Development of Fast Field MRI as a novel method to monitor liver regeneration in non-alcoholic fatty liver disease (NAFLD) Mar 1, 2018 - Feb 28, 2019
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sFRPs as a novel modulator of diastolic heart failure Oct 1, 2017 - Sep 30, 2021
Following a heart attack, or because of persistently high blood pressure the heart is damaged and has to work harder to circulate blood around the body. This condition is known as heart failure. In the UK alone, 500,000 people have heart failure re... Read More

A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity Apr 1, 2017 - Apr 30, 2021
Colorectal cancer (CRC) incidence is rising steadily and in parallel with increasing prevalence of obesity in Scotland. Recent data indicate that the highest incidence rates are in the North East. The increasing prevalence of obes... Read More

Gα15 as a novel player in the complex signalling network connected with insulin/insulin-like growth factor-1 (IGF-1) pathway in pancreatic ductal adenocarcinoma (PDAC) Jan 3, 2018 - Apr 30, 2021
Pancreatic Ductal AdenoCarcinoma (PDAC), the most common type of pancreatic cancer (PaCa), is one of the most lethal diseases with less than 1% surviving for 10 or more years. In 2012, 8,875 people in the UK were diagnosed with pancreatic cancer and... Read More

The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2 Jul 1, 2017 - Dec 31, 2019
Medicinal use of natural products, such as, extracts from plants have existed for many years particularly in China and are now widely available around the world. Several different types of cancer including breast cancer are becoming insensitive and r... Read More

Processes for screening Streptomyces sp. Jan 5, 2016 - Jan 4, 2019
To initiate exploitation of the NCIMB Culture Collection by developing knowledge and processes for screening Streptomyces sp. for novel natural commercial products and the development of new product lines

The application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases Oct 1, 2014 - Jul 31, 2020
Neurodegenerative diseases such as Alzheimer's and Parkinsonism currently affect a large proportion of the world population, and this is expected to double every 20 years to 81.1 million by 2040. One contributing factor to this predicted number in ne... Read More

Sustainable energy from photocatalytic bioremediation of waste Apr 1, 2013 - Apr 1, 2018
Increasing demand for energy remains globally unsustainable with decreasing fossil fuel supplies, rising prices and green house gas emissions. There has been a growing worldwide interest in alternative clean energy sources including biofuels to limit... Read More

Investigating value as perceived and experienced by service users (Year 1) Jan 1, 2018 - Dec 31, 2018
Community Pharmacy Scotland has commissioned Robert Gordon University and the University of Strathclyde to research the value of community pharmacy in Scotland as perceived and experienced by service users. The two universities will collaborate throu... Read More

Safe and Sustainable Shellfish: Introducing local testing and management solutions Jan 1, 2019 - Dec 31, 2021
Phytoplankton (algae) are essential in marine ecosystems but some species produce biotoxins that can accumulate in harvested shellfish, posing a threat to human health.

Harvesting of shellfish, including mussels, scallops and oysters,... Read More

Defining the emerging roles of GPR55 Oct 1, 2019 - Mar 31, 2022
The G-protein coupled receptor (GPCR) superfamily play crucial roles in cell communication. Given their involvement in neurological disorders, inflammatory and metabolic diseases, diabetes and cardiac dysfunction they represent the largest and most s... Read More

Extracting added value from the Seaweed Industry - a search for novel anti-obesity agents Oct 1, 2018 - Sep 30, 2022
Seaweed farming is a growing industry in the UK, with the majority of the biomass being used for the extraction of high yield products such as aliginates, or for use as biofuels.

However, a significant amount of the biomass remains u... Read More

Rapid Analysis Method for Cyanobacterial Toxins Mar 1, 2018 - Feb 29, 2020
Develop a rapid multi-toxin liquid chromatography method for monitoring of cyanobacterial toxins in potable water in the semi arid region of North East Brazil where most drinking water is sourced from surface reservoirs. Water quality in the region i... Read More

Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction Oct 1, 2018 - Jan 1, 2021
Zinc (Zn 2+) is a metal found in trace amounts in the body and plays an essential role in maintaining the healthy functioning of most organs, including the heart. The body does not store zinc in large quantities and so replenishment of Zn 2+ through... Read More

Novel anti-cancer drug candidates: Bisnaphthalimidopropyl (BNIPs) derivatives for the treatment of human metastatic colorectal cancer Sep 1, 2018 - Aug 31, 2021

Protective effects of cannabidiol in doxorubicin induced cardiotoxicity Oct 1, 2018 - Dec 31, 2019

Safe Water for Sri Lanka Jan 31, 2019 - Jan 30, 2022
Freshwater is usually available in Sri Lanka, however around 50% of the country depends on single-household dug wells. Despite preconceptions that there is a low risk of contamination in well water, we have recently found the presence of cyanobacteri... Read More

Valorisation of waste biomass from the production of phycocyanin Feb 1, 2019 - Jan 31, 2021
To develop the knowledge and capability for valorisation of waste biomass from the production of phycocyanin, to develop a versatile co-product platform using green/food processing technologies delivering high quality products manufactured in a Good... Read More

Environmental risk assessment of human pharmaceuticals in Scottish marine waters; combining new exposure and effect driven monitoring approaches Mar 15, 2019 - Mar 14, 2020
Our oceans and seas are the final destination for pollutants present in wastewaters from households, hospitals and industry. It is now recognised that ‘dilution isn’t the solution’ and pollutants from land have a negative impact on marine life. Pol... Read More

Protective effects of cannabidiol in combined chemotherapy induced cardiotoxicity Jul 8, 2019 - Sep 1, 2019
Doxorubicin, an anthracycline, is one of the most effective and commonly used drugs for the treatment of cancer. This anthracycline is used both alone and in combination with other chemotherapeutic agents such as taxanes e.g. paclitaxel. Despite its... Read More