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Safety of levetiracetam in pregnancy and lactation: a systematic review.

Thomas, Binny; Pallivalapila, Abdulrouf; Al Hail, Moza; Kassem, Wessam El; Al Saad, Doua; Tarannum, Asma; MacLure, Katie; Stewart, Derek C.


Binny Thomas

Abdulrouf Pallivalapila

Moza Al Hail

Wessam El Kassem

Doua Al Saad

Asma Tarannum

Katie MacLure

Derek C. Stewart


Most women with active seizures are often encouraged to continue their antiepileptic medications during pregnancy to avoid serious fetal or maternal complications. Levetiracetam (LEV) is a newer antiepileptic drug used as adjunctive therapy in patients with refractory partial seizures with or without secondary generalization. Because of its broad-spectrum activity, LEV is becoming increasingly used in women with epilepsy of childbearing potential, during pregnancy and thus also during lactation. First generation anti-epileptics are known to cause Major Congenital Malformations (MCM) and developmental problems. However, there is paucity of literature on information regarding safety of Levetiracetam (second generation), use in pregnancy and breastfeeding. The purpose of the present study was to summarize the scientific evidence behind use of LEV during pregnancy and lactation.


THOMAS, B., ROUF, A., AL HAIL, M.S., ELKASSEM, W.M., ALSAAD, D., TARANNUM, A., MACLURE, K. and STEWART, D. 2016. Safety of levetiracetam in pregnancy and lactation: a systematic review. Presented at the 9th Medication safety conference, 4-6 November 2016, Abu Dhabi, UAE.

Presentation Conference Type Poster
Conference Name 9th Medication safety conference
Conference Location Abu Dhabi, UAE
Start Date Nov 4, 2016
End Date Nov 6, 2016
Deposit Date May 19, 2017
Publicly Available Date May 19, 2017
Keywords Seizures; Pregnancy; Antiepileptic drugs; Levetiracetam; Breastfeeding; Safety; Epilepsy
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