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All Projects (70)

A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity Apr 1, 2017 - Dec 31, 2021
Colorectal cancer (CRC) incidence is rising steadily and in parallel with increasing prevalence of obesity in Scotland. Recent data indicate that the highest incidence rates are in the North East. The increasing prevalence of obes... Read More about A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity.

Gα15 as a novel player in the complex signalling network connected with insulin/insulin-like growth factor-1 (IGF-1) pathway in pancreatic ductal adenocarcinoma (PDAC) Jan 3, 2018 - Dec 31, 2021
Pancreatic Ductal AdenoCarcinoma (PDAC), the most common type of pancreatic cancer (PaCa), is one of the most lethal diseases with less than 1% surviving for 10 or more years. In 2012, 8,875 people in the UK were diagnosed with pancreatic cancer and... Read More about Gα15 as a novel player in the complex signalling network connected with insulin/insulin-like growth factor-1 (IGF-1) pathway in pancreatic ductal adenocarcinoma (PDAC).

The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2 Jul 1, 2017 - Dec 31, 2019
Medicinal use of natural products, such as, extracts from plants have existed for many years particularly in China and are now widely available around the world. Several different types of cancer including breast cancer are becoming insensitive and r... Read More about The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2.

Processes for screening Streptomyces sp. Jan 5, 2016 - Jan 4, 2019
To initiate exploitation of the NCIMB Culture Collection by developing knowledge and processes for screening Streptomyces sp. for novel natural commercial products and the development of new product lines

The application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases Oct 1, 2014 - Jul 31, 2020
Neurodegenerative diseases such as Alzheimer's and Parkinsonism currently affect a large proportion of the world population, and this is expected to double every 20 years to 81.1 million by 2040. One contributing factor to this predicted number in ne... Read More about The application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases.

Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction Oct 1, 2018 - Jan 1, 2021
Zinc (Zn 2+) is a metal found in trace amounts in the body and plays an essential role in maintaining the healthy functioning of most organs, including the heart. The body does not store zinc in large quantities and so replenishment of Zn 2+ through... Read More about Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction.

Safe Water for Sri Lanka Jan 31, 2019 - Mar 31, 2022
Freshwater is usually available in Sri Lanka, however around 50% of the country depends on single-household dug wells. Despite preconceptions that there is a low risk of contamination in well water, we have recently found the presence of cyanobacteri... Read More about Safe Water for Sri Lanka.

Environmental risk assessment of human pharmaceuticals in Scottish marine waters; combining new exposure and effect driven monitoring approaches Mar 15, 2019 - Mar 14, 2020
Our oceans and seas are the final destination for pollutants present in wastewaters from households, hospitals and industry. It is now recognised that ‘dilution isn’t the solution’ and pollutants from land have a negative impact on marine life. Pol... Read More about Environmental risk assessment of human pharmaceuticals in Scottish marine waters; combining new exposure and effect driven monitoring approaches.