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Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK women.

Cotton, S.C.; Sharp, L.; Seth, R.; Masson, L.F.; Little, J.; Cruickshank, M.E.; Neal, K.; Waugh, N.


S.C. Cotton

L. Sharp

R. Seth

J. Little

M.E. Cruickshank

K. Neal

N. Waugh


The world age-standardised prevalence of high-risk HPV (hrHPV) infection was 34.2% among 5,038 UK women aged 20–59 years, with a low-grade smear during 1999–2002, assessed for eligibility for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears). High-risk HPV prevalence decreased with increasing age, from 61% at ages 20–24 years to 14–15% in those over 50 years. The age-standardised prevalence was 15.1, 30.7 and 52.7%, respectively, in women with a current normal, borderline nuclear abnormalities (BNA) and mild smear. In overall multivariate analyses, tertiary education, previous pregnancy and childbirth were associated with reduced hrHPV infection risk. Risk of infection was increased in non-white women, women not married/cohabiting, hormonal contraceptives users and current smokers. In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes.


COTTON, S.C., SHARP, L., SETH, R., MASSON, L.F., LITTLE, J., CRUICKSHANK, M.E., NEAL, K. and WAUGH, N. 2007. Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK women. British journal of cancer [online], 97(1), pages 133-139. Available from:

Journal Article Type Article
Acceptance Date May 2, 2007
Online Publication Date May 22, 2007
Publication Date Jul 2, 2007
Deposit Date Sep 4, 2023
Publicly Available Date Sep 22, 2023
Journal British journal of cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 97
Issue 1
Pages 133-139
Keywords Human papillomavirus (HPV); Women patients; Infection
Public URL


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