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The application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases

People Involved

Professor Paul Kong Thoo Lin

Doctor Giovanna Bermano

Professor Cherry Wainwright

Doctor Marie Goua

Doctor Marie Goua
Teaching Group Leader

Project Description

Neurodegenerative diseases such as Alzheimer's and Parkinsonism currently affect a large proportion of the world population, and this is expected to double every 20 years to 81.1 million by 2040. One contributing factor to this predicted number in neurodegenerative diseases is the increased life expectancy of the human population in general. These dramatic increases will cause a huge financial burden to our national health service.

To date, there are no effective drugs developed to combat these neurological diseases. Neuro-active extracts and/or compounds from plants may provide prophylactic and/or new therapeutic actions, leading to a reduction in the incidence, or even an improvement, of some neurological conditions. Recently, it was suggested that novel therapeutic strategies for neurological diseases could be based on ROS (reactive active oxygen) scavengers as monotherapy or as part of a multi-target cocktail formulation for the treatment of neurological diseases.

One important source of easily accessible ROS scavengers is from Rapeseed (Brassica napus) pomace. The latter is a waste product from rapeseed oil production and 35 million tons are produced every year worldwide.

This project aims
(i) to develop a 'green/organic' method to extract bioactive natural products from rapeseed pomace
(ii) to determine the profile and concentrations of bioactive compounds present in the extracts,
(iii) to determine the toxicity and antioxidant properties of extracts at cellular levels
(iv) to study the neuroprotective effects of rapeseed pomace extracts
(v) to study the efficacy of pomace extracts in rescuing phenotypes in neurodegenerative diseases and
(vi) to produce a business plan for any potential product development.

Type of Project Project
Status Project Live
Funder(s) Tenovus Scotland
Value £80,000.00
Project Dates Oct 1, 2014 - Jul 31, 2020

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