Skip to main content

Research Repository

Advanced Search

Pathological response post neoadjuvant therapy for locally advanced rectal cancer is an independent predictor of survival.

On, Jason; Shim, Joanna; Mackay, Craig; Murray, Graeme; Samuel, Leslie; Parnaby, Craig; Ramsay, George

Authors

Jason On

Craig Mackay

Graeme Murray

Leslie Samuel

Craig Parnaby

George Ramsay



Abstract

Aim: Neoadjuvant treatment (NaT) for locally advanced rectal cancer prior to surgery has led to improved outcomes. However, the relationship between pathological response to NaT and survival is not entirely clear. The aim of this study was to assess the degree of pathological response to NaT on survival outcomes. Methods: Clinical and pathological data were collected from a prospectively maintained pathology database between 2005 and 2017. The primary outcome was the overall survival based on pathological response categorized as complete, good partial, partial and minimal. Univariate and multivariate analyses were conducted to identify variables predictive of survival. Cox proportional hazard ratios were used for survival. Results: A total of 596 patients had surgery following NaT for locally advanced rectal cancer. The median follow-up was 4.57 years (interquartile range 2.21–8.15 years). The overall survival for complete pathological response was 75.6% vs. 37.3% for minimal response (P [less than] 0.001). The overall survival at the end of the study in the good partial vs. partial response groups was 58.9% vs. 39% (P [less than] 0.001). On multivariate analysis, the degree of pathological response remains an independent variable for overall and disease-specific survival across all categories. Discussion: In addition to other pathological variables, the degree of pathological response to NaT is an independent predictor for survival outcomes. Future verification of these findings elsewhere could support NaT response being used for adjuvant therapy decision making.

Citation

ON, J., SHIM, J., MACKAY, C., MURRAY, G., SAMUEL, L., PARNABY, C. and RAMSAY, G. 2021. Pathological response post neoadjuvant therapy for locally advanced rectal cancer is an independent predictor of survival. Colorectal disease [online], 23(6), pages 1326-1333. Available from: https://doi.org/10.1111/codi.15512

Journal Article Type Article
Acceptance Date Dec 22, 2020
Online Publication Date Jan 4, 2021
Publication Date Jun 30, 2021
Deposit Date Oct 18, 2021
Publicly Available Date Mar 29, 2024
Journal Colorectal disease
Print ISSN 1462-8910
Electronic ISSN 1463-1318
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 23
Issue 6
Pages 1326-1333
DOI https://doi.org/10.1111/codi.15512
Keywords Rectal cancer; Tumour regression grade; Pathological response
Public URL https://rgu-repository.worktribe.com/output/1447175
Related Public URLs https://rgu-repository.worktribe.com/output/1499943

Files

ON 2021 Pathological response (AAM) (265 Kb)
PDF

Copyright Statement
This is the peer reviewed version of the following article: ON, J., SHIM, J., MACKAY, C., MURRAY, G., SAMUEL, L., PARNABY, C. and RAMSAY, G. 2021. Pathological response post neoadjuvant therapy for locally advanced rectal cancer is an independent predictor of survival. Colorectal disease [online], 23(6), pages 1326-1333, which has been published in final form at https://doi.org/10.1111/codi.15512. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Version [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html#3] .





Related Outputs



You might also like



Downloadable Citations