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Temperature effects explain continental scale distribution of cyanobacterial toxins. (2018)
Journal Article
MANTZOUKI, E., IBELINGS, B.W., FASTNER, J., LÜRLING, M., DE SENERPONT DOMIS, L., TEURLINCX, S. and CHMURA, D. 2018. Temperature effects explain continental scale distribution of cyanobacterial toxins. Toxins [online], 10(4), article number 156. Available from: https://doi.org/10.3390/toxins10040156

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other c... Read More about Temperature effects explain continental scale distribution of cyanobacterial toxins..

Cell lysis and detoxification of cyanotoxins using a novel combination of microbubble generation and plasma microreactor technology for ozonation. (2018)
Journal Article
PANDHAL, J., SISWANTO, A., KUVSHINOV, D., ZIMMERMAN, W.B., LAWTON, L. and EDWARDS, C. 2018. Cell lysis and detoxification of cyanotoxins using a novel combination of microbubble generation and plasma microreactor technology for ozonation. Frontiers in microbiology [online], 9, article number 678. Available from: https://doi.org/10.3389/fmicb.2018.00678

There has been a steady rise in the global incidences of algal blooms and, worryingly, there is increasing evidence that changes in the global climate are leading to a shift toward cyanobacterial blooms. Many cyanobacterial genera are harmful, produc... Read More about Cell lysis and detoxification of cyanotoxins using a novel combination of microbubble generation and plasma microreactor technology for ozonation..

Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. (2017)
Journal Article
TURNER, A.D., WAACK, J., LEWIS, A., EDWARDS, C. and LAWTON, L. 2018. Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. Journal of chromatography B [online], 1074-1075, pages 111-123. Available from: https://doi.org/10.1016/j.jchromb.2017.12.032

A simple, rapid UHPLC-MS/MS method has been developed and optimised for the quantitation of microcystins and nodularin in wide variety of sample matrices. Microcystin analogues targeted were MC-LR, MC-RR, MC-LA, MC-LY, MC-LF, LC-LW, MC-YR, MC-WR, [As... Read More about Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders..

Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis. (2017)
Thesis
WAACK, J. 2017. Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis. Robert Gordon University, PhD thesis.

Cyanobacteria produce a variety of secondary metabolites that possess - amongst other things - antifungal, antibacterial and antiviral properties. Being primary producers, they are also a vital component within the food web. However, certain strains... Read More about Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis..

Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66. (2017)
Journal Article
HAMEED, S., LAWTON, L.A., EDWARDS, C., KHAN, A., FAROOQ, U. and KHAN, F.A. 2017. Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66. Journal of applied phycology [online], 29(4), pages 1801-1810. Available from: https://doi.org/10.1007/s10811-017-1115-5

Nodularia spumigena is one of the dominant toxic cyanobacteria which produce blooms in the Baltic Sea, a brackish water body, particularly in late summer. Nodularia spp. are known to produce hepatotoxic nodularins (NODs) and other bioactive peptides... Read More about Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66..

Hepatotoxic-microcystins in two drinking water reservoirs in the central region of Ghana. (2017)
Journal Article
ADDICO, G.N.D., LAWTON, L. and EDWARDS, C. 2017. Hepatotoxic-microcystins in two drinking water reservoirs in the central region of Ghana. Toxicology and forensic medicine [online], 2(1), pages 1-11. Available from: https://doi.org/10.17140/TFMOJ-2-111

Background: Microcystins are cyclic peptides containing seven amino acids with the condensation of two terminal amino acids of the linear peptide to form a cyclic compound. The cyclic nature of microcystins suggests that they are highly stable in wat... Read More about Hepatotoxic-microcystins in two drinking water reservoirs in the central region of Ghana..

Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides. (2017)
Journal Article
PHOTOS-JONES, E., EDWARDS, C., HANER, F., LAWTON, L., KEAN, C., LEANORD, A. and PERDIKATSIS, V. 2017. Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides. Geological society: special publications. Geology and medicine: historical connections [online], 452, pages 141-153. Available from: https://doi.org/10.1144/SP452.6

This paper presents the scientific investigation of three Lemnian sphragides (terra sigillata), a famed medicinal clay (earth) of antiquity, dated to the 16th-17th century, and presently in the collection of the Museum for the History of Pharmacy of... Read More about Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides..

Evidence for functional drift of bacterial isolates in response to cyanobacterial microcystin-lr and multiple peptide degradation in paucibacter toxinivorans. (2016)
Thesis
KREITZ, J. 2016. Evidence for functional drift of bacterial isolates in response to cyanobacterial microcystin-lr and multiple peptide degradation in paucibacter toxinivorans. Robert Gordon University, MPhil thesis.

Bacterial bioremediation has been proposed as an efficient, low cost and ecologically safe method to clean vital water reservoirs from cyanobacterial peptide toxins microcystins (MCs). In previous work carried out in 2008 several bacteria were isolat... Read More about Evidence for functional drift of bacterial isolates in response to cyanobacterial microcystin-lr and multiple peptide degradation in paucibacter toxinivorans..

Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors. (2016)
Journal Article
LANCE, E., DESPRAT, J., HOLBECH, B.F., GERARD, C., BORMANS, M., LAWTON, L.A., EDWARDS, C. and WIEGAND, C. 2016. Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors. Aquatic toxicology [online], 177, pages 116-124. Available from: https://doi.org/10.1016/j.aquatox.2016.05.024

Freshwater gastropods are increasingly exposed to multiple stressors in the field such as the herbicide glyphosate in Roundup formulations and cyanobacterial blooms either producing or not producing microcystins (MCs), potentially leading to interact... Read More about Accumulation and detoxication responses of the gastropod Lymnaea stagnalis to single and combined exposures to natural (cyanobacteria) and anthropogenic (the herbicide RoundUp® Flash) stressors..

Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning. (2016)
Journal Article
DELGADO-BAQUERIZO, M., GIARAMIDA, L., REICH, P.B., KHACHANE, A.N., HAMONTS, K., EDWARDS, C., LAWTON, L.A. and SINGH, B.K. 2016. Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning. Journal of ecology [online], 104(4), pages 936-946. Available from: https://doi.org/10.1111/1365-2745.12585

1. Biodiversity is declining worldwide with detrimental effects on ecosystems. However, we lack a quantitative understanding of the shape of the relationship between microbial biodiversity and ecosystem function (BEF). This limits our understanding o... Read More about Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning..

An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806. (2016)
Thesis
ARIF ABDUL RAHMAN, T. 2016. An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806. Robert Gordon University, PhD thesis.

Cyanobacteria are one of the oldest forms of photosynthetic life and may have contributed significantly to the evolution of oxygen into the then anoxic environment. Cyanobacteria are also one of the best sources of natural secondary metabolites (cyan... Read More about An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806..

A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction. (2016)
Journal Article
FAASSEN, E.J., ANTONIOU, M.G., BEEKMAN-LUKASSEN, W., BLAHOVA, L., CHERNOVA, E., CHRISTOPHORIDIS, C., COMBES, A., EDWARDS, C., FASTNER, J., HARMSEN, J., HISKIA, A., ILAG, L.L., KALOUDIS, T., LOPICIC, S., LURLING, M., MAZUR-MARZEC, H., MERILUOTO, J., POROJAN, C., VINER-MOZZINI, Y. and ZGUNA, N. 2016. A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction. Marine drugs [online], 14(3), article 45. Available from: https://doi.org/10.3390/md14030045

Exposure to β-Ν-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. Analytical chemistry plays a crucial role in determining human BMAA exposure and the associat... Read More about A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction..

Photocatalytic degradation of eleven microcystin variants and nodularin by TiO2 coated glass microspheres. (2015)
Journal Article
PESTANA, C.J., EDWARDS, C., PRABHU, R., ROBERTSON, P.K.J. and LAWTON, L.A. 2015. Photocatalytic degradation of eleven microcystin variants and nodularin by TiO2 coated glass microspheres. Journal of hazardous materials [online], 300, pages 347-353. Available from: https://doi.org/10.1016/j.jhazmat.2015.07.016

Microcystins and nodularin are toxic cyanobacterial secondary metabolites produced by cyanobacteria that pose a threat to human health in drinking water. Conventional water treatment methods often fail to remove these toxins. Advanced oxidation proce... Read More about Photocatalytic degradation of eleven microcystin variants and nodularin by TiO2 coated glass microspheres..

Overcoming the seasonal variations in fitness of the amphipod Corophium Volutator as an environmental toxicology test species using laboratory cultured specimens. (2014)
Thesis
MCGEE, D. 2014. Overcoming the seasonal variations in fitness of the amphipod Corophium Volutator as an environmental toxicology test species using laboratory cultured specimens. Robert Gordon University, MRes thesis.

The marine amphipod Corophium volutator is an important source of food for many fish and wading birds, making it an important species in an estuarine environment and a relevant toxicological test species. Historical data has indicated that seasonal v... Read More about Overcoming the seasonal variations in fitness of the amphipod Corophium Volutator as an environmental toxicology test species using laboratory cultured specimens..

Optimisation of high value metabolite production from benthic marine dinoflagellate Prorocentrum lima. (2014)
Thesis
PRAPTIWI, R.A. 2014. Optimisation of high value metabolite production from benthic marine dinoflagellate Prorocentrum lima. Robert Gordon University, PhD thesis.

Toxins produced by harmful algal blooms (HABs) are known to pose contamination risks to seafood products (e.g. fish and shellfish) consumed by human. In order to control contamination risks, monitoring regimes have to be performed rigorously. The eff... Read More about Optimisation of high value metabolite production from benthic marine dinoflagellate Prorocentrum lima..

A continuous flow packed bed photocatalytic reactor for the destruction of 2-methylisoborneol and geosmin utilising pelletised TiO2. (2013)
Journal Article
PESTANA, C.J., ROBERTSON, P.K.J., EDWARDS, C., WILHELM, W., MCKENZIE, C. and LAWTON, L.A. 2014. A continuous flow packed bed photocatalytic reactor for the destruction of 2-methylisoborneol and geosmin utilising pelletised TiO2. Chemical engineering journal [online], 235, pages 293-298. Available from: https://doi.org/10.1016/j.cej.2013.09.041

Taste and odour compounds, especially geosmin (GSM) and 2-methylisoborneol (2-MIB), cause major problems in both drinking water and aquaculture industries world-wide. Aquaculture in particular has experienced significant financial losses due to the a... Read More about A continuous flow packed bed photocatalytic reactor for the destruction of 2-methylisoborneol and geosmin utilising pelletised TiO2..

Freshwater bacterial diversity, functions and stability. (2013)
Thesis
GIARAMIDA, L. 2013. Freshwater bacterial diversity, functions and stability. Robert Gordon University, PhD thesis.

Biodiversity is declining worldwide with detrimental effects on ecosystems functions and services that it sustains. The relationship between biodiversity and freshwater purification remains unclear. Freshwater purification is of paramount importance... Read More about Freshwater bacterial diversity, functions and stability..

Investigation of the production and isolation of bioactive compounds from cyanobacteria. (2013)
Thesis
HAMEED, S. 2013. Investigation of the production and isolation of bioactive compounds from cyanobacteria. Robert Gordon University, PhD thesis.

Due to heavy nutrient load and adverse climate change the occurrence of toxic cyanobacterial blooms have significantly increased during the last decades. Nodularia spumigena is one of the dominant toxic cyanobacteria which produces massive and inhere... Read More about Investigation of the production and isolation of bioactive compounds from cyanobacteria..

Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water. (2013)
Thesis
CHANDU, V.C.P 2013. Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water. Robert Gordon University, PhD thesis.

The widespread distribution of cyanobacteria and their toxic effects on humans has become a major concern for researchers. Cyanobacteria are a group of oxygenic phototrophic bacteria that exhibit an enormous diversity in shapes and arrangements and o... Read More about Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water..

Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems. (2012)
Thesis
PESTANA, C.J. 2012. Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems. Robert Gordon University, PhD thesis.

Cyanobacterial secondary metabolites can cause serious harm to animals and humans (cyanotoxins) and can have a major financial impact on the potable water and aquaculture industries (taste and odour compounds). Understanding the factors that affect c... Read More about Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems..