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Gα15 as a novel player in the complex signalling network connected with insulin/insulin-like growth factor-1 (IGF-1) pathway in pancreatic ductal adenocarcinoma (PDAC)

People Involved

Project Description

Pancreatic Ductal AdenoCarcinoma (PDAC), the most common type of pancreatic cancer (PaCa), is one of the most lethal diseases with less than 1% surviving for 10 or more years. In 2012, 8,875 people in the UK were diagnosed with pancreatic cancer and 8,662 deaths, due to pancreatic cancer, were registered in the same year.

To-date no effective therapies are available and the identification of new factors involved in the cancer process could help to understand the causes of PDAC progression and identify new pharmacological targets for treatment.

Obesity is a recognized risk factor for PaCa and a predisposing factor for the development of diabetes. In this scenario, pancreas secretes more insulin and another growth factor closely related to insulin (insulin-like growth factor-1 or IGF-1) becomes more bioavailable. They both promote the growth of PaCa cells increasing the risk to develop PaCa.

Type of Project Project
Status Project Live
Funder(s) Friends of Anchor
Value £9,000.00
Project Dates Jan 3, 2018 - Dec 31, 2021

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