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Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis. (2022)
Journal Article
HECTOR, E., CAIRNS, D. and WALL, G.W. 2022. Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis. Orphanet journal of rare diseases [online], 17, article 231. Available from: https://doi.org/10.1186/s13023-022-02367-w

Background: Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome. Loss of... Read More about Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis..

Time above the MIC of piperacillin-tazobactam as a predictor of outcome in pseudomonas aeruginosa bacteraemia. (2020)
Journal Article
TANNOUS, E., LIPMAN, S., TONNA, A., HECTOR, E., HUSSEIN, Z., STEIN, M., and REISFELD, S. 2020. Time above the minimum inhibitory concentration of piperacillin/tazobactam as a predictor of outcome in Pseudomonas aeruginosa bacteraemia. Antimicrobial agents and chemotherapy [online], 64(8), article ID e02571-19. Available from: https://doi.org/10.1128/AAC.02571-19

All rights reserved. Pseudomonas aeruginosa bacteremia is an infection associated with a high mortality rate. Piperacillin-tazobactam is a β-lactam-β-lactamase inhibitor combination that is frequently used for the management of Pseudomonas aeruginosa... Read More about Time above the MIC of piperacillin-tazobactam as a predictor of outcome in pseudomonas aeruginosa bacteraemia..

GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. (2014)
Journal Article
WALSH, S.K., HECTOR, E.E., ANDREASSON, A.-C., JONSSON-RYLANDER, A.-C. and WAINWRIGHT, C. L. 2014. GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. PLoS ONE [online], 9(10), article number e108999. Available from: https://doi.org/10.1371/journal.pone.0108999

G protein coupled receptor 55 (GPR55) is expressed throughout the body and, although its exact physiological function is unknown, studies have suggested that it has a role in the cardiovascular system. In particular, GPR55 has been proposed as mediat... Read More about GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses..