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All Outputs (134)

Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. (2013)
Thesis
MEDU, E.O. 2013. Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. Robert Gordon University, PhD thesis.

Bacterial resistance is an increasing challenge across the world, which means that there is an urgent need for the rational development of antibacterial compounds that have either novel or multiple mechanisms of action. This study demonstrated that t... Read More about Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B..

Combined effects of bioavailable organic contaminants in the aquatic environment. (2013)
Thesis
EMELOGU, E.S. 2013. Combined effects of bioavailable organic contaminants in the aquatic environment. Robert Gordon University, PhD thesis.

In contrast to conventional spot or bottle water sampling techniques, passive sampling has been shown to be a reliable and efficient method for monitoring the toxicologically-relevant, freely-dissolved (e.g. bioavaialable) concentrations of a wide ra... Read More about Combined effects of bioavailable organic contaminants in the aquatic environment..

Investigation of the production and isolation of bioactive compounds from cyanobacteria. (2013)
Thesis
HAMEED, S. 2013. Investigation of the production and isolation of bioactive compounds from cyanobacteria. Robert Gordon University, PhD thesis.

Due to heavy nutrient load and adverse climate change the occurrence of toxic cyanobacterial blooms have significantly increased during the last decades. Nodularia spumigena is one of the dominant toxic cyanobacteria which produces massive and inhere... Read More about Investigation of the production and isolation of bioactive compounds from cyanobacteria..

Freshwater bacterial diversity, functions and stability. (2013)
Thesis
GIARAMIDA, L. 2013. Freshwater bacterial diversity, functions and stability. Robert Gordon University, PhD thesis.

Biodiversity is declining worldwide with detrimental effects on ecosystems functions and services that it sustains. The relationship between biodiversity and freshwater purification remains unclear. Freshwater purification is of paramount importance... Read More about Freshwater bacterial diversity, functions and stability..

Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water. (2013)
Thesis
CHANDU, V.C.P 2013. Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water. Robert Gordon University, PhD thesis.

The widespread distribution of cyanobacteria and their toxic effects on humans has become a major concern for researchers. Cyanobacteria are a group of oxygenic phototrophic bacteria that exhibit an enormous diversity in shapes and arrangements and o... Read More about Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water..

Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids? (2012)
Thesis
MICHEL, L. 2012. Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids? Robert Gordon University, PhD thesis.

The ω-3 polyunsaturated fatty acids (ω-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to have cardioprotective and antiatherosclerotic actions. While it has been proposed that ω-3 PUFAs may structurally stabi... Read More about Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?.

Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems. (2012)
Thesis
PESTANA, C.J. 2012. Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems. Robert Gordon University, PhD thesis.

Cyanobacterial secondary metabolites can cause serious harm to animals and humans (cyanotoxins) and can have a major financial impact on the potable water and aquaculture industries (taste and odour compounds). Understanding the factors that affect c... Read More about Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems..

An investigation into the biodegradation of peptide cyanotoxins (microcystins and nodularin) by novel gram-positive bacteria. (2012)
Thesis
WELGAMAGE DON, A.C.D. 2012. An investigation into the biodegradation of peptide cyanotoxins (microcystins and nodularin) by novel gram-positive bacteria. Robert Gordon University, PhD thesis.

Cyanobacterial secondary metabolites, microcystins (MC) and nodularin (NOD) have become common contaminants in most aquatic ecosystems over recent years presenting a hazard to animal and human health. Unfortunately, these chemically diverse peptide h... Read More about An investigation into the biodegradation of peptide cyanotoxins (microcystins and nodularin) by novel gram-positive bacteria..

An investigation of the structures and processes of pharmacist prescribing in Great Britain: a mixed methods approach. (2012)
Thesis
DAPAR, M.P. 2012. An investigation of the structures and processes of pharmacist prescribing in Great Britain: a mixed methods approach. Robert Gordon University, PhD thesis.

The aim of this research was to investigate the structures and processes of pharmacist prescribing in Great Britain, focusing on primary care settings. A sequential, mixed-methods approach was employed in the conduct of the research. The first phase... Read More about An investigation of the structures and processes of pharmacist prescribing in Great Britain: a mixed methods approach..

Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease. (2011)
Thesis
ROWELL, O. 2011. Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease. Robert Gordon University, MRes thesis.

Atherosclerosis is a cardiovascular disease which forms plaques which narrow the arteries, restricting blood flow and thus increasing blood pressure. As this can lead to more serious conditions, such as myocardial infarction, it is important that ath... Read More about Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease..

Antimicrobial wafers as a novel technology for infection control in chronic wounds. (2011)
Thesis
LABOVITIADI, O. 2011. Antimicrobial wafers as a novel technology for infection control in chronic wounds. Robert Gordon University, PhD thesis.

Bacterial contamination and persistent infection is a common cause of impaired wound healing. Generally, non-healing wounds display similar physiological features with regards to mixed bacterial flora, ischemia and production of exudate. The applicat... Read More about Antimicrobial wafers as a novel technology for infection control in chronic wounds..

Formulation studies on cysteamine for the treatment of nephropathic cystinosis. (2011)
Thesis
BUCHAN, B.E. 2011. Formulation studies on cysteamine for the treatment of nephropathic cystinosis. Robert Gordon University, PhD thesis.

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of almost all organs. It is treated by regular oral and topical administration of the aminothiol, cysteamine (Cystagon TM),... Read More about Formulation studies on cysteamine for the treatment of nephropathic cystinosis..

Investigation into the antimicrobial activity of cationic antibacterials. (2011)
Thesis
O'DRISCOLL, N.H. 2011. Investigation into the antimicrobial activity of cationic antibacterials. Robert Gordon University, PhD thesis.

The topic addressed by the 2011 WHOs World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation focussed on the action... Read More about Investigation into the antimicrobial activity of cationic antibacterials..

Exploring pharmacist prescribing in hospitals in Scotland, with a focus on antimicrobials. (2011)
Thesis
TONNA, A.P. 2011. Exploring pharmacist prescribing in hospitals in Scotland, with a focus on antimicrobials. Robert Gordon University, PhD thesis.

This aim of the research was to explore pharmacist prescribing (PP) with a focus on antimicrobials, in hospitals in Scotland. A mixed-methods approach was used to collect, generate and synthesise data. A systematic review of peer-reviewed published l... Read More about Exploring pharmacist prescribing in hospitals in Scotland, with a focus on antimicrobials..

The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation. (2011)
Thesis
CASSIDY, S.M. 2011. The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation. Robert Gordon University, MRes thesis.

Photodynamic therapy is a relatively new treatment for various cancers and other diseases using a photosensistiser that produces cytotoxic singlet oxygen (1O2) after light irradiation. Current approved photosensitisers have limitations, such as a low... Read More about The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation..

An exploration of Scottish community pharmacists' adoption of innovative services and products relating to minor ailment management. (2011)
Thesis
PAUDYAL, V. 2011. An exploration of Scottish community pharmacists' adoption of innovative services and products relating to minor ailment management. Robert Gordon University, PhD thesis.

This research utilised mixed methodology to gain insight into community pharmacists adoption of medicines and services related to two key innovative policy interventions aimed at enhanced minor ailment management; namely the ongoing legal status recl... Read More about An exploration of Scottish community pharmacists' adoption of innovative services and products relating to minor ailment management..

The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. (2011)
Thesis
GADAD, P.C. 2011. The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. Robert Gordon University, PhD thesis.

Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment o... Read More about The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies..

The effect of raw and processed vegetables on colonocyte dna damage. (2011)
Thesis
LYNN, A. 2011. The effect of raw and processed vegetables on colonocyte dna damage. Robert Gordon University, PhD thesis.

Cruciferous vegetables and their bioactive constituents have been shown to inhibit chemically-induced colon cancer (IARC, 2004). However, the results of epidemiological studies have been inconsistent (IARC, 2004). This may reflect a lack of sensitivi... Read More about The effect of raw and processed vegetables on colonocyte dna damage..

Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. (2010)
Thesis
IBIE, C.O. 2010. Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. Robert Gordon University, MRes thesis.

Modified-release multiparticulate pellets have been produced by the process of extrusion and spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosi... Read More about Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis..

The characterisation and identification of body fluid proteins for forensic purposes. (2010)
Thesis
VINCINI, L. 2010. The characterisation and identification of body fluid proteins for forensic purposes. Robert Gordon University, PhD thesis.

Advances in DNA technology have led to the extremely sensitive and rapid analysis methods used in forensic science. It can often be crucial to a criminal case to unequivocally identify the body fluid source of DNA. This is of particular importance in... Read More about The characterisation and identification of body fluid proteins for forensic purposes..