Evaluating the effectiveness of pneumococcal vaccines against hospitalization and intensive care unit admission in adults.

El-Bardissy, Ahmed Hossam Eldin; Al‐Adawi, Rana Moustafa; Shible, Ahmed Atef; Albu‐Mahmood , Zainab; Elgaily, Dina Eltayeb; Abdelaziz, Hani

Abstract

Objective: To evaluate the efficacy of pneumococcal vaccines concerning hospital or intensive care unit (ICU) admissions due to pneumonia after vaccination. Setting: Inpatient and ICUs at Hamad General Hospital. Methods: The retrospective study included adults who were vaccinated between June 2012 and June 2013. Patient records were reviewed for hospital or ICU admissions due to pneumonia 2 years before and after vaccination. Main outcomes measures: The primary outcome was to compare the rates of hospital and ICU admissions for pneumonia 2 years before and after vaccination. The secondary outcome was to evaluate the efficacy of pneumococcal vaccines against different comorbidities. Key findings: One hundred sixty-one patients were included with a dominant age group of 64–85 (52%) years old. Comorbidities reported were hypertension (HTN), diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD) and asthma. The rate of hospital admission due to pneumonia was significantly reduced within 2 years after vaccination, 71–39% (P < 0.001). There was a trend towards reduced ICU admission (12.4–10.6%), but the results did not achieve statistical significance (P > 0.72). In diabetic, hypertensive and COPD/Asthma patients, there was a statistically significant reduction in hospitalization. Although there was a reduction in ICU admission for both commodities, the results did not achieve statistical significance. Conclusion: Adults who received pneumococcal vaccines experienced reduced rates of hospital versus ICU admissions due to pneumonia infection.

Citation

EL-BARDISSY, A.H.E., AL-ADAWI, R.M., SHIBLE, A.A., ALBU-MAHMOOD, Z., ELGAILY, D.E. and ABDELAZIZ, H. 2019. Evaluating the effectiveness of pneumococcal vaccines against hospitalization and intensive care unit admission in adults. Journal of pharmaceutical health services research [online], 10(4), pages 427-431. Available from: https://doi.org/10.1111/jphs.12321

• Journal Article Type: Article
• Acceptance Date: Aug 28, 2019
• Online Publication Date: Oct 7, 2019
• Publication Date: Dec 31, 2019
• Deposit Date: Jun 24, 2021
• Publicly Available Date: Jun 24, 2021
• Journal: Journal of Pharmaceutical Health Services Research
• Print ISSN: 1759-8885
• Electronic ISSN: 1759-8893
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 4
• Pages: 427-431
• DOI: https://doi.org/10.1111/jphs.12321
• Keywords: Hospital admission and intensive care admission; Pneumococcal vaccine; Pneumonia
• Public URL: https://rgu-repository.worktribe.com/output/1352315