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Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. (2016)
Journal Article
MCKENZIE, B., KAY, G., MATTHEWS, K.H., KNOTT, R. and CAIRNS, D. 2016. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. International journal of pharmaceutics [online], 515(1-2), pages 575-582. Available from: https://doi.org/10.1016/j.ijpharm.2016.10.044

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of... Read More about Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis..

The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop® and ImageJ. (2015)
Journal Article
MCKENZIE, B., KAY, G., MATTHEWS, K.H., KNOTT, R.M. and CAIRNS, D. 2015. The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop® and ImageJ. International journal of pharmaceutics [online], 490(1-2), pages 1-8. Available from: https://doi.org/10.1016/j.ijpharm.2015.05.023

A modified hen’s egg chorioallantoic membrane (HET-CAM) test has been developed, combining ImageJ analysis with Adobe® Photoshop®. The irritation potential of an ophthalmic medicine can be quantified using this method, by monitoring damage to blood v... Read More about The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop® and ImageJ..

Three salts from the reactions of cysteamine and cystamine with L-(+)-tartaric acid. (2013)
Journal Article
BENYLLES, A., CAIRNS, D., COX, P.J. and KAY, G. 2013. Three salts from the reactions of cysteamine and cystamine with L-(+)-tartaric acid. Acta crystallographica section C: crystal structure communications [online], 69(6), pages 658-664. Available at: https://doi.org/10.1107/S0108270113012377

Reaction between cysteamine (systematic name: 2-aminoethanethiol, C 2H7NS) and l-(+)-tartaric acid [systematic name: (2R,3R)-2,3-dihydroxybutanedioic acid, C4H6O6] results in a mixture of cysteamine tartrate(1-) monohydrate, C2H 8NS+·C4H5O6-·H2O, (I)... Read More about Three salts from the reactions of cysteamine and cystamine with L-(+)-tartaric acid..

Suppository formulations as a potential treatment for nephropathic cystinosis. (2012)
Journal Article
BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-3738. Available from: https://doi.org/10.1002/jps.23246

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste... Read More about Suppository formulations as a potential treatment for nephropathic cystinosis..