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Hepatic insulin resistance and related obesity: highlighting the ameliorative role of nutraceuticals, dietary intervention, and pharmaceuticals.

Ramadan, Nehal M.; Barbosa, Priscila O.; Abo El-Magd, Nada F.; Eraky, Salma M.; Al-Gayyar, Mohammed M.H.

Authors

Nehal M. Ramadan

Priscila O. Barbosa

Nada F. Abo El-Magd

Salma M. Eraky

Mohammed M.H. Al-Gayyar



Abstract

Insulin resistance (IR) is the unifying denominator of all obesity-related metabolic abnormalities. It possesses a definite higher risk of developing type 2 diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). NAFLD is intimately linked to an accumulation of detrimental oxidative intermediates, which in turn promote insulin receptor substrates serine/threonine phosphorylation and ultimately block hepatic insulin signalling, and hepatic IR. The causal relationship between hepatic IR and NAFLD is bidirectional, and hepatic IR itself is "selective" in terms of resisting only insulin's suppressive effects on glucose production while keeping those enhancing hepatic lipogenesis intact. The present Research Topic aims to highlight the effect of natural compounds, dietary intervention, and synthetic drugs on hepatic IR and disorders related to obesity.

Citation

RAMADAN, N.M., BARBOSA, P.O., ABO EL-MAGD, E.F., ERAKY, S.M. and AL-GAYYAR, M.M.H. 2023. Hepatic insulin resistance and related obesity: highlighting the ameliorative role of nutraceuticals, dietary intervention, and pharmaceuticals. Frontiers in Pharmacology [online], 14, article 1266168. Available from: https://doi.org/10.3389/fphar.2023.1266168

Journal Article Type Editorial
Acceptance Date Jul 28, 2023
Online Publication Date Aug 7, 2023
Publication Date Dec 31, 2023
Deposit Date Sep 1, 2023
Publicly Available Date Sep 1, 2023
Journal Frontiers in pharmacology
Electronic ISSN 1663-9812
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 14
Article Number 1266168
DOI https://doi.org/10.3389/fphar.2023.1266168
Keywords Dietary intervention; Inflammation, drugs; Natural compounds; Hepatic insulin resistance; Obesity
Public URL https://rgu-repository.worktribe.com/output/2052353

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Copyright Statement
© 2023 Ramadan, Barbosa, Abo El-Magd, Eraky and Al-Gayyar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.







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