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Impact of the MTHFR C677T polymorphism on blood pressure and related central hemodynamic parameters in healthy adults. (2022)
Journal Article
ROONEY, M., HUGHES, C.F., STRAIN, J.J., CLEMENTS, M., MCNULTY, H. and WARD, M. 2022. Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults. Journal of human nutrition and dietetics [online], 35(4): gene-environment interactions in human health, pages 689-700. Available from: https://doi.org/10.1111/jhn.13061

Background: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator of blood pr... Read More about Impact of the MTHFR C677T polymorphism on blood pressure and related central hemodynamic parameters in healthy adults..

Impact of the MTHFR C677T polymorphism on one-carbon metabolites: evidence from a randomised trial of riboflavin supplementation. (2020)
Journal Article
ROONEY, M., BOTTIGLIERI, T., WASEK-PATTERSON, B., MCMAHON, A., HUGHES, C.F., MCCANN, A., HORIGAN, G., STRAIN, J.J., MCNULTY, H. and WARD, M. 2020. Impact of the MTHFR C677T polymorphism on one-carbon metabolites: evidence from a randomised trial of riboflavin supplementation. Biochimie [online], 173, pages 91-99. Available from: https://doi.org/10.1016/j.biochi.2020.04.004

Homozygosity for the C677T polymorphism in MTHFR (TT genotype) is associated with a 24–87% increased risk of hypertension. Blood pressure (BP) lowering was previously reported in adults with the TT genotype, in response to supplementation with the MT... Read More about Impact of the MTHFR C677T polymorphism on one-carbon metabolites: evidence from a randomised trial of riboflavin supplementation..