Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression.

Barron, Gemma A.; Goua, Marie; Kuraoka, Isao; Bermano, Giovanna; Iwai, Shigenori; Kong Thoo Lin, Paul

doi:10.1016/j.cbi.2015.10.017

The role of rs713041 glutathione peroxidase 4 (GPX4) single nucleotide polymorphism on disease susceptibility in humans: a systematic review and meta-analysis. (2022)
Journal Article
BARBOSA, P., ABO EL-MAGD, N.F., HESKETH, J. and BERMANO, G. 2022. The role of rs713041 glutathione peroxidase 4 (GPX4) single nucleotide polymorphism on disease susceptibility in humans: a systematic review and meta-analysis. International journal of molecular sciences [online], 23(24), article 15762. Available from: https://doi.org/10.3390/ijms232415762

The single-nucleotide polymorphism (SNP) rs713041, located in the regulatory region, is required to incorporate selenium into the selenoprotein glutathione peroxidase 4 (GPX4) and has been found to have functional consequences. This systematic review... Read More about The role of rs713041 glutathione peroxidase 4 (GPX4) single nucleotide polymorphism on disease susceptibility in humans: a systematic review and meta-analysis..

Selenium, as selenite, prevents adipogenesis by modulating selenoproteins gene expression and oxidative stress-related genes. (2021)
Journal Article
ABO EL-MAGD, N.F., BARBOSA, P.O., NICK, J., COVALERO, V., GRIGNETTI, G. and BERMANO, G. 2022. Selenium, as selenite, prevents adipogenesis by modulating selenoproteins gene expression and oxidative stress-related genes. Nutrition [online], 93, article 111424. Available from: https://doi.org/10.1016/j.nut.2021.111424

The aim of this study was to assess the effect of the micronutrient selenium, as inorganic selenite, on adipocytes differentiation, and to identify underlying molecular mechanisms to advance the understanding of basic cellular mechanisms associated w... Read More about Selenium, as selenite, prevents adipogenesis by modulating selenoproteins gene expression and oxidative stress-related genes..

An innovative protocol to select the best growth phase for astaxanthin biosynthesis in H. pluvialis. (2021)
Journal Article
RADICE, R.P., FIORENTINO, R., DE LUCA, M., LIMONGI, A.R., VIVIANO, E., BERMANO, G. and MARTELLI, G. 2021. An innovative protocol to select the best growth phase for astaxanthin biosynthesis in H. pluvialis. Biotechnology reports [online], 31, article e00655. Available from: https://doi.org/10.1016/j.btre.2021.e00655

H. pluvialis is a green unicellular microalgae and it is the first producer of natural astaxanthin in the world if subjected to stress conditions such as high light, high salinity and nutrient starvation. Astaxanthin is a powerful antioxidant used in... Read More about An innovative protocol to select the best growth phase for astaxanthin biosynthesis in H. pluvialis..

Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis. (2021)
Journal Article
RADICE, R.P., LIMONGI, A.R., VIVIANO, E., PADULA, M.C., MARTELLI, G. and BERMANO, G. 2021. Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis. Free radical biology and medicine [online], 171, pages 156-168. Available from: https://doi.org/10.1016/j.freeradbiomed.2021.05.008

Background and aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antiox... Read More about Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis..

Açaí (Euterpe oleracea martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes’ gene expression in offspring. (2021)
Journal Article
BARBOSA, P.O., SOUZA, M.O., SILVA, M.P.S., SANTOS, G.T., SILVA, M.E., BERMANO, G. and FREITAS, R.N. 2021. Açaí (Euterpe oleracea martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes’ gene expression in offspring. Biomedicine and pharmacotherapy [online], 139, article ID 111627. Available from: https://doi.org/10.1016/j.biopha.2021.111627

Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression of non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components in mate... Read More about Açaí (Euterpe oleracea martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes’ gene expression in offspring..

A review of lifestyle and environment risk factors for pancreatic cancer. (2021)
Journal Article
ZANINI, S., RENZI, S., LIMONGI, A.R., BELLAVITE, P., GIOVINAZZO, F. and BERMANO, G. 2021. A review of lifestyle and environment risk factors for pancreatic cancer. European journal of cancer [online], 145, pages 53-70. Available from: https://doi.org/10.1016/j.ejca.2020.11.040

Pancreatic cancer (PaCa) is one of the deadliest cancers known and its incidence is increasing in the developed countries. Because of the lack of biomarkers that allow early detection and the tendency of the disease to be asymptomatic, the diagnosis... Read More about A review of lifestyle and environment risk factors for pancreatic cancer..

Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. (2020)
Journal Article
POHL, F., GOUA, M., YATES, K., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2021. Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. Journal of food biochemistry [online], 45(2), article e13592. Available from: https://doi.org/10.1111/jfbc.13592

With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study. For the first time, we highlight the neuroprotective proper... Read More about Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells..

mTOR pathway in gastroenteropancreatic neuroendocrine tumor (GEP-NETs). (2020)
Journal Article
ZANINI, S., RENZI, S., GIOVINAZZO, F. and BERMANO, G. 2020. mTOR pathway in gastroenteropancreatic neuroendocrine tumor (GEP-NETs). Frontiers in endocrinology [online], 11, article ID 562505. Available from: https://doi.org/10.3389/fendo.2020.562505

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) originate from neuroendocrine cells in the gastrointestinal tract. They are heterogeneous, and though initially considered rare tumors, the incidence of GEP-NENs has increased in the last few... Read More about mTOR pathway in gastroenteropancreatic neuroendocrine tumor (GEP-NETs)..

Invited letter to editor in response to: Finland’s handling of selenium is a model in these times of coronavirus infections. (2020)
Journal Article
BERMANO, G., MÉPLAN, C., MERCER, D.K. and HESKETH, J. 2021. Invited letter to editor in response to: Finland's handling of selenium is a model in these times of coronavirus infections. British journal of nutrition [online], 125(12), pages 1439-1440. Available from: https://doi.org/10.1017/s0007114520003839

This response by the authors is in reply to a letter from Ulfberg and Stehlik (https://doi.org/10.1017/S0007114520003827) in comment to the authors' orginal article (https://doi.org/10.1017/S0007114520003128) that suggested that SE status was an impo... Read More about Invited letter to editor in response to: Finland’s handling of selenium is a model in these times of coronavirus infections..

Germination improves the polyphenolic profile and functional value of mung bean (Vigna radiata L.). (2020)
Journal Article
KAPRAVELOU, G., MARTINEZ, R., PERAZZOLI, G., GONZÁLEZ, C.S., LLOPIS, J., CANTARERO, S., GOUA, M., BERMANO, G., PRADOS, J., MELGUIZO, C., ARANDA, P., LÓPEZ-JURADO, M. and PORRES, J.M. 2020. Germination improves the polyphenolic profile and functional value of mung bean (Vigna radiata L.). Antioxidants [online], 9(8), article ID 746. Available from: https://doi.org/10.3390/antiox9080746

The use of legumes as functional foods has gained increasing attention for the prevention and treatment of the so called non-communicable diseases that are highly prevalent worldwide. In this regard, biotechnological approaches for the enhancement of... Read More about Germination improves the polyphenolic profile and functional value of mung bean (Vigna radiata L.)..

Selenium and viral infection: are there lessons for COVID-19? (2020)
Journal Article
BERMANO, G., MÉPLAN, C., MERCER, D.K. and HESKETH, J.E. 2021. Selenium and viral infection: are there lessons for COVID-19? British journal of nutrition [online], 125(6), pages 618-627. Available from: https://doi.org/10.1017/S0007114520003128

Selenium (Se) is a micronutrient that is essential for human health. Sub-optimal Se status is common, occurring in a significant proportion of the population across the world, including parts of Europe and China. Human and animal studies have shown t... Read More about Selenium and viral infection: are there lessons for COVID-19?.

Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis. (2020)
Journal Article
ELLIS, P.E., BARRON, G.A., and BERMANO, G. 2020. Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis. Gynecologic oncology [online], 158(2), pages 507-516. Available from: https://doi.org/10.1016/j.ygyno.2020.05.033

Objective:- To investigate the association between circulating levels of adipocytokines (adiponectin, leptin, tumour necrosis factor alpha (TNFα), interleukin 6 (IL-6)) and growth factors (insulin-like growth factor I (IGF-I) and II (IGF-II)), and th... Read More about Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis..

Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations. (2019)
Journal Article
BHATTA, P., BERMANO, G., WILLIAMS, H.C. and KNOTT, R.M. 2020. Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations. Genomics [online], 112(2), pages 1795-1803. Available from: https://doi.org/10.1016/j.ygeno.2019.10.011

To determine the association of peroxisome proliferator activated receptor gamma coactivator 1 Gly482Ser variant with components of metabolic syndrome. Materials and methods:- A systematic search was carried out using Web of Science, PubMed, EMBASE a... Read More about Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations..

GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. (2019)
Journal Article
POHL, F., TEIXEIRA-CASTRO, A., COSTA, M.D., LINDSAY, V., FIÚZA-FERNANDES, J., GOUA, M., BERMANO, G., RUSSELL, W., MACIEL, P. and KONG THOO LIN, P. 2019. GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. Frontiers in neuroscience [online], 13, article ID 1091. Available from: https://doi.org/10.3389/fnins.2019.01091

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson’s disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as impor... Read More about GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation..

Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring. (2019)
Journal Article
BARBOSA, P.O., DE SOUZA, M.O., PAIVA, D.P.D., SILVA, M.E., LIMA, W.G., BERMANO, G. and FREITAS, R.N. 2020. Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring. European journal of nutrition [online], 59(5), pages 1595-1908. Available from: https://doi.org/10.1007/s00394-019-02040-2

Purpose: Maternal high-fat diet affects offspring and can induce metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). New therapeutic strategies are being investigated as way to prevent or attenuate this condition. The objective of... Read More about Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring..

Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence. (2018)
Journal Article
DONADIO, J.L.S., LIU, L., FREEMAN, V.L., EKOUE, D.N., DIAMOND, A.M. and BERMANO, G. 2018. Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence. Prostate [online], 79(5), pages 462-467. Available from: https://doi.org/10.1002/pros.23752

Background: NKX3.1 is a tumor suppressor frequently lost in prostate cancer. Previous studies by others indicated that the risks associated with reduced NKX3.1 levels can be enhanced by anti-oxidant supplementation. Selenium is an essential component... Read More about Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence..

Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. (2017)
Journal Article
BARRON, G.A., GOUA, M., WAHLE, K.W.J. and BERMANO, G. 2017. Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. Oncology reports [online], 38(3), pages 1886-1894. Available from: https://doi.org/10.3892/or.2017.5803

The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matche... Read More about Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation..

Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. (2017)
Journal Article
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., SCOBBIE, L., MACIEL, P. and KONG THOO LIN, P. 2018. Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. Food chemistry [online], 239, pages 323-332. Available from: https://doi.org/10.1016/j.foodchem.2017.06.129

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. Analysis of ubiquitous secondary metabolites in RSP samples (two breeds, harvested in 2012/2014 respectively from North East of Scotland) and their eth... Read More about Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties..

Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. (2016)
Journal Article
KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], 14(41), pages 9780-9789. Available from: https://doi.org/10.1039/C6OB01850E

Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and cytotoxic activities. By modifyi... Read More about Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells..

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. (2015)
Journal Article
BARRON, G.A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and KONG THOO LIN, P. 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-biological interactions [online], 242, pages 307-315. Available from: https://doi.org/10.1016/j.cbi.2015.10.017

Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier work was extended to investiga... Read More about Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression..

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