemical applications for gallic acid sensing using carbon paste electrodes in wine. Nanomaterials [online], 10(3), article ID 537. Available from: https://doi.org/10.3390/nano10030537

Amorphous zirconium oxide nanoparticles (ZrO2) have been used for the first time, to modify carbon paste electrode (CPE) and used as a sensor for the electrochemical determination of gallic acid (GA). The voltammetric results of the ZrO2 nanoparticle... Read More about Interaction between amorphous zirconia nanoparticles and graphite: electrochemical applications for gallic acid sensing using carbon paste electrodes in wine..

GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. (2019)
Journal Article
POHL, F., TEIXEIRA-CASTRO, A., COSTA, M.D., LINDSAY, V., FIÚZA-FERNANDES, J., GOUA, M., BERMANO, G., RUSSELL, W., MACIEL, P. and KONG THOO LIN, P. 2019. GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. Frontiers in neuroscience [online], 13, article ID 1091. Available from: https://doi.org/10.3389/fnins.2019.01091

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson’s disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as impor... Read More about GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation..

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. (2019)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2019. Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. MedChemComm [online], 10(12), pages 2052-2072. Available from: https://doi.org/10.1039/c9md00337a

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. The number of people suffering from this debilitating disorder is rising at an unprecedented rate, with a subsequent surge in healthcare c... Read More about Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands..

The synergistic effect between graphene oxide nanocolloids and silicon dioxide nanoparticles for gallic acid sensing. (2019)
Journal Article
CHIKERE, C.O., FAISAL, N.H., KONG THOO LIN, P. and FERNANDEZ, C. 2019. The synergistic effect between graphene oxide nanocolloids and silicon dioxide nanoparticles for gallic acid sensing. Journal of solid state electrochemistry [online], 23(6), pages 1795-1809. Available from: https://doi.org/10.1007/s10008-019-04267-9

For the first time, the synergistic effect of graphene oxide nanocolloids (nano-GO) and silicon dioxide (silica) nanoparticles (SiO2-nanoparicles) has been used to modify a glassy carbon electrode (GCE) for the determination of gallic acid (GA). The... Read More about The synergistic effect between graphene oxide nanocolloids and silicon dioxide nanoparticles for gallic acid sensing..

Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease. (2019)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I.L. and KONG THOO LIN, P. 2019. Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer’s disease. MedChemComm [online], 10(5), pages 764-777. Available from: https://doi.org/10.1039/c9md00048h

Alzheimer’s Disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a “multi-target-directed ligands” (MTDLs) approach for the treatment of this illness ha... Read More about Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease..

The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. (2018)
Journal Article
POHL, F. and KONG THOO LIN, P. 2018. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. Molecules [online], 23(12), article ID 3283. Available from: https://doi.org/10.3390/molecules23123283

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Huntington's disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase o... Read More about The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials..

Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties. (2018)
Journal Article
YATES, K., POHL, F., BUSCH, M., MOZER, A., WATTERS, L., SHIRYAEV, A. and KONG THOO LIN, P. 2019. Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties. Food chemistry [online], 276, pages 768-775. Available from: https://doi.org/10.1016/j.foodchem.2018.10.045

Sinapine is the main secondary metabolite present in rapeseed pomace (RSP) with its concentration being dependent on rapeseed processing, growing conditions, extraction parameters and the country of origin. Here we report, the concentration of sinapi... Read More about Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties..

A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines. (2018)
Journal Article
ALSURAIFI, A., KONG THOO LIN, P., CURTIS, A., LAMPROU, D.A. and HOSKINS, C. 2018. A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines. Pharmaceuticals [online], 11(4), article ID 91. Available from: https://doi.org/10.3390/ph11040091

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery system... Read More about A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines..

Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. (2018)
Journal Article
BESTWICK, C., MILNE, L., DANCE, A.-M., COCHENNEC, G., CRUICKSHANK, G., ALLAIN, E., CONSTABLE, L., DUTHIE, S.J. and KONG THOO LIN, P. 2018. Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. Toxicology in vitro [online], 52, pages 342-350. Available from: https://doi.org/10.1016/j.tiv.2018.06.023

Bisnaphthalimides are DNA intercalators of potential use as chemotherapeutics but for which the range of mechanism of action is only gradually being elucidated. Using human promyelocytic HL-60 cells, we extend characterization of the cytotoxicity of... Read More about Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells..

Inhibitors of trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. (2018)
Journal Article
GASPAR, L., CORON, R.P., KONG THOO LIN, P., COSTA, D.M., PERES-CABEZAS, B., TAVARES, J., ROURA-FERRER, M., RAMOS, I., RONIN, C., MAJOR, L.L., CIESIELSKI, F., PEMBERTON, I.K., MACDOUGALL, J., CIAPETTI, P., SMITH, T.K. and CORDEIRO-DA-SILVA, A. 2018. Inhibitors of trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. PLoS neglected tropical diseases [online], 12(1), article number e0006180. Available from: https://doi.org/10.1371/journal.pntd.0006180

Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-rel... Read More about Inhibitors of trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease..

Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties. (2017)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I. and KONG THOO LIN, P. 2017. Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties. European journal of medicinal chemistry [online], 143, pages 745-754. Available from: https://doi.org/10.1016/j.ejmech.2017.11.072

Antioxidants have been the subject of intense research interest mainly due to their beneficial properties associated with human health and wellbeing. Phenolic molecules, such as naturally occurring Resveratrol and Vanillin, are well known for their a... Read More about Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties..

Thermally triggered theranostics for pancreatic cancer therapy. (2017)
Journal Article
MALEKIGORJI, M., ALFAHAD, M., KONG THOO LIN, P., JONES, S., CURTIS, A. and HOSKINS, C. 2017. Thermally triggered theranostics for pancreatic cancer therapy. Nanoscale [online], 9(34), pages 12735-12745. Available from: https://doi.org/10.1039/c7nr02751f

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation re... Read More about Thermally triggered theranostics for pancreatic cancer therapy..

Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. (2017)
Journal Article
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., SCOBBIE, L., MACIEL, P. and KONG THOO LIN, P. 2018. Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. Food chemistry [online], 239, pages 323-332. Available from: https://doi.org/10.1016/j.foodchem.2017.06.129

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. Analysis of ubiquitous secondary metabolites in RSP samples (two breeds, harvested in 2012/2014 respectively from North East of Scotland) and their eth... Read More about Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties..