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Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks.

Nikokavoura, Efsevia A.; Johnston, Kelly L.; Broom, John; Wrieden, Wendy L.; Rolland, Catherine

Authors

Efsevia A. Nikokavoura

Kelly L. Johnston

John Broom

Wendy L. Wrieden

Catherine Rolland



Abstract

Background: Polycystic ovary syndrome (PCOS) affects between 2% and 26% of reproductive-age women in the UK, and accounts for up to 75% of anovulatory infertility. The major symptoms include ovarian disruption, hyperandrogenism, insulin resistance, and polycystic ovaries. Interestingly, at least half of the women with PCOS are obese, with the excess weight playing a pathogenic role in the development and progress of the syndrome. The first-line treatment option for overweight/obese women with PCOS is diet and lifestyle interventions; however, optimal dietary guidelines are missing. Although many different dietary approaches have been investigated, data on the effectiveness of very low-calorie diets on PCOS are very limited. Materials and methods: The aim of this paper was to investigate how overweight/obese women with PCOS responded to LighterLife Total, a commercial very low-calorie diet, in conjunction with group behavioral change sessions when compared to women without PCOS (non-PCOS). Results: PCOS (n=508) and non-PCOS (n=508) participants were matched for age (age ±1 unit) and body mass index (body mass index ±1 unit). A 12-week completers analysis showed that the total weight loss did not differ significantly between PCOS (n=137) and non-PCOS participants (n=137) (-18.5±6.6 kg vs -19.4±5.7 kg, P=0.190). Similarly, the percentage of weight loss achieved by both groups was not significantly different (PCOS 17.1%±5.6% vs non-PCOS 18.2%±4.4%, P=0.08). Conclusion: Overall, LighterLife Total could be an effective weight-loss strategy in overweight/obese women with PCOS. However, further investigations are needed to achieve a thorough way of understanding the physiology of weight loss in PCOS.

Citation

NIKOKAVOURA, E.A., JOHNSTON, K.L., BROOM, J., WRIEDEN.W.L. and ROLLAND, C. 2015. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 8, pages 495-503. Available from: https://doi.org/10.2147/DMSO.S85134

Journal Article Type Article
Acceptance Date May 6, 2015
Online Publication Date Oct 14, 2015
Publication Date Dec 31, 2015
Deposit Date Dec 10, 2015
Publicly Available Date Dec 10, 2015
Journal Diabetes, metabolic syndrome and obesity: targets and therapy
Print ISSN 1178-7007
Electronic ISSN 1178-7007
Publisher Dove Medical Press
Peer Reviewed Peer Reviewed
Volume 8
Pages 495-503
DOI https://doi.org/10.2147/DMSO.S85134
Keywords Obesity; PCOS; LighterLife; VLCD
Public URL http://hdl.handle.net/10059/1365

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