Skip to main content

Research Repository

Advanced Search

Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a laboratory study.

Dang, Lei; Wardlaw, Douglas; Hukins, David W.L.

Authors

Lei Dang

Douglas Wardlaw

David W.L. Hukins



Abstract

A laboratory study was conducted on cadaveric sheep spines to develop an effective procedure for removing as much nucleus as possible from an intervertebral disc with minimal disruption to the annulus. The results of many studies involving removal of nucleus using chymopapain (including chemonucleolysis) have been published, but we are not aware of any previous quantitative studies on procedures for removing as much nucleus as possible from the disc. All procedures were performed via a 3 mm trocar. Four procedures were compared: (I) unilateral approach using rongeurs alone, (II) bilateral approach using rongeurs alone, (III) unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. The percentages of nucleus removed were: (I) 34%, (II) 41%, (III) 52% and (IV) 75%; there were significant differences between the four sets of results according to ANOVA. This therefore shows that significantly more nucleus is removed using a bilateral than a unilateral approach; significantly more nucleus is removed if chymopapain is used in addition to rongeurs. A brush is useful in removing strands of nucleus loosened by chymopapain.

Citation

DANG, L., WARDLAW, D. and HUKINS, D.W.L. 2007. Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a laboratory study. BMC musculoskeletal disorders [online], 8, article 122. Available from: https://doi.org/10.1186/1471-2474-8-122

Journal Article Type Article
Acceptance Date Dec 13, 2007
Online Publication Date Dec 13, 2007
Publication Date Dec 31, 2007
Deposit Date Aug 8, 2017
Publicly Available Date Aug 8, 2017
Journal BMC musculoskeletal disorders
Electronic ISSN 1471-2474
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 8
Article Number 122
DOI https://doi.org/10.1186/1471-2474-8-122
Keywords Laboratory study; Cadaveric sheep spines; Nucleus; Inververtebral disc
Public URL http://hdl.handle.net/10059/2427

Files





Downloadable Citations