Skip to main content

Research Repository

See what's under the surface

Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks.

Nikokavoura, Efsevia A.; Johnston, Kelly L.; Broom, John; Wrieden, Wendy L.; Rolland, Catherine

Authors

Efsevia A. Nikokavoura

Kelly L. Johnston

John Broom

Wendy L. Wrieden

Catherine Rolland



Abstract

Background: Polycystic ovary syndrome (PCOS) affects between 2% and 26% of reproductive-age women in the UK, and accounts for up to 75% of anovulatory infertility. The major symptoms include ovarian disruption, hyperandrogenism, insulin resistance, and polycystic ovaries. Interestingly, at least half of the women with PCOS are obese, with the excess weight playing a pathogenic role in the development and progress of the syndrome. The first-line treatment option for overweight/obese women with PCOS is diet and lifestyle interventions; however, optimal dietary guidelines are missing. Although many different dietary approaches have been investigated, data on the effectiveness of very low-calorie diets on PCOS are very limited. Materials and methods: The aim of this paper was to investigate how overweight/obese women with PCOS responded to LighterLife Total, a commercial very low-calorie diet, in conjunction with group behavioral change sessions when compared to women without PCOS (non-PCOS). Results: PCOS (n=508) and non-PCOS (n=508) participants were matched for age (age {plusmn}1 unit) and body mass index (body mass index {plusmn}1 unit). A 12-week completers analysis showed that the total weight loss did not differ significantly between PCOS (n=137) and non-PCOS participants (n=137) (-18.5{plusmn}6.6 kg vs -19.4{plusmn}5.7 kg, P=0.190). Similarly, the percentage of weight loss achieved by both groups was not significantly different (PCOS 17.1%{plusmn}5.6% vs non-PCOS 18.2%{plusmn}4.4%, P=0.08). Conclusion: Overall, LighterLife Total could be an effective weight-loss strategy in overweight/obese women with PCOS. However, further investigations are needed to achieve a thorough way of understanding the physiology of weight loss in PCOS.

Journal Article Type Article
Publication Date Dec 31, 2015
Journal Diabetes, metabolic syndrome and obesity: targets and therapy
Print ISSN 1178-7007
Electronic ISSN 1178-7007
Publisher New Publisher Required
Peer Reviewed Peer Reviewed
Volume 8
Pages 495-503
Institution Citation NIKOKAVOURA, E.A., JOHNSTON, K.L., BROOM, J., WRIEDEN.W.L. and ROLLAND, C. 2015. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 8, pages 495-503. Available from: https://doi.org/10.2147/DMSO.S85134
DOI https://doi.org/10.2147/DMSO.S85134
Keywords Obesity; PCOS; LighterLife; VLCD

Files





Downloadable Citations