All Outputs (833)

Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors. (2016)
Journal Article
LANCE, E., DESPRAT, J., HOLBECH, B.F., GERARD, C., BORMANS, M., LAWTON, L.A., EDWARDS, C. and WIEGAND, C. 2016. Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors. Aquatic toxicology [online], 177, pages 116-124. Available from: https://doi.org/10.1016/j.aquatox.2016.05.024

Freshwater gastropods are increasingly exposed to multiple stressors in the field such as the herbicide glyphosate in Roundup formulations and cyanobacterial blooms either producing or not producing microcystins (MCs), potentially leading to interact... Read More about Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors..

A case study investigation into the use of multi-compartment compliance aids in older people resident in very sheltered housing. (2016)
Journal Article
MACLURE, K., MACLEOD, J., FORBES-MCKAY, K., PAUDYAL, V., CUNNINGHAM, S., STRATH, A., LYNCH, R. and STEWART, D. 2016. A case study investigation into the use of multi-compartment compliance aids in older people resident in very sheltered housing. Patient: patient-centered outcomes research [online] 9(6), pages 583-590. Available from: https://doi.org/10.1007/s40271-016-0178-8

Background: Multi-compartment compliance aids (MCAs) are repackaging systems for solid dosage form medicines, heralded by some as a solution to non-adherence but with little evidence of benefit. Objective: The aim was to use a theoretical approach to... Read More about A case study investigation into the use of multi-compartment compliance aids in older people resident in very sheltered housing..

Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning. (2016)
Journal Article
DELGADO-BAQUERIZO, M., GIARAMIDA, L., REICH, P.B., KHACHANE, A.N., HAMONTS, K., EDWARDS, C., LAWTON, L.A. and SINGH, B.K. 2016. Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning. Journal of ecology [online], 104(4), pages 936-946. Available from: https://doi.org/10.1111/1365-2745.12585

1. Biodiversity is declining worldwide with detrimental effects on ecosystems. However, we lack a quantitative understanding of the shape of the relationship between microbial biodiversity and ecosystem function (BEF). This limits our understanding o... Read More about Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning..

Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states. (2016)
Journal Article
MOLINA-LOPEZ, J., PLANELLS DEL POZO, E., FLOREA, D.L., FERNANDEZ, C., OSSO, B.Q., ZALEWSKA, M., KRIZKOVA, S., HEGER, Z., KIZEK, R. and ADAM, V. 2016. Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states. International journal of electrochemical science [online], 11(6), pages 4470-4496. Available from: https://doi.org/10.20964/2016.06.38

Zinc, an essential element playing crucial roles in numerous physiological, but also pathological processes, is still one of the most studied elements. The main importance of this metal is especially based on the structural role of zinc ions in many... Read More about Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states..

Terminalia ivorensis A. Chev. ethanolic stem bark extract protects against gentamicin-induced renal and hepatic damage in rats. (2016)
Journal Article
ANSAH, C., MOOMIN, A. and BOADU, K.M. 2016. Terminalia ivorensis A. Chev. ethanolic stem bark extract protects against gentamicin-induced renal and hepatic damage in rats. Journal of applied pharmaceutical science [online], 6(4), pages 175-182. Available from: https://doi.org/10.7324/japs.2016.60425

The aim of present study was to investigate the possible protective effects of an ethanolic stem bark extract of Terminalia ivorensis on gentamicin – induced nephrotoxicity and hepatotoxicity in male Sprague-Dawley rats. Groups of animals received ei... Read More about Terminalia ivorensis A. Chev. ethanolic stem bark extract protects against gentamicin-induced renal and hepatic damage in rats..

Exploring behavioural determinants relating to health professional reporting of medication errors: a qualitative study using the theoretical domains framework. (2016)
Journal Article
ALQUBAISI, M., TONNA, A., STRATH, A. and STEWART, D. 2016. Exploring behavioural determinants relating to health professional reporting of medication errors: a qualitative study using the theoretical domains framework. European journal of clinical pharmacology [online], 72(7), pages 887-895. Available from: https://doi.org/10.1007/s00228-016-2054-9

Purpose: Effective and efficient medication reporting processes are essential in promoting patient safety. Few qualitative studies have explored reporting of medication errors by health professionals, and none have made reference to behavioural theor... Read More about Exploring behavioural determinants relating to health professional reporting of medication errors: a qualitative study using the theoretical domains framework..

A modified Delphi study of structures and processes related to medicines management for elderly hospitalised patients in the United Arab Emirates. (2016)
Journal Article
AL SHEMEILI, S., KLEIN, S., STRATH, A., FARES, S. and STEWART, D. 2016. A modified Delphi study of structures and processes related to medicines management for elderly hospitalised patients in the United Arab Emirates. Journal of evaluation in clinical practice [online], 22(5), pages 781-791. Available from: https://doi.org/10.1111/jep.12542

Rationale and aim: The structures and processes around the management of medicines for elderly, hospitalized patients are ill defined. This study aimed to determine consensus related to strategic and operational approaches in the United Arab Emirates... Read More about A modified Delphi study of structures and processes related to medicines management for elderly hospitalised patients in the United Arab Emirates..

Reviewing the literature, how systematic is systematic? (2016)
Journal Article
MACLURE, K., PAUDYAL, V. and STEWART, D. 2016. Reviewing the literature, how systematic is systematic? International journal of clinical pharmacy [online], 38(3), pages 685-694. Available from: https://doi.org/10.1007/s11096-016-0288-3

Introduction Professor Archibald Cochrane, after whom the Cochrane Collaboration is named, was influential in promoting evidence-based clinical practice. He called for 'relevant, valid research' to underpin all aspects of healthcare. Systematic revie... Read More about Reviewing the literature, how systematic is systematic?.

Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei. (2016)
Journal Article
GRACA, N.A.G., GASPAR, L, COSTA, D.M., LOUREIRO, I., KONG THOO LIN, P., RAMOS, I., ROURA, M., PRUVOST, A., PEMBERTON, I.K., LOUKIL, H., MACDOUGALL, J., TAVARES, J. and CORDEIRO-DA-SILVA, A. 2016. Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei. Antimicrobial agents and chemotherapy [online], 60(4), pages 2532-2536. Available from: https://doi.org/10.1128/AAC.02490-15

Current treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives against Trypanosoma brucei. BNIPDiaminobut... Read More about Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei..

New framework to diagnose the direct disposal of prescribed drugs in wastewater: a case study of the antidepressant fluoxetine. (2016)
Journal Article
PETRIE, B., YOUDAN, J., BARDEN, R., KASPRZYK-HORDERN, B. 2016. New framework to diagnose the direct disposal of prescribed drugs in wastewater: a case study of the antidepressant fluoxetine. Environmental science and technology [online], 50(7), pages 3781-3789. Available from: https://doi.org/10.1021/acs.est.6b00291

Intentional or accidental release (direct disposal) of high loads of unused pharmaceuticals into wastewater can go unnoticed. Here, direct disposal of a pharmaceutical drug via the sewer network was identified for the first time using wastewater anal... Read More about New framework to diagnose the direct disposal of prescribed drugs in wastewater: a case study of the antidepressant fluoxetine..

New insights into the yin and yang of the endocannabinoid system in health and disease. (2016)
Journal Article
WAINWRIGHT, C. 2016. New insights into the yin and yang of the endocannabinoid system in health and disease. British journal of pharmacology [online], 173(7), pages 1113-1115. Available from: https://doi.org/10.1111/bph.13451

This article is part of a themed section on Endocannabionoids, of which the author is guest editor. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.7/issuetoc.

A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction. (2016)
Journal Article
FAASSEN, E.J., ANTONIOU, M.G., BEEKMAN-LUKASSEN, W., BLAHOVA, L., CHERNOVA, E., CHRISTOPHORIDIS, C., COMBES, A., EDWARDS, C., FASTNER, J., HARMSEN, J., HISKIA, A., ILAG, L.L., KALOUDIS, T., LOPICIC, S., LURLING, M., MAZUR-MARZEC, H., MERILUOTO, J., POROJAN, C., VINER-MOZZINI, Y. and ZGUNA, N. 2016. A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction. Marine drugs [online], 14(3), article 45. Available from: https://doi.org/10.3390/md14030045

Exposure to β-Ν-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. Analytical chemistry plays a crucial role in determining human BMAA exposure and the associat... Read More about A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction..

Asking the right question: a comparison of two approaches to gathering data on 'herbals' use in survey based studies. (2016)
Journal Article
MCLAY, J.S., PALLIVALAPPILA, A.R., SHETTY, A., PANDE, B., AL HAIL, M. and STEWART, D. 2016. Asking the right question: a comparison of two approaches to gathering data on 'herbals' use in survey based studies. PLoS ONE [online], 11(2), e0150140. Available from: https://doi.org/10.1371/journal.pone.0150140

Background: Over the last decade academic interest in the prevalence and nature of herbal medicines use by pregnant women has increased significantly. Such data are usually collected by means of an administered questionnaire survey, however a key met... Read More about Asking the right question: a comparison of two approaches to gathering data on 'herbals' use in survey based studies..

Outpatient parenteral antibiotic therapy (OPAT): a qualitative study of patient perspectives in those choosing not to self-administer. (2016)
Journal Article
TONNA, A., PAUDYAL, V., FORBES-MCKAY, K., FALCONER, S., ANTHONY, G., TONNA, I., LAING, R., MACKENZIE, A., MACARTNEY, G. and STEWART, D. 2016. Outpatient parenteral antibiotic therapy (OPAT): a qualitative study of patient perspectives in those choosing not to self-administer. European journal of hospital pharmacy [online], 23(Supplement 1), article A8. Available from: https://doi.org/10.1136/ejhpharm-2016-000875.18

OPAT is a well established treatment for administration of intravenous (IV) antibiotics, and models of administration include home self-administration. Despite this offering advantages, statistics indicate that less patients in the research centre ho... Read More about Outpatient parenteral antibiotic therapy (OPAT): a qualitative study of patient perspectives in those choosing not to self-administer..

Nicorandil, gastrointestinal adverse drug reactions and ulcerations: a systematic review. (2016)
Journal Article
PISANO, U., DEOSARAN, J., LESLIE, S.J., RUSHWORTH, G.F., STEWART, D., FORD, I. and WATSON, A.J.M. 2016. Nicorandil, gastrointestinal adverse drug reactions and ulcerations: a systematic review. Advances in therapy [online], 33(3), pages 320-344. Available from: https://doi.org/10.1007/s12325-016-0294-9

Nicorandil is a popular anti-anginal drug in Europe and Japan. Apart from some common adverse drug reactions (ADR), its safety is satisfactory. Several reports have suggested a link between nicorandil, gastrointestinal (GI) ulceration and fistulas. T... Read More about Nicorandil, gastrointestinal adverse drug reactions and ulcerations: a systematic review..

A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar. (2016)
Journal Article
ALSAAD, D., ELSALEM, S., ABDULROUF, P., THOMAS, B., ALSAAD, T., AHMAD, A. and ALHAIL, M. 2016. A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar. Therapeutics and clinical risk management [online], 12, pages 155-160. Available from: https://doi.org/10.2147/TCRM.S96298

Background: Breastfeeding is considered as gold standard for infant nutrition and should be interrupted only when a compelling indication exists. Certain medical conditions such as abortion, stillbirth, HIV infection, or infant galactosemia and certa... Read More about A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar..

Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva. (2016)
Journal Article
BARTLETT, C.-A., TAYLOR, S., FERNANDEZ, C., WANKLYN, C., BURTON, D., ENSTON, E., RANICZKOWSKA, A., BLACK, M. and MURPHY, L. 2016. Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva. Chemistry central journal [online], 10, article number 3. Available from: https://doi.org/10.1186/s13065-016-0147-2

Background: Methamphetamine has an adverse effect on the ability to drive safely. Police need to quickly screen potentially impaired drivers therefore a rapid disposable test for methamphetamine is highly desirable. This is the first proof-of-concept... Read More about Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva..

Differential pulse voltammetric determination of albendazole and mebendazole in pharmaceutical formulations based on modified sonogel carbon paste electrodes with perovskite-type LaFeO3 nanoparticles. (2016)
Journal Article
DE MACEDO, I.Y.L., GARCIA, L.F., DE SOUZA, A.R., DA SILVA, A.M.L., FERNANDEZ, C., SANTOS, M.D.G., MAGALHÃES, R.S., TORRES, I.M.S. and GIL, E.S. 2016. Differential pulse voltammetric determination of albendazole and mebendazole in pharmaceutical formulations based on modified sonogel carbon paste electrodes with perovskite-type LaFeO3 nanoparticles. Journal of the Electrochemical Society [online], 163(8), pages B428-B434. Available from: https://doi.org/10.1149/2.0661608jes

Benzimidazoles, such as albendazole (AB) and mebendazole (MB), are common anthelmintic agents, widely used throughout the world to combat parasitic diseases. The electroanalytical sensing of AB and MB based on Perovskite-Type LaFeO3 nanoparticles mod... Read More about Differential pulse voltammetric determination of albendazole and mebendazole in pharmaceutical formulations based on modified sonogel carbon paste electrodes with perovskite-type LaFeO3 nanoparticles..

Exploiting the antiparasitic activity of naphthalimides derivatives. (2016)
Journal Article
CRISTO, G., GASPAR, L., NORO, J., BAPTISTA, C., KONG THOO LIN, P., ALVES, M.J. and CORDEIRO-DA-SILVA, A. 2016. Exploiting the antiparasitic activity of naphthalimides derivatives. International journal of chemistry and pharmaceutical sciences [online], 4(1), pages 19-23. Available from: http://www.pharmaresearchlibrary.com/wp-content/uploads/2016/06/IJCPS2793.pdf

A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmania infantum, Trypanosomabrucei and Trypanosoma cruzi. Additionally, toxicity was determined by growth inhibition... Read More about Exploiting the antiparasitic activity of naphthalimides derivatives..

Correlation among physical and electrochemical behaviour of nanostructured electrolytic manganese dioxide from leach liquor and synthetic for aqueous asymmetric capacitor. (2016)
Journal Article
SUNDARAM, M.M., BISWAL, A., MITCHELL, D., JONES, R. and FERNANDEZ, C. 2016. Correlation among physical and electrochemical behaviour of nanostructured electrolytic manganese dioxide from leach liquor and synthetic for aqueous asymmetric capacitor. Physical chemistry chemical physics [online], 18(6), pp. 4711-4720. Available from: https://doi.org/10.1039/C5CP07141K

An attempt has been made to correlate the differences in structural parameters, surface areas, morphology etc. with the electrochemical capacitive behaviour of the EMDs. The nanostructured electrolytic manganese dioxides (EMD) have been synthesized t... Read More about Correlation among physical and electrochemical behaviour of nanostructured electrolytic manganese dioxide from leach liquor and synthetic for aqueous asymmetric capacitor..