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β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis.

Saunders, Bryan; Elliott-Sale, Kirsty; Artioli, Guilherme G.; Swinton, Paul A.; Dolan, Eimear; Roschel, Hamilton; Sale, Craig; Gualano, Bruno

Authors

Bryan Saunders

Kirsty Elliott-Sale

Guilherme G. Artioli

Eimear Dolan

Hamilton Roschel

Craig Sale

Bruno Gualano



Abstract

Objective To conduct a systematic review and meta-Analysis of the evidence on the effects of β-Alanine supplementation on exercise capacity and performance. Design This study was designed in accordance with PRISMA guidelines. A 3-level mixed effects model was employed to model effect sizes and account for dependencies within data. Data sources 3 databases (PubMed, Google Scholar, Web of Science) were searched using a number of terms (b € β-Alanine' and b € Beta-Alanine' combined with b € supplementation', b € exercise', b € training', b € athlete', b € performance' and b € carnosine'). Eligibility criteria for selecting studies Inclusion/exclusion criteria limited articles to double-blinded, placebo-controlled studies investigating the effects of β-Alanine supplementation on an exercise measure. All healthy participant populations were considered, while supplementation protocols were restricted to chronic ingestion. Cross-over designs were excluded due to the long washout period for skeletal muscle carnosine following supplementation. A single outcome measure was extracted for each exercise protocol and converted to effect sizes for meta-Analyses. Results 40 individual studies employing 65 different exercise protocols and totalling 70 exercise measures in 1461 participants were included in the analyses. A significant overall effect size of 0.18 (95% CI 0.08 to 0.28) was shown. Meta-regression demonstrated that exercise duration significantly (p=0.004) moderated effect sizes. Subgroup analyses also identified the type of exercise as a significant (p=0.013) moderator of effect sizes within an exercise time frame of 0.5-10b €.min with greater effect sizes for exercise capacity (0.4998 (95% CI 0.246 to 0.753)) versus performance (0.1078 (95% CI b '0.201 to 0.416)). There was no moderating effect of training status (p=0.559), intermittent or continuous exercise (p=0.436) or total amount of β-Alanine ingested (p=0.438). Co-supplementation with sodium bicarbonate resulted in the largest effect size when compared with placebo (0.43 (95% CI 0.22 to 0.64)). Summary/conclusions β-Alanine had a significant overall effect while subgroup analyses revealed a number of modifying factors. These data allow individuals to make informed decisions as to the likelihood of an ergogenic effect with β-Alanine supplementation based on their chosen exercise modality.

Citation

SAUNDERS, B., ELLIOTT-SALE, K., ARTIOLI, G.G., SWINTON, P.A., DOLAN, E., ROSCHEL, H., SALE, C. and GUALANO, B. 2017. ß-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. British journal of sports medicine [online], 51(8), pages 658-669. Available from: https://doi.org/10.1136/bjsports-2016-096396

Journal Article Type Review
Acceptance Date Sep 28, 2016
Online Publication Date Oct 18, 2016
Publication Date Apr 1, 2017
Deposit Date Oct 31, 2016
Publicly Available Date Oct 31, 2016
Journal British journal of sports medicine
Print ISSN 0306-3674
Electronic ISSN 1473-0480
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 51
Issue 8
Pages 658-669
DOI https://doi.org/10.1136/bjsports-2016-096396
Keywords Beta alanine supplementation; Muscle carnosine; Exercise capacity; Exercise performance; Acidosis; Buffering capacity; Sodium bicarbonate; Cosupplementation
Public URL http://hdl.handle.net/10059/1913

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