Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients.

Gualano, Bruno; Lemes, �talo Ribeiro; Pires da Silva, Rafael; Swinton, Paul

Abstract

This prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n=748). Persistent immunogenicity 6 months after the full-course vaccination was assessed using seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire. Adjusted point estimates from logistic regression models indicated greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]) in physically active patients and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full-course of an inactivated SARS-CoV-2 vaccine.

Citation

GUALANO, B., LEMES, Í.R., PIRES DA SILVA, R. et al. 2022. Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients. Scandinavian journal of medicine and science in sports [online], 32(10), pages 1510-1515. Available from: https://doi.org/10.1111/sms.14213

• Journal Article Type: Article
• Acceptance Date: Jun 30, 2022
• Online Publication Date: Jul 17, 2022
• Publication Date: Oct 31, 2022
• Deposit Date: Jul 5, 2022
• Publicly Available Date: Jul 18, 2023
• Journal: Scandinavian journal of medicine and science in sports
• Print ISSN: 0905-7188
• Electronic ISSN: 1600-0838
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 10
• Pages: 1510-1515
• DOI: https://doi.org/10.1111/sms.14213
• Keywords: Physical activity; Vaccine responses; COVID-19; Immunosuppression; Autoimmune rheumatic disease
• Public URL: https://rgu-repository.worktribe.com/output/1705908