Assessment of dapagliflozin effectiveness as add-on therapy for the treatment of type 2 diabetes mellitus in a Qatari population.

Al AdAwi, Rana Moustafa; Jassim, Zainab; Elgaily, Dina; Abdelaziz, Hani; Sree, Bhagya; Mohamed Ibrahim, Mohamed Izham

Abstract

The effectiveness of dapagliflozin in the management of type-2 diabetes mellitus (T2-DM) is an essential issue for establishing a basis for prescribing dapagliflozin. This study aimed to assess the effectiveness of dapagliflozin in combination with other hypoglycemic agents (OHAs) in reducing glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) at 3, 6, 9 and 12 months. This retrospective observational study included all patients who visited the endocrine clinics at Hamad Medical Corporation (HMC) and were treated with dapagliflozin. Demographics and laboratory data were obtained retrospectively from computerized patient medical profiles (eMR-viewer). The main outcome measures were the differences in HbA1c and FBG from baseline at different months. Eighty-one Qatari patients were found to have received dapagliflozin during the study period; 72% of them (n=58) were males, with a mean age of 57.0 ± 9.0 years and a mean baseline HbA1c of 9.0 ± 1.4%. Administration of dapagliflozin as an add-on therapy was found to decrease HbA1c significantly by 0.8 percentage point after 6 months (P=0.006) and by 1.5 percentage point after 12 months (P=0.062). FBG was significantly reduced at 6 months and 9 months (P=0.001 and P=0.03, respectively). Dapagliflozin effectively reduced the HbA1c level and FBG when used in combination with other OHAs or insulin within 6 to 12 months.

Citation

AL ADAWI, R.M., JASSIM, Z., ELGAILY, D., ABDELAZIZ, H., SREE, B. and MOHAMED IBRAHIM, M.I. 2019. Assessment of dapagliflozin effectiveness as add-on therapy for the treatment of type 2 diabetes mellitus in a Qatari population. Scientific reports [online], 9, article 6864. Available from: https://doi.org/10.1038/s41598-019-43052-6

• Journal Article Type: Article
• Acceptance Date: Apr 15, 2019
• Online Publication Date: May 3, 2019
• Publication Date: Dec 31, 2019
• Deposit Date: Jun 11, 2021
• Publicly Available Date: Jun 11, 2021
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Article Number: 6864
• DOI: https://doi.org/10.1038/s41598-019-43052-6
• Keywords: Dapagliflozin; Type 2 diabetes; HbA1c; FBG; Insulin
• Public URL: https://rgu-repository.worktribe.com/output/1352306