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The impact of target frequency on intra-individual variability in euthymic bipolar disorder: a comparison of two sustained attention tasks.

Moss, Rachel Ann; Finkelmeyer, Andreas; Robinson, Lucy J.; Thompson, Jill M.; Watson, Stuart; Ferrier, I. Nicol; Gallagher, Peter

Authors

Andreas Finkelmeyer

Lucy J. Robinson

Jill M. Thompson

Stuart Watson

I. Nicol Ferrier

Peter Gallagher



Abstract

Greater intra-individual variability (IIV) in reaction time (RT) on a sustained attention task has been reported in patients with bipolar disorder (BD) compared with healthy controls. However, it is unclear whether IIV is task specific, or whether it represents general crosstask impairment in BD. This study aimed to investigate whether IIV occurs in sustained attention tasks with different parameters. Twenty-two patients with BD (currently euthymic) and 17 controls completed two sustained attention tasks on different occasions: a low target frequency (~20%) Vigil continuous performance test (CPT) and a high target frequency (~70%) CPT version A-X (CPT-AX). Variability measures (individual standard deviation and coefficient of variation) were calculated per participant, and ex-Gaussian modeling was also applied. This was supplemented by Vincentile analysis to characterize RT distributions. Results indicated that participants (patients and controls) were generally slower and more variable when completing the Vigil CPT compared with CPT-AX. Significant group differences were also observed in the Vigil CPT, with euthymic BD patients being more variable than controls. This result suggests that IIV in BD demonstrates some degree of task specificity. Further research should incorporate analysis of additional RT distributional models (drift diffusion and fast Fourier transform) to fully characterize the pattern of IIV in BD, as well as its relationship to cognitive processes.

Citation

MOSS, R.A., FINKELMEYER, A., ROBINSON, L.J., THOMPSON, J.M., WATSON, S., FERRIER, I.N. and GALLAGHER, P. 2016. The impact of target frequency on intra-individual variability in euthymic bipolar disorder: a comparison of two sustained attention tasks. Frontiers in psychiatry [online], 7, article 106. Available from: https://doi.org/10.3389/fpsyt.2016.00106

Journal Article Type Article
Acceptance Date Jun 3, 2016
Online Publication Date Jun 16, 2016
Publication Date Dec 31, 2016
Deposit Date Sep 3, 2021
Publicly Available Date Sep 3, 2021
Journal Frontiers in Psychiatry
Electronic ISSN 1664-0640
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 7
Article Number 106
DOI https://doi.org/10.3389/fpsyt.2016.00106
Keywords Bipolar disorder; Attention; Neuropsychology; Ex-Gaussian distribution; Variability
Public URL https://rgu-repository.worktribe.com/output/1437595

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