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All Outputs (9)

An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome. (2018)
Thesis
BHATTA, P. 2018. An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome. Robert Gordon University, PhD thesis.

Type 2 diabetes and metabolic syndrome are the metabolic disorders which constitute a major public health problem in both developed and developing countries. Various studies have suggested the genetic susceptibility to the disorders. The main aim of... Read More about An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome..

Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes. (2016)
Thesis
AL ALI, F.M. 2016. Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes. Robert Gordon University, MRes thesis.

Diabetes mellitus (DM) is the most common metabolic disease worldwide. This condition accounts for the majority of renal failure and blindness in adults aged between 20 to 74 years of age. After 20 years, some of type 1 diabetic patients and around 6... Read More about Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes..

Control of surface interactions with ultra-violet/ozone modification at polystyrene surface. (2014)
Thesis
LIANG, H. 2014. Control of surface interactions with ultra-violet/ozone modification at polystyrene surface. Robert Gordon University, PhD thesis.

Surface interactions and reactivity are of critical importance in current biomedical technologies, for example, satisfactory cell attachment and long term viability are essential for optimal in vitro tissue culture and for successful implantation and... Read More about Control of surface interactions with ultra-violet/ozone modification at polystyrene surface..

Novel polyelectrolyte complexes for oral insulin delivery. (2013)
Thesis
IBIE, C.O. 2013. Novel polyelectrolyte complexes for oral insulin delivery. Robert Gordon University, PhD thesis.

Oral delivery of insulin used for the management of Type 1 diabetes could be referred to as one of the major long-term goals of diabetes research. However, the bioavailability of orally-administrered insulin is significantly compromised by enzymatic... Read More about Novel polyelectrolyte complexes for oral insulin delivery..

The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. (2011)
Thesis
GADAD, P.C. 2011. The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. Robert Gordon University, PhD thesis.

Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment o... Read More about The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies..

Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. (2010)
Thesis
SKENE, K.E. 2010. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. Robert Gordon University, PhD thesis.

Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive th... Read More about Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation..

Cytochrome P450 mRNA profile in human breast cancer cell lines. (2008)
Thesis
WARASIHA, B. 2008. Cytochrome P450 mRNA profile in human breast cancer cell lines. Robert Gordon University, PhD thesis.

Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites deriv... Read More about Cytochrome P450 mRNA profile in human breast cancer cell lines..

Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. (2008)
Thesis
WEIDMANN, A.E. 2008. Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. Robert Gordon University, PhD thesis.

Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in the endothelium are of particul... Read More about Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells..

Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. (2007)
Thesis
HECTOR, E.E. 2007. Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. Robert Gordon University, PhD thesis.

Poorly-controlled diabetes mellitus is associated with the development of chronic vascular complications, which cause morbidity and premature mortality. Many studies have highlighted that maintenance of normal blood glucose levels in all people with... Read More about Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells..