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Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease. (2011)
Thesis
ROWELL, O. 2011. Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease. Robert Gordon University, MRes thesis.

Atherosclerosis is a cardiovascular disease which forms plaques which narrow the arteries, restricting blood flow and thus increasing blood pressure. As this can lead to more serious conditions, such as myocardial infarction, it is important that ath... Read More about Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease..

The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery. (2011)
Journal Article
CLARE, H., KONG THOO LIN, P., TETLEY, L. and CHENG, W.P. 2012. The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery. Pharmaceutical research [online], 29(3), pages 782-794. Available from: https://doi.org/10.1007/s11095-011-0602-7

Purpose: To investigate the use of nano self-assemblies formed by polyallylamine (PAA) modified with 5 or 10% mole fluorenylmethoxy carbonyl (Fmoc5/10), dimethylamino-1-naphthalenesulfonyl (Dansyl5/10) and 5% mole cholesteryl group (Ch5) for oral hyd... Read More about The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery..

Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs. (2011)
Journal Article
GU, J., CHENG, W.P., HOSKINS, C., KONG THOO LIN, P., ZHAO, L, ZHU, L., QU, X. and YANG, Z. 2011. Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs. Journal of microencapsulation [online], 28(8): micro and nano carriers, pages 752-762. Available from: https://doi.org/10.3109/02652048.2011.615951

The physicochemical compatibility between amphiphilic polymers and hydrophobic drugs has been recognized as an important issue for improving the drug solubilisation in polymeric micelle formulations. In this work, poly-L-lysine (PLL) grafted by chola... Read More about Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs..

Antimicrobial wafers as a novel technology for infection control in chronic wounds. (2011)
Thesis
LABOVITIADI, O. 2011. Antimicrobial wafers as a novel technology for infection control in chronic wounds. Robert Gordon University, PhD thesis.

Bacterial contamination and persistent infection is a common cause of impaired wound healing. Generally, non-healing wounds display similar physiological features with regards to mixed bacterial flora, ischemia and production of exudate. The applicat... Read More about Antimicrobial wafers as a novel technology for infection control in chronic wounds..

Formulation studies on cysteamine for the treatment of nephropathic cystinosis. (2011)
Thesis
BUCHAN, B.E. 2011. Formulation studies on cysteamine for the treatment of nephropathic cystinosis. Robert Gordon University, PhD thesis.

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of almost all organs. It is treated by regular oral and topical administration of the aminothiol, cysteamine (Cystagon TM),... Read More about Formulation studies on cysteamine for the treatment of nephropathic cystinosis..

Investigation into the antimicrobial activity of cationic antibacterials. (2011)
Thesis
O'DRISCOLL, N.H. 2011. Investigation into the antimicrobial activity of cationic antibacterials. Robert Gordon University, PhD thesis.

The topic addressed by the 2011 WHOs World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation focussed on the action... Read More about Investigation into the antimicrobial activity of cationic antibacterials..

Exploring pharmacist prescribing in hospitals in Scotland, with a focus on antimicrobials. (2011)
Thesis
TONNA, A.P. 2011. Exploring pharmacist prescribing in hospitals in Scotland, with a focus on antimicrobials. Robert Gordon University, PhD thesis.

This aim of the research was to explore pharmacist prescribing (PP) with a focus on antimicrobials, in hospitals in Scotland. A mixed-methods approach was used to collect, generate and synthesise data. A systematic review of peer-reviewed published l... Read More about Exploring pharmacist prescribing in hospitals in Scotland, with a focus on antimicrobials..

A study of the kinetic solvent isotope effect on the destruction of microcystin-LR and geosmin using TiO2 photocatalysis. (2011)
Journal Article
ROBERTSON, P.K.J., BAHNEMANN, D.W., LAWTON, L.A. and BELLU, E. 2011. A study of the kinetic solvent isotope effect on the destruction of microcystin-LR and geosmin using TiO2 photocatalysis. Applied catalysis B: environmental [online], 108-109, pages 1-5. Available from: https://doi.org/10.1016/j.apcatb.2011.07.019

We have previously reported the effectiveness of TiO2 photocatalysis in the destruction of species generated by cyanobacteria, specifically geosmin and microcystin-LR. In this paper we report an investigation of factors which influence the rate of th... Read More about A study of the kinetic solvent isotope effect on the destruction of microcystin-LR and geosmin using TiO2 photocatalysis..

The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation. (2011)
Thesis
CASSIDY, S.M. 2011. The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation. Robert Gordon University, MRes thesis.

Photodynamic therapy is a relatively new treatment for various cancers and other diseases using a photosensistiser that produces cytotoxic singlet oxygen (1O2) after light irradiation. Current approved photosensitisers have limitations, such as a low... Read More about The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation..

In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase. (2011)
Journal Article
KUSCH, P., DEININGER, S., SPECHT, S., MANIAKO, R., HAUBRICH, S., POMMERENING, T., KONG THOO LIN, P., HOERAUF, A. and KAISER, A. 2011. In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase. Journal of parasitology research [online], 2011, article ID 368692. Available from: https://doi.org/10.1155/2011/368692

Balanites aegyptiaca (Balanitaceae) is a widely grown desert plant with multiuse potential. In the present paper, a crude extract from B. aegyptiaca seeds equivalent to a ratio of 1:2000 seeds to the extract was screened for antiplasmodial activity.... Read More about In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase..

An exploration of Scottish community pharmacists' adoption of innovative services and products relating to minor ailment management. (2011)
Thesis
PAUDYAL, V. 2011. An exploration of Scottish community pharmacists' adoption of innovative services and products relating to minor ailment management. Robert Gordon University, PhD thesis.

This research utilised mixed methodology to gain insight into community pharmacists adoption of medicines and services related to two key innovative policy interventions aimed at enhanced minor ailment management; namely the ongoing legal status recl... Read More about An exploration of Scottish community pharmacists' adoption of innovative services and products relating to minor ailment management..

The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. (2011)
Thesis
GADAD, P.C. 2011. The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. Robert Gordon University, PhD thesis.

Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment o... Read More about The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies..

The effect of raw and processed vegetables on colonocyte dna damage. (2011)
Thesis
LYNN, A. 2011. The effect of raw and processed vegetables on colonocyte dna damage. Robert Gordon University, PhD thesis.

Cruciferous vegetables and their bioactive constituents have been shown to inhibit chemically-induced colon cancer (IARC, 2004). However, the results of epidemiological studies have been inconsistent (IARC, 2004). This may reflect a lack of sensitivi... Read More about The effect of raw and processed vegetables on colonocyte dna damage..