Adsorption of a diverse range of pharmaceuticals to polyethylene microplastics in wastewater and their desorption in environmental matrices.

McDougall, Louise; Thomson, Lauren; Brand, Sarah; Wagstaff, Antony; Lawton, Linda A.; Petrie, Bruce

Abstract

It is proposed that microplastics discharged from wastewater treatment plants act as a vector of pharmaceuticals. In this study, adsorption of pharmaceuticals to polyethylene microplastics was investigated in municipal wastewater. Pharmaceuticals for study were selected to represent different speciation (anionic, cationic, and neutral) and a range of pH dependant octanol-water distribution coefficients (log DOW). Findings revealed adsorption favoured those in cationic form with the greatest hydrophobicity (e.g., fluoxetine log DOW 2.0 at pH 7.8). Adsorption of anionic pharmaceuticals was restricted due to repulsion with the microplastic's negatively charged surface. Only atorvastatin had any appreciable adsorption due to its comparatively high log DOW value (2.9). Those pharmaceuticals predominantly in neutral form (carbamazepine and ketamine) with log DOW values ≥2.4 had similar adsorption. Freundlich KF values were 3400, 386, 284, 259 and 218 (mg kg−1)(mg L−1)1/n for fluoxetine, propranolol, atorvastatin, ketamine, and carbamazepine, respectively. All pharmaceuticals with log DOW values <1.0 (atenolol, gliclazide, bezafibrate, and ifosfamide) did not adsorb to microplastics, irrespective of their speciation. Changing composition of wastewater (pH, dilution with stormwater and NaCl addition) within the range expected for municipal wastewater had limited influence on adsorption. Pharmaceutical desorption from microplastics was assessed in river water and simulated gastric and intestinal fluids. Solution pH was considered the most important factor for pharmaceutical desorption, influencing both pharmaceutical speciation and microplastic surface charge. Greatest desorption was observed for the cationic pharmaceuticals in gastric fluids due to a reduced surface charge of the microplastics under low pH conditions. Up to 50% desorption of fluoxetine occurred in gastric fluid at 37 °C. These findings show that pharmaceuticals adsorbed to microplastics are ‘bioavailable’. However, this is often overlooked as an exposure route to aquatic organisms because water samples are normally pre-filtered prior to chemical analysis.

Citation

MCDOUGALL, L., THOMSON, L., BRAND, S., WAGSTAFF, A., LAWTON, L.A. and PETRIE, B. 2021. Adsorption of a diverse range of pharmaceuticals to polyethylene microplastics in wastewater and their desorption in environmental matrices. Science of the total environment [online], 808, article 152071. Available from: https://doi.org/10.1016/j.scitotenv.2021.152071

• Journal Article Type: Article
• Acceptance Date: Nov 26, 2021
• Online Publication Date: Dec 2, 2021
• Publication Date: Feb 20, 2022
• Deposit Date: Dec 6, 2021
• Publicly Available Date: Dec 3, 2022
• Journal: Science of the total environment
• Print ISSN: 0048-9697
• Electronic ISSN: 1879-1026
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 808
• Article Number: 152071
• DOI: https://doi.org/10.1016/j.scitotenv.2021.152071
• Keywords: Water pollution; Emerging contaminant; Drug; Sewage; Microplastic; Sorption
• Public URL: https://rgu-repository.worktribe.com/output/1538750
• Additional Information: Supplementary materials have been appended to this accepted manuscript. They consist of one figure and three tables.